个人简介
熊志立,女,特聘教授,博士研究生导师。1996年毕业于天津医科大学药学院,获理学学士学位,2003年获沈阳药科大学药学专业博士学位,毕业后留校任教,在分析化学教研室工作至今。2005年被聘为沈阳药科大学药物分析专业和分析化学专业硕士研究生导师,2011年9月作为访问学者去美国UniversityofGeorgia,Athens交流学习1年,2013年5月任分析化学教研室主任。2018年4月被聘为沈阳药科大学药物分析专业博士研究生导师。作为课题负责人主持了国家自然科学基金面上项目1项,国家自然科学基金青年基金项目1项,辽宁省博士启动基金1项,辽宁省科学技术计划项目1项,辽宁省高等学校杰出青年学者成长计划1项,沈阳药科大学科研专项基金2项;作为项目骨干成员参加国家自然科学基金重点项目1项,面上项目及青年基金项目4项。另外,主持横向科研项目数项。目前在国内外核心学术期刊发表研究论文130余篇,其中以第一作者或通讯作者在JournalofChromatographyB,JournalofPharmaceuticalandBiomedicalAnalysis,Talanta,JournalofEthnopharmacology等SCI期刊发表科研论文20余篇。
研究领域
研究方向一:体内药物分析及药物动力学研究
研究方向二:代谢组学在药物研究中的应用
近期论文
查看导师新发文章
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1.ZhiliXiong,YanminWang,LangLang,ShupingMa,LongshanZhao,WeiXiao,YanjuanWang.TissuemetabolomicprofilingtorevealthetherapeuticmechanismofreduninginjectiononLPS-inducedacutelunginjuryrats.RoyalSocietyofChemistryAdvances(RSCAdvances).2018,8,10023–10031(SCI,IF=3.108).
2.XiaoWu,YueHuang,JinghanSun,YongqingWen,FengQin,LongshanZhao,ZhiliXiongAHILIC-UHPLC-MS/MSuntargetedurinarymetabonomicscombinedwithquantitativeanalysisoffivepolarbiomarkersonosteoporosisratsafteroraladministrationofGushudan.JournalofChromatographyB,2018,1072:40-49.(SCI,IF=2.603)
3.YunhaiBo,LijuanWang,XiaoWu,LongshanZhao,JingyuYang,ZhiliXiong,ChunfuWu.DevelopmentandvalidationofaUHPLC–MS/MSmethodforthesimultaneousdeterminationoffivebioactiveflavonoidsinratplasmaandcomparativepharmacokineticstudyafteroraladministrationofXiaochaihuTangandthreecompatibilities.JournalofSeparationScience.2017,40(9):1896–1905.(SCI,IF=2.557)
4.ZhiliXiong,JieYang,YueHuanga,KuoZhang,YunhaiBo,XiumeiLu,GuangyueSu,JieMa,JingyuYang,LongshanZhao,,ChunfuWub,Serummetabonomicsstudyofanti-depressiveeffectofXiao-Chai-Hu-Tangonratmodelofchronicunpredictablemildstress.JournalofChromatographyB.2016,1029–1030:28–35.(SCI,IF=2.687)
5.QinFeng,YinBincan,WangLijuan,LiKunjie,LiFamei,XiongZhili.Quantificationoftrantinterol,itstwometabolitesandtheirprimaryconjugatedmetabolitesinhumanplasmabyultra-high-performanceliquidchromatography-tandemmassspectrometryanditsapplicationtoapharmacokineticstudy.Journalofpharmaceuticalandbiomedicalanalysis,2016,117:413-418(SCI,IF=3.255)
6.YueHuang,YunhaiBo,XiaoWu,QiuyiWang,FengQin,LongshanZhao,ZhiliXiong.AnintegratedserumandurinarymetabonomicresearchbasedonUPLC-MSandtherapeuticeffectsofGushudanonprednisolone-inducedosteoporosisrats.JournalofChromatographyB.2016,1027:119-130.(SCI,IF=2.687)
7.ChengyingWang,HongSun,ShaojieWang,ZhongguiHe,LongshanZhao,ZhiliXiong,FengQinDevelopmentandvalidationofachiralliquidchromatographymethodforthedeterminationofMP3950enantiomers,ahighselective5-HT4receptoragonist,inratplasmaanditsapplicationtostereoselectivepharmacokineticstudy.JournalofChromatographyB.2016,1033:49–54.(SCI,IF=2.687)
8.LongshanZhao,ZhiliXiong,XiumeiLu,ShuningZheng,FangWang,LinGe,GuangyueSu,JingyuYang,ChunfuWu.Metabonomicevaluationofchronicunpredictablemildstress-inducedchangesinratsbyinterventionoffluoxetinebyHILIC-UHPLC/MS.PosOne,10(6),pe0129146.(SCI,IF=3.234)
9.YuejuanLu,NingLi,YingDeng,LongshanZhao,XingjieGuo,FameiLi,ZhiliXiong.Simultaneousdeterminationoficariin,naringinandostholeinratplasmabyUPLC-MS/MSanditsapplicationforpharmacokineticstudyafteroraladministrationofGushudancapsules.JournalofChromatographyB.2015(993-994):75-80.(SCI,IF=2.729)
10.XinyuLiu,ShangshangZhang,XiumeiLu,ShuningZheng,FameiLi,ZhiliXiong.Metabonomicstudyontheanti-osteoporosiseffectofRhizomaDrynariaeanditsactionmechanismusingultra-performanceliquidchromatography-tandemmassspectrometry.JournalofEthnopharmacology2012,139(1):311-317.(SCI,IF=3.097)
学术兼职
1.辽宁省优秀硕士学位论文指导教师;
2.《沈阳药科大学学报》编委;
3.《JournalofChromatographyB》、《BiomedicalChromatography》、《沈阳药科大学学报》、《中国中药杂志》等学术期刊审稿人。