尹然 - 沈阳药科大学

个人简介

尹然，女，博士，副教授。2003年毕业于沈阳药科大学，获药学(日语)专业理学学士学位，同年考取沈阳药科大学药物分析专业研究生，2005年获得硕博连读资格，2008年获药物分析学博士学位，毕业后留校任教。2012年被聘为沈阳药科大学副教授，现为药物分析专业硕士生导师。研究方向：中药质量控制方法、药效物质基础与作用机制研究，药品质量标准制定，药代动力学研究等。作为课题负责人主持了国家自然科学基金青年基金项目1项，辽宁省自然科学基金项目1项，辽宁省教育厅项目1项，沈阳药科大学中青年骨干人才培育计划项目1项；另外，作为项目主要成员参与承担国家自然科学基金项目，国家科技重大专项子课题，省、市各级科研项目共15项。目前已在国内外学术期刊和学术会议上发表研究论文36篇，其中SCI收录23篇，获辽宁省自然科学学术成果奖（学术论文类）1项；沈阳市自然科学学术成果奖（学术论文类）2项。

研究领域

研究方向一：基于系统生物学方法开展中药药效物质基础和作用机制研究研究方向二：中药质量控制方法和药品质量标准研究研究方向三：体内药物分析方法和药代动力学研究

近期论文

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1.FeiHan,YantingLi,LiMa,TianfengLiu,YawenWu,RuiXu,AihuaSong,RanYin.ArapidandsensitiveUHPLC-FT-ICRMS/MSmethodforidentificationofchemicalconstituentsinRhodiolacrenulataextract,ratplasmaandratbrainafteroraladministration.Talanta.2016,160:183-193.(IF=4.035) 2.FeiHan,Yan-tingLi,Xin-juanMao,Xiao-shuZhang,JiaoGuan,Ai-huaSong,RanYin.Metabolicprofileofsalidrosideinratsusinghigh-performanceliquidchromatographycombinedwithFouriertransformioncyclotronresonancemassspectrometry.AnalyticalandBioanalyticalChemistry.2016,408(7)：1975-1981.(IF=3.125) 3.FeiHan,YantingLi,XinjuanMao,RuiXu，RanYin.CharacterizationofchemicalconstituentsinRhodiolaCrenulatebyhigh-performanceliquidchromatographycoupledwithFourier-transformioncyclotronresonancemassspectrometer(HPLC-FT-ICRMS).JMassSpectrom.2016,51:363-368.(IF=2.541) 4.HeyunZhu,KaishunBi,FeiHan,JiaoGuan,XiaoshuZhang,XinjuanMao,LongshanZhao,QingLi,XiaohongHou,RanYin.IdentificationoftheabsorbedcomponentsandmetabolitesofZhi-Zi-Da-Huangdecoctioninratplasmabyultra-highperformanceliquidchromatographycoupledwithquadrupole-time-of-flightmassspectrometry.JPharmBiomedAnal.2015,111:277-287.(IF=2.979) 5.Ke-LinChen,Kai-ShunBi,FeiHan,He-YunZhu,Xiao-ShuZhang,Xin-JuanMao,RanYin.EvaluationoftheprotectiveeffectofZhi-Zi-da-Huangdecoctiononacuteliverinjurywithcholestasisinducedbyα-naphthylisothiocyanateinrats.JEthnopharmacol.2015,172:402-409.(IF=2.998) 6.ZhengTang,RanYin,KaishunBi,HeyunZhu,FeiHan,KelinChen,FenrongWang.Simultaneousquantitativedeterminationof20activecomponentsinthetraditionalChinesemedicineformulaZhi-Zi-Da-Huangdecoctionbyliquidchromatographycoupledwithmassspectrometry:applicationtostudythechemicalcompositionvariationsindifferentcombinations.BiomedChromatogr.2015,29(9):1406-1414.(IF=1.723) 7.HeyunZhu,KaishunBi,FeiHan,JiaoGuan,ZhengTang,KelinChen,LongshanZhao,QingLi,RanYin,XiaohongHou.Simultaneousdeterminationoftwoiridoidglycosides,twoanthraquinonesandfourflavonoidglycosidesofZhi-Zi-Da-HuangdecoctioninratplasmabyUFLC-MS/MS:Applicationtoacomparativepharmacokineticstudyinnormalandcholestaticliverinjuryrats.JChromatogrB.2014,960:116-125.(IF=2.694) 8.HeyunZhu,RanYin,FeiHan,JiaoGuan,XiaoshuZhang,XinjuanMao,LongshanZhao,QingLi,XiaohongHou,KaishunBi.CharacterizationofchemicalconstituentsinZhi-Zi-Da-Huangdecoctionbyultrahighperformanceliquidchromatographycoupledwithquadrupoletime-of-flightmassspectrometry.JSepSci.2014,37(23):3489-3496.(IF=2.594) 9.RanYin,FeiHan,ZhengTang,RanLiu,XuZhao,XiaohuiChen,KaishunBi.UFLC–MS/MSmethodforsimultaneousdeterminationofluteolin-7-O-gentiobioside,luteolin-7-O-β-D-glucosideandluteolin-7-O-β-D-glucuronideinbeagledogplasmaanditsapplicationtoapharmacokineticstudyafteradministrationoftraditionalChinesemedicinalpreparation:Kudieziinjection.JPharmBiomedAnal.2013,72:127-133.(IF=2.947) 10.RanYin,Xin-XiuDeng,FeiHan,ZhenSong,Wei-MingCheng,Xiao-HuiChen,Kai-ShunBi.DeterminationoffivecomponentsinIxerissonchifoliabyhighperformanceliquidchromatography.JournalofPharmaceuticalandBiomedicalAnalysis.2007,43(4):1364-1369.(IF=2.761)