个人简介
黄肖霄,副教授。2014年毕业于沈阳药科大学天然药物化学专业,获得博士学位,毕业后留校任教,2016年12月被聘为副教授、硕士生导师。2015年11月进入中国人民解放军第二一〇医院开展博士后研究工作。目前主要承担本科天然药物化学、有机化合物波谱解析、药用活性成分的体外筛选等课程。科研主要方向为药用植物中活性先导化合物的快速发现,侧重于发现天然产物中的光学混合物并进行手性拆分,利用计算化学确定其立体构型,以光学纯的化合物为基础进行生物学研究,基于作用的靶点研究对映体活性差异性的原因。
本人近年后主持国家自然科学基金面上项目1项、国家自然基金青年项目1项、博士后科学基金特别资助1项、博士后科学基金面上项目1项、以及省市级项目多项,并作为骨干成员参与了国家自然基金6项。近年在JournalofNaturalProducts、Phytochemistry、JounalofAgriculturalandFoodChemistry、EuropeanJournalofMedicinalChemistry等杂志上发表第一/通讯作者SCI论文72篇(对于天然产物中对映异构体的研究已经发表系列SCI论文27篇)。
研究领域
研究方向一:药用植物中活性先导化合物的快速发现
研究方向二:天然来源光学混合物的手性拆分及手性中心对于生物活性的影响
近期论文
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1.QiangRen,Wen-YuZhao,Shao-ChunShi,Feng-YingHan,Ying-YingZhang,Qing-BoLiu,Guo-DongYao,BinLin,Xiao-XiaoHuang*,Shao-JiangSong*.Guaiane-typesesquiterpenoidsfromtherootsofDaphnegenkwaandevaluationoftheirneuroprotectiveeffects.JournalofNaturalProducts.2019,82,1510−1517.(通讯作者;影响因子IF:4.257)
2.Wen-YuZhao,Xiao-YuSong,LuZhao,Chun-XinZou,Wei-YuZhou,BinLin,Guo-DongYao,Xiao-XiaoHuang*,Shao-JiangSong*.QuassinoidsfromPicrasmaquassioidesandtheirneuroprotectiveeffects.JournalofNaturalProducts.2019,82,714−723.(通讯作者;影响因子IF:4.257)
3.Xiao-LiQi,Ying-YingZhang,PengZhao,LeZhou,Xiao-BoWang,Xiao-XiaoHuang*,BinLin*,Shao-JiangSong*.ent-KauranediterpenoidswithneuroprotectivepropertiesfromCornSilk(Zeamays).JournalofNaturalProducts,2018,81:1225-1234.(通讯作者;影响因子IF:4.257)
4.LeZhou,Guo-DongYao,Xiao-YuSong,JieWang,BinLin,Xiao-BoWang,Xiao-XiaoHuang*,andShao-JiangSong*.Neuroprotectiveeffectsof1,2-diarylpropanetypephenylpropanoidenantiomersfromredraspberryagainstH2O2-inducedoxidativestressinhumanneuroblastomaSH-SY5Ycells.JounalofAgriculturalandFoodChemistry.2018,66,331−338.(通讯作者;影响因子IF:3.571一区)
5.LeZhou,Guo-DongYao,Li-WeiLu,Xiao-YuSong,BinLin,Xiao-BoWang,Xiao-XiaoHuang*,Shao-JiangSong*.NeolignansfromRedRaspberry(RubusidaeusL.)exhibitenantioselectiveneuroprotectiveeffectsagainstH2O2‑inducedoxidativeinjuryinSH-SY5YCells.JounalofAgriculturalandFoodChemistry.2018,66,11390−11397.(通讯作者;影响因子IF:3.571;一区)
6.QianSun,Guo-DongYao,Xiao-YuSong,Xiao-LiQi,Yu-FeiXi,Ling-ZhiLi,Xiao-XiaoHuang*,Shao-JiangSong*.AutophagyantagonizesapoptosisinducedbyflavanenantiomersfromDaphnegiraldiiinhepaticcarcinomacellsinvitro.EuropeanJournalofMedicinalChemistry.133:1−10,2017.(通讯作者;影响因子IF:4.816)
7.MingBai,Guo-DongYao,QiangRen,QinLi,Qing-BoLiu,YanZhang,Xiao-BoWang,Xiao-XiaoHuang*,Shao-JiangSong*.Triterpenoidsaponinsandflavonoidsfromlicoriceresidueswithanti-inflammatoryactivity.IndustrialCrops&Products,2018,125:50–58.(通讯作者;影响因子IF:4.191;一区)
8.Xiao-LiQi,PengZhao,Ying-YingZhang,MingBai,BinLin,Xiao-XiaoHuang*,Shao-JiangSong*.Sesquiterpenesfromstigmamaydis(Zeamays)asacropby-productandtheirpotentialneuroprotectionandinhibitoryactivitiesofAβaggregation.IndustrialCrops&Products,2018,111:590–596.(通讯作者;影响因子IF:4.191;一区)
9.LeZhou,JieWang,RuiGuo,BinLin,Xiao-BoWang,Xiao-XiaoHuang*,Shao-JiangSong*.DiscoveryofdihydrobenzofuranneolignansfromRubusideausL.withenantioselectiveanti-Aβ1-42aggregationactivity.BioorganicChemistry.2018,80:64-69.(通讯作者;影响因子IF:3.926)
10.Si-FanLiu,BinLin,Yu-FeiXi,LeZhou,Li-LiLou,Xiao-XiaoHuang,*Xiao-BoWang*,Shao-JiangSong*.BioactivespiropyrrolizidineoxindolealkaloidenantiomersfromIsatisindigoticaFortune.Organic&BiomolecularChemistry.2018,16,9430–9439.(通讯作者;影响因子IF:3.423)