游松 - 沈阳药科大学 - 生命科学与生物制药学院

个人简介

游松，男，1963年生，1985年毕业于沈阳药科大学药学专业，理学学士。1998年获理学博士学位。现任沈阳药科大学微生物与细胞生物学教研室教授、博士生导师，生命科学与生物制药学院生物制药系主任；兼任科技部创新药物重大专项生物药品组评审专家、国家发改委医药价格评审中心评审专家、国家自然科学基金通信评审专家、中国酶工程学会专业委员会委员、中国药学会高级会员、辽宁省科技评审专家、辽宁省科技项目评审专家、沈阳市科技计划管理咨询专家、沈阳市政协委员、沈阳药科大学学报常务编委。

研究领域

留学归国以后从事生物催化与生物转化方面研究：①以生物催化剂的发现、改造及开发为目的，以蛋白质工程技术为核心，开发具有新功能、新性质、用于手性药物及其中间体合成的生物催化剂；②利用生物转化技术对活性天然产物进行结构修饰，以获得结构新颖的手性先导化合物用于创新药物的研究；③利用生物信息学平台，获取DNA及蛋白质信息，探索生物催化剂的序列特征，并通过分子对接进行计算机模拟，分析底物与蛋白质的作用方式和作用强度，为酶反应的优化以及药物设计提供理论支撑；④将有潜质的新型手性化合物用于活性筛选，并进一步展开对活性化物的临床前药学、药效学和毒理学研究。

