关奇 - 沈阳药科大学 - 制药工程学院

个人简介

关奇，男，博士，特聘副教授。2010年毕业于沈阳药科大学，获制药工程学士学位，2015年于同校获药物化学博士学位。2017年被聘为沈阳药科大学副教授。作为课题负责人主持了国家自然科学基金青年基金项目1项、辽宁省科技厅项目1项、辽宁省教育厅项目1项、沈阳市科技计划项目1项；另外，作为项目骨干成员承担国家自然科学基金应急项目1项。目前已在Green.Chem.,Cancer.Lett.,Eur.J.Med.Chem.,MedChemComm,Bioorg.Med.Chem.Lett.,等期刊发表论文10余篇。

研究领域

研究方向一：抗肿瘤及抗痛风创新药物研究研究方向二：绿色化学合成方法研究及生物活性分子的新型构建方法研究抗肿瘤及抗痛风创新药物研究与绿色化学合成方法研究

近期论文

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1.QiGuan,MingyangJiang,JunhuiWu,YanpengZhai,YueWu,KaiBao*,WeigeZhang*.Directcyclebetweenco-productandreactant:anapproachtoimprovetheatomeconomyanditsapplicationinthesynthesisandprotectionofprimaryamines.Greenchemistry.18(2016)5794-5799.(IF=9.125) 2.QiGuan,ChunmingHan,DaiyingZuo,Min’anZhai,ZengqiangLi,QianZhang,YanpengZhai,XueweiJiang,KaiBao,YingliangWu*,WeigeZhang*.SynthesisandEvaluationofBenzimidazoleCarbamatesBearingIndoleMoietiesforAntiproliferativeandAntitubulinActivities.EuropeanJournalofMedicinalChemistry.2014,87,306-315(IF=4.519) 3.QiGuan,FushanYang,DandanGuo,JingwenXu,MingyangJiang,ChunjiangLiu,KaiBao,YingliangWu*,WeigeZhang*.SynthesisandBiologicalEvaluationofNovel3,4-Diaryl-1,2,5-selenadiazolAnaloguesofCombretastatinA-4.EuropeanJournalofMedicinalChemistry.2014,87,1-9(IF=4.519) 4.QiGuan,ZengjinCheng,XiaoxueMa,LijieWang,DongjieFeng,YuanhangCui,KaiBao,LanWu*,WeigeZhang*.SynthesisandBioevaluationof2-Phenyl-4-methyl-1,3-selenazole-5-carboxylicAcidsasPotentXanthineOxidaseInhibitors.EuropeanJournalofMedicinalChemistry.2014,85,508-516(IF=4.519) 5.QiGuan,DaiyingZuo,NanJiang,HuanQi,YanpengZhai,ZhaoshiBai,DongjieFeng,LeiYang,MingyangJiang,KaiBao,ChangLi,YingliangWu*,WeigeZhang*.Microwave-assistedSynthesisandBiologicalEvaluationof3,4-DiarylMaleicAnhydride/N-SubstitutedMaleimideDerivativesasCombretastatinA-4Analogues.Bioorganic&MedicinalChemistryLetters.2015,25(3),631-634(IF=2.454) 6.QiGuan1,DongjieFeng1,ZhaoshiBai,YuanhangCui,DaiyingZuo,Min’anZhai,XueweiJiang,WenboZhou,KaiBao,YingliangWu*,WeigeZhang*.Microwave-assistedSynthesis,MolecularDockingandAntiproliferativeActivityof3/5-Aryl-5/3-(3,4,5-trimethoxybenzoyl)-1,2,4-oxadiazolDerivatives.MedicinalChemistryCommunications.2015,6(8),1484-1493(IF=2.608) 7.AilongShi,DefaWang,HeWang,YueWu,HaiqiuTian,QiGuan*,KaiBao*,WeigeZhang*.Synthesisandbioevaluationof2-phenyl-5-methyl-2H-1,2,3-triazole-4-carboxylicacid/carbohydrazidederivativesaspotentxanthineoxidaseinhibitors.RSCAdvances.6(2016)114879-114888.(IF=3.108)