个人简介
王钝,女,博士,副教授。1998年毕业于沈阳药科大学,获药物化学硕士学位,2003年于同校获药物化学博士学位,2004年被聘为沈阳药科大学副教授,2012年赴UniversityofNorthCarolinaatChapelHill作为访问学者工作。沈阳市高层次人才领军人才,国家自然科学基金函审评议专家,辽宁省科学技术计划项目评审专家,沈阳市科学技术计划项目评审专家,沈阳市科技管家,《中国药物化学杂志》双语出版论文翻译专家,《JournalofExperimental&ClinicalCancerResearch》、《JournalofCancerTherapy》及《Asia-PacificJournalofPharmaceuticalSciences》审稿人。作为项目负责人主持辽宁省自然科学基金重点项目等省级项目八项、市级项目四项,校科研专项基金1项,横项课题4项;作为项目第二负责人承担“十二五”国家重大科技专项项目1项、国家自然科学基金面上项目3项。目前已在ACSAppliedMaterials&Interfaces,JournalofControlledrelease,CancerLetters,MolecularPharmaceutics等期刊作为第一作者或通讯作者发表论文22篇,累积影响因子65.2,其中IF≥5四篇,最高IF8.546。
研究领域
研究方向一:靶向肿瘤前药设计与研究
研究方向二:纳米自组装抗肿瘤前药的设计与研究
研究方向三:基于活性的天然产物结构修饰及药效学研究
近期论文
查看导师新发文章
(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
1.KaiyuanWang,BinYang,HaoYe,XuanboZhang,HangSong,XiaWang,NaLi,LinWei,YuWang,HaotianZhang,QimingKan,ZhonguiHe,DunWang,JinSun.Self-strengthen-edOxidation-responsivebioactivatingprodrug-nanosystemwithsequentialandsynergis-ticallyfacilitateddrugreleasefortreatmentofbreastcnacer.ACSAppliedMaterials&Interfaces.2019,11,18914-18922.(IF=8.456)
2.Xiao-GuangYang#,Yan-HuaMou#,Yong-JunWang,JianWang,Yan-YuLi,Rui-HengKong,MengDing,DunWang,ChunGuo.Design,synthesis,andevaluationofmonoamineoxidaseAinhibitors-indocyaninedyesconjugatesastargetedantitumoragents.Molecules,2019,24(7):1400.(IF3.060)
3.ZhaomengWang,MengchiSun,TianLiu,ZisenGao,QingHe,XiaoTan,YanxianHou,JinSun,DunWang,ZhongguiHe.Co-amorphoussoliddispersionsystemsoflacidipine-spironolactonewithimproveddissolutionrateandenhancedphysicalstability.AsianJournalofPharmaceuticalSciences.2019,14:95-103.(IF4.016)
4.YujieSu,YuanLiu,XiangtingXu,JianpingZhou,LinXu,XiaoleXu,DunWang,MinLi,KerongChen,WeiWang.On-demandversatileprodrugnanomicellefortumor-specificbioimagingandphotothermal-chemosynergisticcancertherapy.ACSAppliedMaterials&Interfaces.2018,10,38700-38714.(IF=8.456)
5.QingzhiLv,XiaoguangYang,MenglinWang,JinchengYang,ZhilinQin,QimingKan,HaotianZhang,YongjunWang,DunWang,ZhongguiHe.Mitochondria-TargetedProstateCancerTherapyUsingaMonoamineOxidaseAInhibitor-Near-InfraredFluorescenceDyeConjugate.JournalofControlledrelease,2018,279:234-242.(IF=7.901)
6.DunWang#,QiangFu#,JinglingTang,MichaelHackett,YongjunWang&FengLiu.Molecular-matchedmaterialsforanticancerdrugdeliveryandimaging.Nanomedicine,2015,10(19):3003-3013.(IF=4.889)
7.YongjunWang#,DunWang#,QiangFu,DanYan,KellyRacette,ZhongguiHe,FengLiu.Shaped-controlledpaclitaxelnanoparticleswithmultiplemorphologies:rod-shaped,worm-like,sphericalandfingerprint-like.MolecularPharmaceutics.2014,11,3766-3771.(IF=4.384)
8.XinggangYang#,DunWang#,YanMa,QiangZhao,JohnKFallon,DanLiu,XianEmmaXu,YongjunWang,ZhongguiHe,FengLiu.Theranosticnanoemulsion:codeliveryofhydrophobicdrugandhydrophilicimagingprobeforcancertherapyandimaging.Nanomedicine,2014,9(18):2773-2785.(IF=4.383)
9.JinglingTang#,QiangFu#,YongjunWang,KellyRacette,DunWang,FengLiuVitaminEreversesmultidrugresistanceinvitroandvivo.CancerLetters,2013,336,149~157.(IF=5.016)
10.DunWang#,JinglingTang#,YongjunWang,SrinivasRamishetti,QiangFu,KellyRacette,FengLiu.MultifunctionalNanoparticlesBasedonaSingle-MoleculeModificationtoTreatDrug-ResistantCancer.MolecularPharmaceutics.2013,10,1465-1469.(IF=4.787)
学术兼职
1.沈阳市高层次人才领军人才;
2.入选“辽宁省高等学校创新人才支持计划”
3.入选沈阳市“中青年科技创新人才支持计划”
4.国家自然科学基金函审评议专家
5.辽宁省科学技术计划项目评审专家
6.沈阳市科学技术计划项目评审专家
7.沈阳市科技管家
8.《中国药物化学杂志》双语出版论文翻译专家