个人简介
徐海燕,女,博士,副教授。1996年毕业于沈阳药科大学,获药学学士学位,2001年于同校获药物分析硕士学位,2006年获沈阳药科大学药物分析博士学位,毕业后赴美国UniversityofHouston进行博士后研究。2006年被聘为沈阳药科大学副教授,从2014年起负责《JournalofPharmaceuticalandBiomedicalAnalysis》、《MolecularNutritionandFoodResearch》、《JournalofChromatographyB》和《BiomedicalChromatography》等期刊的英文审校工作。作为课题负责人主持了国家自然科学基金青年基金项目1项,辽宁省自然科学基金项目1项、辽宁省教育厅专项基金1项。另外,作为项目骨干成员承担国家自然科学基金面上项目2项。目前已在AAPSJ,MolPharm,JAgricFoodChem,JPharmBiomedAnal,JChromatogrB,JEthnopharmacol等期刊发表论文10余篇。
研究领域
研究方向一:具有生物活性的皂苷类天然产物吸收及代谢机制研究
研究方向二:皂苷类天然产物立体选择性动力学机制研究
研究方向三:药物代谢与药物动力学研究
近期论文
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1.Liu,Y.;Guo,J.;Liu,Y.;Wang,X.;Wang,Y.;Jia,X.;Wei,G.;Chen,L.;Xiao,J.;Cheng,M.Au(I)-CatalyzedTripleBondAlkoxylation/DienoletherAromaticity-DrivenCascadeCyclizationtoNaphthalenes,Chem.Commun.,DOI:10.1039/C4CC00464G.(IF=6.378)
2.ZhangD,LeiT,LvC,ZhaoH,XuH,LuJ.PharmacokineticstudiesofactivetriterpenoidsaponinsandthetotalsecondarysaponinfromAnemoneraddeanaRegel.JChromatogrBAnalytTechnolBiomedLifeSci.2017;1044-1045:54-62.IF=2.687
3.ShaoN,JiangH,WangX,YuanB,JinY,SongM,ZhaoY,XuH.Stereoselectivepharmacokineticsof25-methoxyl-dammarane-3beta,12beta,20-triolanditsactivedemethyl-metaboliteepimersinratsafteroralandintravenousadministration.Fitoterapia2017;116:139-145.IF=2.408
4.LiuJ,MengF,LiZ,YuL,PengS,GuoJ,XuH.Simultaneousquantificationoftizoxanideandtizoxanideglucuronideinmouseplasmabyliquidchromatography-tandemmassspectrometry.BiomedChromatogr.2016;30(11):1744-1749.IF=1.729
5.JinY,GuoX,YuanB,YuW,SuoH,LiZ,XuH.DispositionofAstragalosideIVviaenterohepaticcirculationisaffectedbytheactivityoftheintestinalmicrobiome.JAgricFoodChem.2015;63:6084–93.IF=2.857
6.SuiW,YangX,YuW,JinY,LuanX,WangX,XuH.AvalidatedLC-MS/MSmethodfortherapidquantificationofvilazodoneinratplasma:Applicationtoapharmacokineticstudy.JPharmBiomedAnal.2014;98:228–234.IF=2.979
7.XuH,GanJ,LiuX,WuR,JinY,LiM,YuanB.Gender-dependentpharmacokineticsoflignansinratsaftersingleandmultipleoraladministrationofSchisandrachinensisextract.JEthnopharmacol.2013;147:224-231.IF=2.939
8.YuanB,LiL,FuY,JinY,GuoL,XuH.DevelopmentandvalidationofaLC-MS/MSmethodforquantificationoftheregioisomersofdihydroxybutyletherinhumanplasma.JChromatogrBAnalytTechnolBiomedLifeSci.2012;911:27-33.IF=2.487
9.YuanB,ZhenH,JinY,XuL,JiangX,SunS,LiC,XuH.Absorptionandplasmadispositionofgenistindifferfromthoseofgenisteininhealthywomen.JAgricFoodChem.2012;60:1428-1436.IF=2.906
10.YuanB,WangL,JinY,ZhenH,XuP,XuY,LiC,XuH.RoleofmetabolismintheeffectsofgenisteinanditsphaseIIconjugatesonthegrowthofhumanbreastcelllines.AAPSJ.2012;14:329-344.IF=4.386
11.XuH,KulkarniKH,SinghR,YangZ,WangSW,TamVH,HuM.Dispositionofnaringeninviaglucuronidationpathwayisaffectedbycompensatingeffluxtransportersofhydrophilicglucuronides.MolPharm.2009;6:1703-1715.IF=5.408