研究领域
有氧呼吸过程中产生的活性氧，在病理条件下所致的氧化还原调控失衡，以及病理条件下过量产生的一氧化氮及其代谢过程中形成其他形式的活性氮，是导致衰老、神经退行性疾病、糖尿病和炎症炎等的重要因素。在活性氧和活性氮的产生及其所致的机体损伤中，微量元素铁起了重要的介导作用。本课题组基础研究以活性氧和活性氮的生物化学为中心，涉及过渡金属离子催化活性氧和活性氮的产生及蛋白质损伤，及其以活性氧和活性氮的抑制为主的天然药物药理学评价，
此外，课题组还进行一些应用研究，目前在硅酸盐湿法分解技术开发方面已经与合作单位获得两项专利授权，并正在进行产业化开发。
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Yi Huang, Youxia Shuai, Hailing Li, Zhonghong Gao!*. Tyrosine residues play an important role in heme detoxification by serum albumin. Biochimica et Biophysica Acta-General Subjects. 2014, 1840(3):970-6
Can Yuan, Zhonghong Gao!*. Abinteracts with both the iron center and the porphyrin ring of heme: mechanism of heme’s action on Abaggregation and disaggregation. Chemical Research in Toxicology. 2013, 26(2):262-9.
Min Tu, Hayder A. Abbood, Zhening Zhu, Hailing Li, Zhonghong Gao!*. Investigation of the photocatalytic effect of zinc oxide nanoparticles in the presence of nitrite. Journal of Hazardous Materials. 2013, 244-245: 311-321.
Min Tu, Yi Huang, Hailing Li, Zhonghong Gao!*. The stress caused by nitrite with titanium dioxide nanoparticles under UVA irradiation in human keratinocyte cell. Toxicology. 2012, 299: 60-68.
Can Yuan, Lian Yi, Zhen Yang, Qingqing Deng, Yi Huang, Hailing Li, Zhonghong Gao!*. Amyloid-beta-heme peroxidase promoted protein nitrotyrosination: relevance to widespread protein nitration in Alzheimer’s disease. Journal of Biological Inorganic Chemistry. 2012, 17(2):197-207.
Naihao Lu, Yan Zhang, Hailing Li, Zhonghong Gao !*. Oxidative and nitrative modifications of alpha-enolase in cardiac proteins from diabetic rats. Free Radical Biology & Medicine. 2010 48(7):873-881
Yan Zhang, Naihao Lu, Zhonghong Gao!*. Hemin-H2O2-NO2- induced protein oxidation and tyrosine nitration is different from that of SIN-1: A study on glutamate dehydrogenase nitrative/oxidative modification. International Journal of Biochemistry and Cell Biology. 2009, 41(4):907-15.
Naihao Lu, Zhening Zhu, Xuqi Zhao, Ran Tao, Xiangliang Yang, Zhonghong Gao!*. Nano titanium dioxide photocatalytic protein tyrosine nitration:A potential hazard of TiO2 on skin. Biochemical and Biophysical Research Communications. 2008, 370(4):675-80.
Naihao Lu, Mingyi Zhang, Hailing Li, ZhonghongGao!*, Completely different effects of desferrioxamine on hemin/nitrite/H2O2-induced bovine serum albumin nitration and oxidation. Chemical Research in Toxicology. 2008, 21(6), 1229–1234.
Yuling Zhao, Hailing Li,Zhonghong Gao!*, Huibi Xu. Effects of dietary baicalin supplementation on iron overload induced mouse liver oxidative injury. European Journal of Pharmacology. 2005, 509(2-3): 195-200
Ka Bian*, Zhonghong Gao*Norman Weisbrodt and Ferid Murad. The nature of Hemin/iron–induced protein tyrosine nitration. Proceedings of the National Academy of Sciences USA. 2003, 100(10):5712-7 (* Equally contributed to this paper)
Zhonghong Gao, Kaixun Huang, Huibi Xu. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacological Research. 2001, 43:173-178 (cited: 134)
Zhonghong Gao, Kaixun Huang, Xiangliang Yang, Huibi Xu. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochimica et Biophysica Acta, 1999, 1472(3): 643-650.(cited: 316)
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