近期论文
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近五年代表性论文、专利
1.SunL,LiH,ChenJ,DehennautV,ZhaoY,YangY,IwasakiY,Kahn-PerlesB,LeprinceD,ChenQ,ShenA,XuY*.ASUMOylationdependentpathwayregulatesSIRT1transcriptionandcancermetastasis.JNatCancerInst.2013June19;105(12):887-98
2.YangY1,ChenD,YuanZ,FangF,ChengX,XiaJ,FangM,XuY*,GaoY.Megakaryocyticleukemia1(MKL1)tiestheepigeneticmachinerytohypoxiainducedtransactivationofendothelin-1.NucleicAcidsRes.2013July8;41(12):5991-6004.
3.TianW,XuH,FangF,ChenQ,XuY*,ShenA.Brahmarelatedgene1(Brg1)bridgesepigeneticregulationofpro-inflammatorycytokineproductiontosteatohepatitis.Hepatology.2013August;2013;58(2):576-588.
4.SunL,LiH,ChenJ,IwasakiY,KubotaT,MatsuokaM,ShenA,ChenQ,XuY*.PIASymediateshypoxia-inducedtranscriptionalrepressionofSIRT1geneandepithelial-to-mesenchymaltransitionbyhypoxiainovariancancercells.JCellSci.2013September1;126(17):3939-47.
5.FangF1,ChenD,YuL,DaiX,YangY,TianW,ChengX,XuH,WengX,FangM,ZhouJ,GaoY,ChenQ,XuY*.ProinflammatorystimuliengageBrahmarelatedgene1andBrahmainendothelialinjury.CircRes.2013Sep27;113(8):986-96
6.YangY,ChengX,TianW,ZhouB,WuX,XuH,FangF,FangM,XuY*.MRTF-Asteersanepigeneticcomplextoactivateendothelin-inducedpro-inflammatorytranscriptioninvascularsmoothmusclecells.NucleicAcidsRes.2014Dec1;42(16):10460-72
7.TianW,HaoC,FanZ,WengX,QinH,WuX,FangM,ChenQ,ShenA,XuY*.MyocardinrelatedtranscriptionfactorAprogramsepigeneticactivationofhepaticstellatecells.JHepatol.2014Aug7.
8.YuL,WengX,LiangP,DaiX,WuX,XuH,FangM,FangF,XuY*.MRTF-AmediatesLPS-inducedpro-inflammatorytranscriptionbyinteractingwiththeCOMPASScomplex.JCellSci.2014Sep4.
9.YuL,YangG,WengX,LiangP,LiL,LiJ,FanZ,TianW,WuX,XuH,FangM,JiY,LiY,ChenQ,XuY*.HistoneMethyltransferaseSET1MediatesAngiotensinII-InducedEndothelin-1TranscriptionandCardiacHypertrophyinMice.ArteriosclerThrombVascBiol.2015May;35(5):1207-17.
10.WengX,YuL,LiangP,LiL,DaiX,ZhouB,WuX,XuH,FangM,ChenQ,XuY*.AcrosstalkbetweenchromatinremodelingandhistoneH3K4methyltransferasecomplexesinendothelialcellsregulatesangiotensinII-inducedcardiachypertrophy.JMolCellCardiol.2015May;82:48-58.
11.ChenD,YangY,ChengX,FangF,XuG,YuanZ,XiaJ,KongH,XieW,WangH,FangM,GaoY,XuY*.Megakaryocyticleukemia1directsahistoneH3lysine4methyltransferasecomplextoregulatehypoxicpulmonaryhypertension.Hypertension.2015Apr;65(4):821-33.
12.WengX,YuL,LiangP,ChenD,ChengX,YangY,LiL,ZhangT,ZhouB,WuX,XuH,FangM,GaoY,ChenQ,XuY*.EndothelialMRTF-AmediatesangiotensinIIinducedcardiachypertrophy.JMolCellCardiol.2015Mar;80:23-33.doi:10.1016/j.yjmcc.2014.11.009.
13.XuH,WuX,QinH,TianW,ChenJ,SunL,FangM,XuY*.Myocardin-RelatedTranscriptionFactorAEpigeneticallyRegulatesRenalFibrosisinDiabeticNephropathy.JAmSocNephrol.2015Jul;26(7):1648-60.
14.TianW,HaoC,FanZ,WengX,QinH,WuX,FangM,ChenQ,ShenA,XuY*.MyocardinrelatedtranscriptionfactorAprogramsepigeneticactivationofhepaticstellatecells.JHepatol.2015Jan;62(1):165-74.
15.FangMM,FanZW,TianWF,ZhaoYH,LiP,XuHH,ZhouBS,ZhangLP,WuXY,XuY*:HDAC4mediatesIFN-induceddisruptionofenergyexpenditure-relatedgeneexpressionbyrepressingSIRT1transcriptioninskeletalmusclecells.BBA-GeneRegulMech.2016Feb2;1859(2):294-305.
16.TianWF,FanZW,LiJF,HaoCZ,LiM,XuHH,WuXY,ZhouBS,ZhangLP,FangMM,XuY*:Myocardin-relatedtranscriptionfactorA(MRTF-A)playsanessentialroleinhepaticstellatecellactivationbyepigeneticallymodulatingTGF-βsignaling.IntJBiochemCellBiol.2016Feb;71(2):35-43.
17.FanZW,KongXC,XiaJ,WuXY,LiH,XuHH,FangMM,XuY*:TheargininemethyltransferasePRMT5regulatesCIITA-dependentMHCIItranscription.BBA-GeneRegulMech.2016May2;1859(5):687-96.
