高栓虎 - 华东师范大学 - 化学与分子工程学院

个人简介

工作经历 2010.10－至今：华东师范大学，化学与分子工程学院 / 上海市绿色化学与化工过程绿色化重点实验室 / 上海分子治疗与新药创制工程技术研究中心教授，博士生导师教育经历 1997.9－2001.7：兰州大学化学化工学院，学士 2001.9－2006.7：兰州大学，功能有机分子国家重点实验室，博士，导师：涂永强院士 2006.7－2010.9：美国西南医学中心，博士后，导师： Chuo Chen 教授荣誉及奖励药明康德生命化学研究奖−学者奖（2021）上海市优秀学术带头人（2018） ACP-Lecture Awards (to Hong Kong and Japan)（2016）中国化学会青年化学奖（2014） Thieme Chemistry Journal Award （2014）

研究领域

活性天然产物全合成研究导向天然产物的合成方法学研究天然产物药物化学研究

近期论文

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Hao Shao, Wenheng Liu, Muhan Liu, Haibing He, Qi-Lin Zhou, Shou-Fei Zhu*, Shuanhu Gao* Asymmetric Synthesis of cyclopamine, a Hedgehog (Hh) Signaling Pathway Inhibitor J. Am. Chem. Soc.2023, 145, 25086–25092. DOI: 10.1021/jacs.3c10362 Hui Wang, Yi Liu, Hongyuan Zhang, Baochao Yang, Haibing He, and Shuanhu Gao * Asymmetric Total Synthesis of Cephalotaxus Diterpenoids: Cephinoid P, Cephafortoid A, 14-epi-Cephafortoid A and Fortalpinoids M?N, P J. Am. Chem. Soc. 2023, 145, 16988–16994. DOI: 10.1021/jacs.3c05455 Shaolei Ding, Yingbo Shi, Baochao Yang, Min Hou, Haibing He, and Shuanhu Gao* Asymmetric Total Synthesis of Hasubanan Alkaloids: Periglaucines A–C, N,O-dimethyloxostephine and Oxostephabenine Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202214873. Yanyu Chen, Zhengyuan Xin, Hui Wang, Haibing He and Shuanhu Gao* Asymmetric total synthesis of norzoanthamine and formal synthesis of zoanthenol Org. Chem. Front. 2023, 10, 651–660. Quan Zhang, Haibing He and Shuanhu Gao* Total synthesis of streptovertidione and bioinspired transformation to streptovertidine A and formicapyridine A Chem. Commun., 2022, 58, 4239–4242. (This article is part of the themed collection: 2022 Pioneering Investigators) Baochao Yang, Guoen Wen, Quan Zhang, Min Hou, Haibing He, Shuanhu Gao* Asymmetric Total Synthesis and Biosynthetic Implications of Per-ovskones, Hydrangenone and Hydrangenone B J. Am. Chem. Soc. 2021, 143, 6370?6375. Zhengyuan Xin, Hui Wang, Haibing He, Xiaoli Zhao, Shuanhu Gao* Asymmetric Total Synthesis of Norzoanthamine Angew. Chem. Int. Ed. 2021, 60, 12807?12812. Mengmeng Xu,? Min Hou,? Haibing He, Shuanhu Gao* Asymmetric Total Synthesis of Aglacins A, B and E Angew. Chem. Int. Ed. 2021, 60, 16655–16660. Kuanwei Chen, Tao Xie, Yanfang Shen, Haibing He, Xiaoli Zhao*, Shuanhu Gao* Calixanthomycin A: Asymmetric Total Synthesis and Structural Determination Org. Lett. 2021, 23, 1769?1774. Chaoying Zheng, Tao Xie, Haibing He,* Shuanhu Gao* Asymmetric Total Synthesis of PD-116740 Org. Lett. 2021, 23, 469?473. Min Hou, ? Mengmeng Xu, ? Baochao Yang, Haibing He, Shuanhu Gao* Construction of Polycyclic Structures with Vicinal Quaternary Stereocenters via Enantioselective Photoenolization/Diels–Alder Reaction Chem. Sci. 2021, 12, 7575–7582. Xiao-Long Lu,? Yuanyou Qiu,? Baochao Yang, Haibing He, and Shuanhu Gao* Asymmetric Total Synthesis of (+)-Xestoquinone and (+)-Adociaquinones A and B Chem. Sci. 2021, 12, 4747–4752. Hongyuan Zhang, Haibing He, Shuanhu Gao,* Asymmetric Total Synthesis of Cephanolide A Angew. Chem. Int. Ed. 2020, 59, 20417–20422. Delu Jiang, Kunyun Xin, Baochao Yang, Yanyu Chen, Quan Zhang, Haibing He, Shuanhu Gao* Total Synthesis of Three Families of Natural Antibiotics: Anthrabenzoxocinones Fasamycins/naphthacemycins and Benastatins CCS Chemistry, 2020, 2, 800-812. Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma,* Shuanhu Gao,* Xiangbing Qi* An Alkaloid Initiates Phosphodiesterase 3A–Schlafen 12 Dependent Apoptosis without Affecting the Phosphodiesterase Activity, Nature Communications, 2020, 11,3236. Yonglei Que, Hao Shao, Haibing He, Shuanhu Gao* Total Synthesis of Farnesin via an Excited-State Nazarov Reaction Angew. Chem. Int. Ed. 2020, 59, 7444-7449. Highlighted by Synfacts. 2020, 16, 498. Tao Xie, Chaoying Zheng, Kuanwei Chen, Haibing He, Shuanhu Gao* Asymmetric Total Synthesis of the Complex Polycyclic Xanthone FD‐594 Angew. Chem. Int. Ed. 2020, 59, 4360-4364. Highlighted by Synfacts. 2020, 16, 374. Yang Ji, Zhengyuan Xin, Haibing He, Shuanhu Gao* Total Synthesis of Viridin and Viridiol J. Am. Chem. Soc. 2019, 141, 16208-16212. Highlighted by Synfacts. 2020, 16, 119. Jiaxin Zhong, Haibing He,* Shuanhu Gao* Exploration of 1, 3-dipolar Cycloaddition Reaction to Construct the Core Skeleton of Calyciphylline A-type Alkaloids Org. Chem. Front., 2019, 6, 3781-3785. Jiaxin Zhong, Kuanwei Chen, Yuanyou Qiu, Haibing He, and Shuanhu Gao* A Unified Strategy To Construct the Tetracyclic Ring of Calyciphylline A Alkaloids: Total Synthesis of Himalensine A Org. Lett. 2019, 21, 3741-3745. Dongsheng Xue, Mengmeng Xu, Chaoying Zheng, Baochao Yang, Min Hou, Haibing He, Shuanhu Gao* Titanium-promoted Intramolecular Photoenolization/Diels–Alder Reaction to Construct Polycyclic Terpenoids: Formal Synthesis of Mycoleptodiscin A Chin. J. Chem. 2019, 37, 135-139. Baochao Yang, Shuanhu Gao* Recent Advances in the Application of Diels-Alder Reactions Involving O-quinodimethanes O-quinone Methides and Aza-o-quinone Methides in Natural Products Total Synthesis Chem. Soc. Rev., 2018, 47, 7926-7953. Yihua Dai, Feixia Ma, Yanfang Shen, Tao Xie, Shuanhu Gao* Convergent Synthesis of Kibdelone C Org. Lett.2018, 20, 2872–2875. Highlighted by Synfacts. 2018, 14, 784. Yuanyou Qiu, Jiaxing Zhong, Shan Du, Shuanhu Gao* Synthetic Studies on Daphniglaucins Chem. Commun., 2018, 54, 5554-5557. Yingbo Shi, Yang Ji, Kunyun Xin and Shuanhu Gao* Total synthesis of (?)-Xestosaprol N and O Org. Lett. 2018, 20, 732–735. Yingbo Shi, Haibing He, Shuanhu Gao* Recent Advances in the Total Synthesis of Gracilamine Chem. Commun., 2018, 54, 12905-12913. Graphical abstract:Recent advances in the total synthesis of gracilamine Yihua Dai, Yanfang Shen, Shuanhu Gao* Cascade Halo-Michael/Aldol Reaction and Its Application in Synthesis Chin. J. Org. Chem. 2018, 38, 1608-1625. Baochao Yang, Shuanhu Gao* The Application of Photochemical Rearrangement of Santonin in Total Synthesis of Complex Natural Terpenoids Acta Chim. Sinica. 2018, 76, 161-167. Yingbo Shi, Qiaoling Wang, Shuanhu Gao* Recent Advances of Using Intramolecular Mannich-reaction in Total synthesis of Alkaloids Org. Chem. Front. 2018, 5, 1049 – 1066. Xiaojun Li, Wanbin Zhang,* Shuanhu Gao* Total Synthesis of Complex Natural Products: Combination of Chemical Synthesis and Biosynthesis Strategies Chin. J. Org. Chem. 2018, 38, 2185-2198. Baochao Yang, Kuaikuai Lin, Yingbo Shi, Shuanhu Gao* Ti(Oi-Pr)4-promoted photoenolization Diels–Alder reaction to construct polycyclic rings and its synthetic applications Nature Communications, 2017, 8, 622. Xiaojun Li, Qingfei Zheng, Jun Yin, Wen Liu* and Shuanhu Gao* Chemo-enzymatic Synthesis of Equisetin Chem. Commun., 2017, 53, 4695 – 4697. Zheming Xiao, Yayue Li, and Shuanhu Gao* Total Synthesis and