个人简介
张晓书,女,博士,副教授,2014年毕业于沈阳药科大学,获博士学位,2015年留校任教,主要研究方向为功能食品的物质基础及作用机制研究等。作为课题负责人主持国家自然科学基金青年基金1项,辽宁省教育科技向目1项,沈阳药科大学中青年教师事业发展支持计划1项,辽宁省大学生创新训练项目1项。另外,作为主要完成人参与国家“十一五”重大专项1项,国家“十一五”重大专项子平台项目1项,其他省、市级科研项目4项。目前已在JournalofFunctionalFood,Phytochemistry,JournalofAgriculturalandFoodChemistry等期刊发表论文20余篇。
研究领域
研究方向一:保健食品及功能性食品的物质基础研究
研究方向二:具有抗乳腺癌的天然功能因子的发现与制备
研究方向三:抗乳腺癌活性成分的发现及作用机制研究
近期论文
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1.JiayinYue,YuanyuanSun,JingXu,JiaqingCao,GangChen,HuixingZhang,XiaoshuZhang*,YuqingZhao*.CucurbitanetriterpenoidsfromthefruitofMomordicacharantiaL.andtheiranti-hepaticfibrosisandanti-hepatomaactivities.Phytochemistry.157(2019)21–27.(IF3.2)
2.YumengZhang,WeihuiYuan,XudeWang,HongyuZhang,YuanyuanSun,XiaoshuZhang*andYuqingZhao*.Synthesis,characterizationandcytotoxicactivityevaluationofginsengdioloxidationandnitrogenhybridderivatives.MedChemComm.DOI:10.1039/c8md00387d.IF2.342
3.JingXu,XudeWang,GuangyueSu,YuanyuanSun,JiaqingCao,XiaoshuZhang*,YuqingZhao*.Theantioxidantandanti-hepaticfibrosisactivitiesofacorns(Quercusliaotungensis)andtheirnaturalgalloyltriterpenes.JournalofFunctionalFoods46(2018)567–578.(IF3.47)
4.XiaoshuZhang,GuohuiShi,MingbingLiu,RongChen,XiaojunWu,YuqingZhao*.Fournewdammarane-typetriterpenesderivativesfromhydrolyzateoftotalGynostemmapentaphyllumsaponinsandtheirbioactivities.NaturalProductResearch.2018.1-7.(IF1.8)
5.JingXu,JiaqingCao,JiayinYue,XiaoshuZhang*,YuqingZhao*.NewtriterpenoidsfromacornsofQuercusliaotungensisandtheirinhibitoryactivityagainstα-glucosidase,α-amylaseandprotein-tyrosinephosphatase.JournalofFunctionalFoods.2018,41:232-239.(IF3.47)
6.JingXu,JiaqingCao,JiayinYue,XiaoshuZhang*,YuqingZhao*.NewtriterpenoidsfromacornsofQuercusliaotungensisandtheirinhibitoryactivityagainstα-glucosidase,α-amylaseandprotein-tyrosinephosphatase.JournalofFunctionalFoods.2018,41:232-239.(IF3.47)
7.XiaoshuZhang,GuohuiShi,MingbingLiu,RongChen,XiaojunWu,YuqingZhao*.Fournewdammarane-typetriterpenesderivativesfromhydrolyzateoftotalGynostemmapentaphyllumsaponinsandtheirbioactivities.NaturalProductResearch.2018.1-7.(IF1.92)
8.XiaoshuZhang,GuohuiShi,MingbingLiu,RongChen,XiaojunWu,YuqingZhao*.Protectiveeffectsofdammarane-typetriterpenesfromhydrolyzateofGynostemmapentaphyllumagainstH2O2-inducedinjuryandanti-hepaticfibrosisactivities.PhytochemistryLetters.25(2018)33–36.(IF1.5)
9.LuMa,YuancaiChen,XudeWang,MingzhouXiong,YuanyuanSun,XiaoshuZhang*,YuqingZhao*.Design,characterization,andinvitroantiproliferativeefficacyofgemcitabineconjugatesbasedoncarboxymethylglucan.Bioorganic&MedicinalChemistryLetters.28(2018)2920–2924.(IF2.442)
10.JingXu,XudeWang,JiayinYue,YuanyuanSun,XiaoshuZhangandYuqingZhao*.PolyphenolsfromAcornLeaves(Quercusliaotungensis)ProtectPancreaticBetaCellsandTheirInhibitoryActivityagainsta-GlucosidaseandProteinTyrosinePhosphatase1B.Molecules.2018,23:2167.(IF3.2)