个人简介
杨明世,沈阳药科大学教授、博士生导师、课题组长。在药物制剂研究领域,主要致力于基于颗粒设计的生物大分子类药物(蛋白,多肽及siRNA)的递送、可连续性生产、未来个体化联合给药的设计以及难溶性药物口服生物利用度的提高。先后在Biomaterials,Pharm.Res.等杂志上发表论文79篇(其中SCI收载64篇),国内外会议摘要和学报69篇,参编著作5部。自2009年起,已培养博士后1名,博士生7名,硕士生16名,接收访问学者3名。目前正指导博士后1名,博士生7名,硕士生6名。
研究领域
1.基于颗粒设计的生物大分子类药物(蛋白,多肽及siRNA)的递送;
2.可连续性生产;
3.未来个体化联合给药的设计以及难溶性药物口服生物利用度的提高。
近期论文
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1.NBorkar,RHolm,MYang,AMüllertz,HMu.InvivoEvaluationofLipid-basedFormulationsforOralDeliveryofApomorphineanditsDiesterProdrugs.IntJPharm2016Inpress
2.SJi,PWThulstrup,HMu,SHHansen,MvandeWeert,JRantanen,MYang*.Effectofethanolasaco-solventonthestabilityandaerosolperformanceofspray-driedlysozyme.IntJPharm2016Inpress
3.NBorkar,ZChen,LSaaby,AMüllertz,AEHåkansson,CSchönbeck,MYang,RHolm,HMu.Apomorphineanditsesters:DifferencesinCaco-2cellpermeabilityandchylomicronaffinity.IntJPharm2016,509(1-2):499-506.
4.YCao;L-LShi;Q-RCao;MYang;J-HCui.In-VitroCharacterizationandOralBioavailabilityofOrganicSolvent-freeSolidDispersionsContainingTelmisartan.IranianJournalofPharmaceuticalResearch(2016),15(2):385-394.http://ijpr.sbmu.ac.ir/article_1839_abe0fb77f186720ebf50e7d8179bc020.pdf
5.WLiu,XWang,RChen,KZhang,YLi,YLi,DSi,JGong,DYin,YWang,ZWei,MYang.Effectofageonthepharmacokineticsofpolymorphicnimodipineinratsafteroraladministration.ActaPharmaceuticaSinicaB(2016),http://dx.doi.org/10.1016/j.apsb.2016.07.010
6.DXia,NShrestha,JvandeStreek,HMu,MYang*.Spraydryingoffenofibrateloadednanostructuredlipidcarriers.AsianJPharmSci2016,11(4)507–515(doi:10.1016/j.ajps.2016.01.001)
7.FWan,MYang*.DesignofPLGA-baseddepotdeliverysystemsforbiopharmaceuticalspreparedbyspraydrying.IntJPharm498(2016)82–95.
8.WWang,Q.Zhou,S-PSun,J.A.Denman,TGengenbach,NBarraud,S.A.Rice,JLi,MYang*,H-KChan.EffectsofSurfaceCompositionontheAerosolisationandDissolutionofInhaledAntibioticCombinationPowdersConsistingofColistinandRifampicin.AAPSJ2016Mar24;18(2):372-84.DOI:10.1208/s12248-015-9848-z
9.ABohr,JWater,MBeck-Broichsitter,MYang.Nanoembeddedmicroparticlesforstabilizationanddeliveryofdrug-loadednanoparticles.CurrentPharmaceuticalDesign,2015,21,5829-5844.
10.WGuo,PQuan,LFang,DCun,MYang.SustainedreleasedonepezilloadedPLGAmicrospheresforinjection:Preparation,invitroandinvivostudy",AsianJPharmSci.2015,10,405–414.doi:10.1016/j.ajps.2015.06.001.
学术兼职
2015,ActaPharmaceuticaSinicaB,编委
2014,复旦大学智能化递药教育部和全军重点实验室,高级访问学者
2013,中国颗粒协会生物颗粒分会,委员
2011,JournalofPharmaceuticalTechnologyandDrugResearch,编委
2011,AsianJournalofPharmaceuticalScience,编委