18.ZhouBS,ZengS,LiLY,FanZW,TianWF,LiM,XuHH,WuXY,FangMM,XuY*:AngiogenicfactorwithGpatchandFHAdomains1(Aggf1)regulatesliverfibrosisbymodulatingTGF-signaling.BBA-MolBasisDis.2016June2;1862(6):1203-13.
18.SunLN,FanZWChenJL,TianWF,LiM,XuHH,WuXY,ShaoJ,BianYY,FangMM,XuY*:TranscriptionalrepressionofSIRT1byproteininhibitorofactivatedSTAT4(PIAS4)inhepaticstellatecellscontributestoliverfibrosis.SciRep.2016Jun21;6:28432.
19.SunLN,FanZW,ChenJL,TianWF,LiM,XuHH,WuXY,FangMM,XiaJ,XuY*:ProteininhibitorofactivatedSTAT4(PIAS4)regulatespro-inflammatorytranscriptioninhepatocytebyrepressingSIRT1.Oncotarget.2016July12;7(28):42892-903.
20.XuHH,FanZW,TianWF,XuY*:ProteininhibitorofactivatedSTAT4(PIAS4)regulatesliverfibrosisthroughmodulatingSMAD3activity.JBiomedRes.Dec1;30(6):496-501.
21.ZengS,YangYY,ChengX,ZhouBS,LiP,ZhaoYH,KongXC,XuY*:HIC1epigeneticallyrepressesCIITAtranscriptioninBlymphocytes.BBA-GeneRegulMech.Dec2;1859(12):1841-9.
22.FanZ,LiL,LiM1,ZhangX,HaoC,YuL,ZengS,XuH,FangM,ShenA,JenuweinT,XuY*.ThehistonemethyltransferaseSuv39h2contributestononalcoholicsteatohepatitisinmice.Hepatology.2017;65(6):1904-1919.
23.FanZ,LiZ,YangY,LiuS,GuoJ,XuY*.HIF-1αcoordinatesepigeneticactivationofSIAH1inhepatocytesinresponsetonutritionalstress.BiochimBiophysActaGeneRegulMech.2017;1860(10):1037-1046.
24.YuL,FangF,DaiX,XuH,QiX,FangM,XuY*.MKL1definestheH3K4Me3landscapeforNF-κBdependentinflammatoryresponse.SciRep.2017;7(1):191.
SongM,FangF,DaiX,YuL,FangM,XuY*.MKLisanepigeneticmediatorofTNF-α-inducedproinflammatorytranscriptioninmacrophagesbyinteractingwithASH2.FEBSLett.2017;591(6):934-945.
25.YangG,ZhangX,WengX,LiangP,DaiX,ZengS,XuH,HuanH,FangM,LiY,XuD,XuY*.SUV39H1mediatedSIRT1trans-repressioncontributestocardiacischemia-reperfusioninjury.BasicResCardiol.2017;112(3):22.
26.LimingY,GuangY,XinjianZ,PengW,XinyuW,YuyuY,ZilongL,MingmingF,XuY*,AijunS*,JunboG*.MegakaryocyticLeukemia1(MKL1)BridgesEpigeneticActivationofNADPHOxidaseinMacrophagestoCardiacIschemia-ReperfusionInjury.Circulation.2018;
27.ZhangX,LiuS,WengX,ZengS,YuL,GuoJ,XuY*.Brg1deficiencyinvascularendothelialcellsblocksneutrophilrecruitmentandamelioratescardiacischemia-reperfusioninjuryinmice.IntJCardiol.2018Oct15;269:250-258.
28.LiZ,ChenB,DongW,XuW,SongM,FangM,GuoJ,XuY*.EpigeneticactivationofPERPtranscriptionbyMKL1contributestoROS-inducedapoptosisinskeletalmusclecells.BiochimBiophysActaGeneRegulMech.2018Jul27.pii:S1874-9399(18)30177-9.
29.LiZ,ZhangX,LiuS,ZengS,YuL,YangG,GuoJ,XuY*.BRG1regulatesNOXgenetranscriptioninendothelialcellsandcontributestocardiacischemia-reperfusioninjury.BiochimBiophysActaMolBasisDis.2018Oct;1864(10):3477-3486.
30.ChenB,LiZ,FengY,WuX,XuY*.Myocardin-relatedtranscriptionfactorA(MRTF-A)mediatesdoxorubicin-inducedPERPtranscriptionincoloncancercells.BiochemBiophysResCommun.2018Sep10;503(3):1732-1739.
31.LiN,KongM,ZengS,XuZ,LiM,HongW,ChuX,SunX,ZhuM,XuY*.ThechromatinremodelingproteinBRG1regulatesAPAP-inducedliverinjurybymodulatingCYP3A11transcriptioninhepatocyte.BiochimBiophysActaMolBasisDis.2018Oct;1864(10):3487-3495.
32.ShaoJ,WengX,ZhuoL,YuL,LiZ,ShenK,XuW,FangM,XuY*.AngiotensinIIinducedCSF1transcriptionismediatedbyacrosstalkbetweendifferentepigeneticfactorsinvascularendothelialcells.BiochimBiophysActaGeneRegulMech.2018Oct12;1862(1):1-11.
33.ZhangX,LiuS,WengX,WuT,YuL,XuY*,GuoJ.Brg1trans-activatesendothelium-derivedcolonystimulatingfactortopromotecalciumchlorideinducedabdominalaorticaneurysminmice.JMolCellCardiol.2018Oct16;125:6-17.
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