Structural Determination of the Dimeric Tetrahydroxanthone Ascherxanthone A Org. Lett. 2017, 19, 1834–1837. Dan Wang, Min Hou, Yue Ji, and Shuanhu Gao* Total Synthesis of Scholarisine K and Alstolactine A Org. Lett., 2017, 19, 1922-1925. Ke Li, Jinjie Ou, Shuanhu Gao* Total Synthesis of Camptothecin and Related Natural Products by a Flexible Strategy Angew. Chem. Int. Ed. 2016, 55, 14778–14783. Xiaojun Li, Dongsheng Xue, Cheng Wang, Shuanhu Gao* Total Synthesis of Hamigerans Angew. Chem. Int. Ed. 2016, 55, 9942–9946. Yuanyou Qiu and Shuanhu Gao* Trends in Applying C–H Oxidation to Total Synthesis of Natural Products Nat. Prod. Rep., 2016, 33, 562-581. Shuanhu Gao*, Yuanyou Qiu Advances of Radical and Photo Reactions in Natural Products Synthesis Sci. Chin. Chem. 2016, 59, 1093-1108. Yingbo Shi and Shuanhu Gao* Recent Advances of Synthesis of Fluorenone and Fluorene Containing Natural Products Tetrahedron, 2016, 72, 1717-1735. Shuanhu Gao,* Advances of Radical and Photo Reactions in Natural Products Synthesis A Photo-induced C-C Bond Formation Methodology to Construct Tetrahydrofluorenones and Related Structures Org. Chem. Front. 2016, 3, 354-358. Yingbo Shi, Baochao Yang, Shujun Cai, and Shuanhu Gao* Total Synthesis of Gracilamine Angew. Chem. Int. Ed. 2014, 53, 9539-9543. Highlighted by Synfacts, 2014, 10, 1011. Lili Kong, Mingjin Rao, Jinjie Ou, Jun Yin, Weiqiang Lu, Mingyao Liu, Xiufeng Pang,* and Shuanhu Gao* Total Synthesis and Biological Studies of Cryptocin and Derivatives of Equisetin and Fusarisetin A Org. Biomol. Chem., 2014, 12, 7591-7597. Shujun Cai, Zheming Xiao, Yingbo Shi and Shuanhu Gao* The Photo-Nazarov Reaction: Scope and Applications Chem.-Eur. J. 2014, 20, 8677-8681. Dan Wang, Shuanhu Gao* Sonogashira Coupling in Natural Product Synthesis Org. Chem. Front. 2014, 1, 556-566. Zheming Xiao, Shujun Cai, Yingbo Shi, Baochao Yang, Shuanhu Gao* Photo-induced C-O Bond Formation to Construct Tetrahydroxanthones Chem. Commun. 2014, 50, 5254-5257. (Invited for “2014 Emerging Investigators Issue”) Jun, Yin; Gao Shuanhu* Total Synthesis of (+)-Fusarisetin A: A Biomimetic Approach Synlett. 2014, 25, 1-7. (Invited Synpacts) Ke Li, Cheng Wang, Baochao Yang, Shuanhu Gao* Construction of the Basic Skeleton of Ophiobolin A and Variecolin Org. Biomol. Chem., 2013, 11, 7550-7558. Cheng Wang, Dan Wang, and Shuanhu Gao* Total Synthesis of Cyanthiwigins A, C, G and H Org. Lett. 2013, 15, 4402-4405. Jun Yin, Lili Kong, Cheng Wang, YingboShi, Shujun Cai, and Shuanhu Gao* Biomimetic Synthesis of Equisetin and (+)-Fusarisetin A Chem.-Eur. J. 2013, 39, 13040-13046. Highlighted in ChemistryViews Jun, Yin; Kong, Lili; Gao Shuanhu* Synthetic Progress of FusarisetinA Chin. J. Org. Chem.2013, 33, 259-266. Jun Yin? Cheng Wang? LiliKong? Shujun Cai? Shuanhu Gao* AsymmetricSynthesisand Biosynthetic Implications of (+)-Fusarisetin A Angew. Chem. Int. Ed. 2012? 