近期论文

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1.QinF,QinB，MoriT,WangY,MengL,ZhangX,JiaX,AbeI,andYouS＊EngineeringofCandidaglabrataKetoreductase1forAsymmetricReductionofαHaloKetonesACSCatalysis.,2016,6,pp6135–6140(IF:10.6) 2.MuM,ZhangZ,ChengY,LiuG,ChenX,WuX,ZhuangC,LiuB,KongX,YouS＊Augmenterofliverregeneration(ALR)restrainsconcanavalinA-inducedhepatitisinmiceInternationalImmunopharmacology35(2016)280–286(IF:2.5) 3.WuX,LiuG,MuM,PengY,LiX,DengL,ZhangZ,ChenM,YouS＊andKongXAugmenterofliverregenerationgenetherapyusinganovelminicircleDNAvectoralleviatesliverfibrosisinratsHumanGeneTherapydoi:10.1089/hum.2016.006(IF:4.0) 4.QinB.,LiYX.,MengLX.,OuyangJP.,JinDN.,YouS＊.“Mirror-image”manipulationofcurdionestereoisomersscaffoldsbychemicalandbiologicalapproaches：DevelopmentofaSesquiterpenoidLibraryJournalofnaturalproducts2015,78(2):272-278.(IF:3.949) 5.XuYi,XinZhang,HyunjinJeong,YuMiShin,DongHoPark,SongYouandDong-KyooKim.AnovelbispidinoneanaloginducesS?phasecellcyclearrestandapoptosisinHeLahumancervicalcarcinomacellsOncologyReports2015,33:1526-1532,(IF:2.3) 6.WangJ.,OuyangJP.,LiuYP.,JiaX.,YouS.,HeJ.,DiX.DevelopmentofasensitiveLC–MS/MSmethodforthedeterminationofbilobalideinratplasmawithspecialconsiderationofexvivobilobalidestability:Applicationtoapreclinicalpharmacokineticstudy,JournalofPharmaceuticalandBiomedicalAnalysis2014,95:238–244.(IF:2.829) 7.CheQE.,QuanP.,MuM.,ZhangXF.,ZhaoHQ.,ZhangY.,YouS＊.,XiaoY.,FangL.Enantioselectiveskinpermeationofibuprofenenantiomers:mechanisticinsightsfromATR-FTIRandCLSMstudybasedonsyntheticenantiomersasnaphthalimidefluorescentprobes.ExpertOpinionOnDrugDelivery2014,11(10):1513-1523.(IF:4.116) 8.MaGZ.,XuZQ.,ZhangPF.,LiuJP.,HaoXL.,OuyangJP.,LiangP.,YouS＊.,JiaX.ANovelSynthesisofRasagilineviaaChemoenzymaticDynamicKineticResolution,OrganicProcessResearchDevelopment2014,18:1169?1174.(IF:2.549) 9.HuiJ.,YuXJ.,CuiXJ.,MuT.,LinJS.,NiP.,LinH.,YouS＊.,HuFQ.ConstructionofnovelchimericproteinsthroughthetruncationofSEC2andSakfromStaphylococcusaureus,Bioscience,Biotechnology,andBiochemistry2014,78(9):1514–1521.(IF:1.206) 10.ChenYN.,ZhangL.,QinB.,ZhangX.,JiaX.,YouS＊.AninsightintothecurdionebiotransformationpathwaybyAspergillusniger.NaturalProductResearch2014,1-7.(IF:1.225) 11.LiangP.,QinB.,MuM.,ZhangX.,JiaX,YouS.＊.Prelogandanti-PrelogstereoselectivityoftwoketoreductasesfromCandidaglabrata,BiotechnologyLetters2013,35(9),1469-1473.(IF:1.736) 12.QinB.,LiangP.,JiaX.,ZhangX.,MuM.,WangXY.,MaGZ.,JinD.-N.,YouS＊.DirectedevolutionofCandidaantarcticalipaseBforkineticresolutionofprofenesters.CatalysisCommunications2013,38:1-5.(IF:3.32) 13.SuX.,Xu,WZ.,Liu,X.;ZhuoRF.,WangCY.,ZhangX.,KakutaniK.,You,S＊.Theisolationandidentificationofalight-inducedproteininalfalfasproutsandthecloningofitsspecificpromoter,Gene2013,520:139.(IF:2.082) 14.YanJF.,ChenRB.,LinXZ.,YouS＊.,LiK.,RongH.,MaY.Overexpressionofacetyl-CoAsynthetaseincreasedthebiomassandfattyacidproportioninmicroalgaSchizochytrium,AppliedMicrobiologyandBiotechnology2013,97(5):1933-1939.(IF:3.811) 15.ZhouLN.,XuWZ,ChenYN.,ZhaoJ.,YuN.,FuBB.,YouS＊.StereoselectiveepoxidationofcurcumolandcurdionebyCunninghamellaelegansAS3.2028.CatalysisCommunications2012,28(5):191-195.(IF:3.32) 16.XuWZ.,JiaX.,LiuWB.,ZhangX.,ChenYN.,ZhouLN.,YouS＊.Identificationandcharacterizationofthreeimpuritiesinclocortolonepivalate,JournalofPharmaceuticalandBiomedicalAnalysis2012,62:167-171.(IF:2.829) 17.HuiJ.,DaiYJ.,BianYY.,LiH.,CuiXJ.,YuXJ.,YouS＊.,HuFQ.ConstructionofNovelBifunctionalChimericProteinsPossessingAntitumorandThrombolyticActivities,JournalofMicrobiologyBiotechnology2012,22(7):894–901.(IF:1.32) 18.YiX.-R.,SongM.,YuanY.-C.,ZhangX.-R.,ChenW.-Y.,LiJ.,TongM.-H.,LiuG.-Z.,YouS.,KongX.-P.Hepaticstimulatorsubstancealleviatestoxin-inducedandimmune-mediatedliverinjuryandfibrosisinrats.DigestiveDiseasesandSciences.2012,57:2079-2087.(IF:2.55) 19.XueX.,YouS.,ZhangQ.,WuY.,ZouG.-Z.,WangP.-C.,ZhaoY.-L.,XuY.,JiaL.,ZhangX.-N.,andLiangX.-J.MitaplatinIncreasesSensitivityofTumorCellstoCisplatinbyInducingMitochondrialDysfunction.MolecularPharmaceutics.2012,634-644.(IF:4.787) 20.SongM.,YiX.-R.,ChenW.-Y.,YuanY.-C.,ZhangX.-R.,LiJ.,TongM.-H.,LiuG.-Z.,YouS＊.,KongX.-P.Augmenterofliverregeneration(ALR)genetherapyattenuatesCCl4-inducedliverinjuryandfibrosisinrats.BiochemicalandBiophysicalResearchCommunications,2011,415:152-156.(IF:2.281) 21.XuW.-Z.,ZhouL.-N.,MaX.-N.,ChenY.-N.,QinB.,ZhaiX.-W.,YouS＊.TherapeuticEffectsofCombinationofPaeoniflorinandAlbiflorinfromPaeoniaRadixonRadiationandChemotherapy-inducedMyelosuppressioninMiceandRabbits.TheAsianPacificJournalofCancerPrevention,2011,2(8):2031-7.(IF:1.5)