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个人简介

研究课题: 高分辨率荧光成像仪的研制与产业化,科技部重大科学仪器设备开发重点专项,2016.7-2020.6,子课题; 鞘氨醇激酶I在药物诱导的急性肝损伤和炎症中的分子机制研究,国家自然科学基金,2018/10-2021/12; 鞘氨醇信号对中枢神经系统炎症和免疫细胞招募调控机制的研究,国家自然科学基金,2015/10-2018/12; 环境内分泌干扰物对女性生殖功能的影响及其分子机制,国家科技部重大科学研究计划(973)项目,2014/05-2018/6,2014CB943303-1; 补体成分C3、C5介导中枢神经系统炎症中血管内皮激活和中性粒细胞招募,国家自然科学基金,2013/10-2017/12; 中枢神经系统炎症状态下补体C3和C5对中性粒细胞招募的影响,教育部博士学科点基金(博导类),2013/11-2016/12; 活体显微镜研究CXC趋化因子在CNS中招募中性粒细胞,国家自然科学基金,2011/10-2015/12。

研究领域

炎症免疫应答和细胞迁移

近期论文

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论文发表: ShiD,TianT,YaoS,CaoK,ZhuX,ZhangM,WenS,LiL,SuD,ShiMQ,ZhouH*FTY720attenuatesbehavioraldeficitsinamurinemodelofsystemiclupuserythematosus.BrainBehavImmun.2018Mar13.pii:S0889-1591(18)30057-6 CaoK,LiaoX,LuJH,WuFJ,ZhuX,ShiD,WenS,LiuLZhouH*IL-33/ST2playsacriticalroleincerebralendothelialcellactivationandmicroglia-mediatedneuroinflammationmodulation.JNeuroinflam.2018May4;15(1):136.doi:10.1186/s12974-018-1169-6. XuC,ZhangC,JiJ,WangC,YangJ,GengB,ZhaoT,ZhouH,MuX,PanJ,HuS,LvY,ChenX,WenH,YouQ.*CD36deficiencyattenuatesimmune-mediatedhepatitisinmicebymodulatingtheproapoptoticeffectsofCXCL10.Hepatology2017Dec8.doi:10.1002/hep.29716.[Epubaheadofprint]. ZhaoY,ShiD,CaoK,WuF,ZhuX,WenS,YouQ,Zhan保存gK,LiuL,ZhouH*Fingolimodtargetscerebralendothelialactivationtoblockleukocyterecruitmentinthecentralnervoussystem.JLeukBiol.2018Jan;103(1):107-118. LiX,LiaoX,ZhangJ,WangY,WeiP,WuF,ShiD,LiuL,YeN,ZhouH*BisphenolAaffectstrophoblastinvasionbyinhibitingCXCL8expressionindecidualstromalcells.MolCellEndocrin.2017Jul20.(17)30390-8. WuF,LiuL,ZhouH*Endothelialcellactivationininflammationofcentralnervoussystem.JLeukBiol.2017May;101(5):1119-1132. SunD,ZhangM,LiuG,WuH,LiC,ZhouH,ZhangX,ShiM*.IntravascularclearanceofdisseminatingCryptococcusneoformansinthebraincanbeimprovedbyenhancingneutrophilrecruitmentinmice.EurJImmunol.2016Jul;46(7):1704-14. WuF#,ZhouQ#,DingX,ShiDY,ZhuX,HuW,LiuL,ZhouH*ComplementcomponentC3aplaysacriticalroleinendothelialactivationandleukocyterecruitmentintothebrain.JNeuroinflam2016Jan28;13(1):23.doi:10.1186/s12974-016-0485-y.Commentson“FocusonComplement”(InternationalComplementSociety)March1,2016 ZhuXX,ShiD,LiXQ,GongWJ,WuFJ,GuoXJ,XiaoH,LiuL,ZhouH*TLRsignalingaffectsspermmitochondrialfunctionandmotilityviaphosphatidylinositol3-kinaseandglycogensynthasekinase-3α.CellSignal.2016Mar;28(3):148-156. ZhangMS#,SunDL#,LiuGG,WuH,ZhouH,ShiMQ*Real-timeinvivoimagingrevealstheabilityofneutrophilstodirectlyremoveCryptococcusneoformansfromthebrainvasculature.JLeukBiol.2016Mar;99(3):467-73. LiL#,WangY#,GaoW,YuanC,ZhangS,ZhouH,HuangM,YaoX*.KlothoreductioninalveolarmacrophagescontributestoCSE-inducedinflammationinchronicobstructivepulmonarydisease.JBiolChem.2015Nov13;290(46):27890-900. WuF,ZhaoY,JiaoT,ShiD,ZhuX,ZhangM,ShiM,ZhouH*CXCR2isessentialforcerebralendothelialactivationandleukocyterecruitmentduringneuroinflammation.JNeuroinflam2015May21;12(1):98.doi:10.1186/s12974-015-0316-6. LangerHF#,*,ChoiEY#,ZhouH,SchleicherR,ChungKJ,TangZ,GöbelK,BdeirK,ChatzigeorgiouA,WongC,BhatiaS,KruhlakMJ,RoseJW,BurnsJB,HillKE,QuH,ZhangY,LehrmannE,BeckerKG,WangY,SimonDI,NieswandtB,LambrisJD,LiX,MeuthSG,KubesP,ChavakisT.Plateletscontributetothepathogenesisofexperimentalautoimmuneencephalomyelitis.CircRes.2012,110(9):1202-1210. ShiM,LiS,ZhengC,JonesGJ,KimKS,ZhouH,KubesP,ModyCH*.Real-timeimagingoftrappingandureasedependenttransmigrationofCryptococcusneoformansinmousebrain.JClin.Invest.2010,120(5):1683-1693. LeeWY,MoriartyTJ,WongCH,ZhouH,StrieterRM,vanRooijenN,ChaconasG,KubesP*.AnintravascularimmuneresponsetoBorreliaburgdorferiinvolvesKupffercellsandiNKTcells.Nat.Immunol.2010,11(4):295-302. ZhouH,AndoneguiG,WongCH,KubesP*.RoleofendothelialTLR4forneutrophilrecruitmentintocentralnervoussystemmicrovesselsinsystemicinflammation.JImmunol.2009,183(8):5244-5250. AndoneguiG#,ZhouH#,BullardD,KellyMM,MullalySC,McDonaldB,LongEM,RobbinsSM,KubesP*.MicethatexclusivelyexpressTLR4onendothelialcellscanefficientlyclearalethalsystemicGram-negativebacterialinfection.JClinInvest.2009,119(7):1921-1930.ResearchhighlightedinNatRevImmunol.Aug.2009,9:532 ZhouH,LapointeBM,ClarkSR,KubesP*.ArequirementformicroglialTLR4inleukocyterecruitmentintobraininresponsetoLPS.JImmunol.2006,177(11):8103-8110.

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