51, 7786-7789. Highlighted in Chemical & Engineering News (JUNE 25, 2012) Highlighted in Organic Chemsitry Portal Highlighted in Chin. J. Org. Chem. Publications during Ph. D. and Postdoctor's research Shi, H.; De, S.; Wang, Q.; Shuanhu Gao; Wang, X.; Chuo Chen Construction of the 5,6,7-tricyclic skeleton of lancifodilactone F Tetrahedron Lett. 2015, 56, 3225. Zhiqiang Ma?, Xiaolei Wang?, Xiao Wang, Rodrigo A. Rodriguez, Shuanhu Gao, Xianghui Tan, Yuyong Ma, Curtis E. Moore, Arnold L. Rheingold, Phil S. Baran and Chuo Chen Asymmetric syntheses, structural refinement, and biosynthetic implications of sceptrin, massadine, and ageliferin Science, 2014, 346, 219-224. Gao Shuanhu; Chen Chuo Total Synthesis of Natural Products–At the Frontiers of Organic Chemistry; Nakiterpiosin (Chapter 2). Li, J. J., Corey, E. J., Eds.; Springer-Verlag: Berlin/Heidelberg, 2013; 25–38. Gao, Shuanhu; Wang, Qiaoling; Wang, Gelin; Lomenick, Brett; Liu, Jie; Fan, Chih-Wei; Deng, Lih-Wen; Huang, Jing; Lum, Lawrence; Chen, Chuo The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids Synlett,2012,23, 2298. Shuanhu Gao; Qiaoling Wang; Lawrence Lum; Chuo Chen*. Chemical and Biological Studies of Nakiterpiosin andNakiterpiosinone J. Am. Chem. Soc. 2010?132? 371. Shuanhu Gao; Qiaoling Wang; Chuo Chen*. Synthesis andStructure Revision of Nakiterpiosin J. Am. Chem. Soc. 2009? 131? 1410. J. R.Falck;* Shuanhu Gao; Ravi Naga Prasad; SreenivasuluReddy Koduru. Electrophilic α-thiocyanation of chiral andachiralN-acyl imides. A convenient route to 5-substituted and 5?5-disubstituted 2?4-thiazolidinediones Bioorg. Med. Chem. Lett. 2008? 18? 1768. Shuanhu Gao;Yong-Qiang Tu*; Xiangdong Hu; Rongbao Hua; Yijun Jiang; Yuming Zhao; Xiaohui Fan; Shuyu Zhang. General and Efficient Strategy for Erythrinan and Homoerythrinan Alkaloids: Syntheses of (±)-3-demethoxyerythratidinone and (±)-Erysotramidine Org. Lett. 2006? 8?2373. Shuanhu Gao;Yong-QiangTu*; Zhenlei Song; Aixia Wang; Xiaohui Fan; Yijun Jiang. A General and Efficient Strategy for 7-Aryloctahydroindoleandcis-3a-Aryloctahydroindole Alkaloids: Total Syntheses of (±)-γ-Lycorane and(±)-Crinane J. Org. Chem. 2005? 70?6523. Shuanhu Gao; Yanxing, Jia; Xuezhi Zhao; Yongqiang Tu* A Novel Strategy for the Key Fully Substituted Cyclopentenedione Moiety of Madindonlines via AlEt3-promoted TandemReductive Rearrangement of Hydroxy Epoxides Chin. J. Chem. 2006, 24, 595. Xiang-Dong Hu; Yong-Qiang Tu*; En Zhang; Shuanhu Gao; Shaohua Wang; Aixia Wang; Chun-An Fan; Min Wang. TotalSynthesis of (±)-Galanthamine Org. Lett. 2006?8?1823. Ai-Xia Wang; ZhenLei, Song; Shuanhu Gao; Yi-Jun Jiang; Dao-Yi Yuan; Yong-Qiang Tu; Ning-Zi Li. Studies on Wagner-Meerwein rearrangement of benzospirocyclic β-bromoketones and application to formal synthesis of (±)-Colchicine Youji Huaxue 2007, 27, 1171. Ai-Xia Wang; Yong-Qiang Tu; Zhen-Lei Song; Dao-Yi Yuan; Xiang-Dong Hu; Shao-Hua Wang; Shuanhu Gao Synthetically useful Wagner-Meerwein rearrangement of α-quaternary β-bromovinyl methyl ethers European Journal of Organic Chemistry, 2006, 12, 2691. Zhenlei Song; Yongqiang Tu; Shuanhu Gao; Yijun Jiang, Shuyu Zhang. Studies on the synthesis of morphinan alkaloid: preparation of the key allylic silyl ether precursor Chinese Chemical Letters, 2005, 16, 1445. Xue-Zhi Zhao; Lei Peng; Meng Tang; Yong-Qiang Tu; Shuanhu Gao Synthetic Studies of the HIV-1 Protease Inhibitive Didemnaketals: Precise and Stereocontrolled Synthesis of the Key Mother Spiroketal Tetrahedron Lett. 2005, 46, 6941. Li, Xin; Wang, Bao-Min; Zhao, Xue-Zhi; Shuanhu Gao; Tu, Yong-Qiang; Li, De-Run Extensive Studies on the AlEt3/THF-Promoted Diastereoselective Tandem Rearrangement Reduction of a-Hydroxy (Amino) Heterocyclopropane: An Efficient Approach to 2-Quaternary 1,3-Diheteroatom Units Chin. J. Chem. 2004, 22, 1177.

学术兼职

《Organic Chemistry Frontiers》青年编委《有机化学》编委