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个人简介

季勇,南京医科大学副校长,南京医科大学教学名师。 1991年毕业于南京医学院,获临床医学学士学位,1998年毕业于南京医科大学,获药理学博士学位。2001-2002年在法国国家医学科学院做博士后研究,2002-2004年在英国伦敦大学国王学院任研究助理。2004年回国后被南京医科大学聘为教授。 先后主持科技部973前期研究专项1项、国家自然科学基金重点项目2项、国家自然科学基金面上项目4项、省部级科学基金项目5项、学术骨干参与“973”计划项目1项、江苏省教育厅教改重点项目1项。在ProcNatlAcadSciUSA,AntioxidRedoxSignal,CardiovascRes,JMolCellCardiol等SCI收录杂志上发表学术论文50余篇。

研究领域

心血管疾病的发病机制及药物防治研究

近期论文

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近五年代表性论文(*为通讯作者)、专利 1.LinZ,AltafN,LiC,ChenM,PanL,WangD,XieL,ZhengY,FuH,HanY,JiY*.Hydrogensulfideattenuatesoxidativestress-inducedNLRP3inflammasomeactivationviaS-sulfhydratingc-JunatCys269inmacrophages.BiochimBiophysActaMolBasisDis.2018;1864(9PtB):2890-2900. 2.CuetoR,ZhangL,ShanHM,HuangX,LiX,LiYF,LopezJ,YangWY,LavalleeM,YuC,JiY*,YangX,WangH*.Identificationofhomocysteine-suppressivemitochondrialETCcomplexgenesandtissueexpressionprofile-Novelhypothesisestablishment.RedoxBiol.2018;17:70-88. 3.WangX,HuangY,JiY*.Spotlightonsmallmoleculesincardiovasculardiseases.BrJPharmacol.2018;175(8):1111-1113. 4.WangW,WangD,KongC,LiS,XieL,LinZ,ZhengY,ZhouJ,HanY*,JiY*.eNOSS-nitrosylationmediatedOxLDL-inducedendothelialdysfunctionviaincreasingtheinteractionofeNOSwithβ-catenin.BiochimBiophysActaMolBasisDis.2018Feb20.pii:S0925-4439(18)30066-8. 5.MaoY,WangL,ZhuY,LiuY,DaiH,ZhouJ,GengD*,WangL*,JiY*.Tensionforce-inducedboneformationinorthodontictoothmovementviamodulationoftheGSK-3β/β-cateninsignalingpathway.JMolHistol.2018;49(1):75-84. 6.WuJ,XingC,ZhangL,MaoH,ChenX,LiangM,WangF,RenH,CuiH,JiangA,WangZ,ZouM*,JiY*.Autophagypromotesfibrosisandapoptosisintheperitoneumduringlong-termperitonealdialysis.JCellMolMed.2018;22(2):1190-1201. 7.LiuW*,Ruiz-VelascoA,WangS,KhanS,ZiM,JungmannA,DoloresCamacho-MuñozM,GuoJ,DuG,XieL,OceandyD,NicolaouA,GalliG,MüllerOJ,CartwrightEJ,JiY*,WangX*.Metabolicstress-inducedcardiomyopathyiscausedbymitochondrialdysfunctionduetoattenuatedErk5signaling.NatCommun.2017;8(1):494. 8.WangJ,WangW,LiS,HanY,ZhangP,MengG,XiaoY,XieL,WangX,ShaJ,ChenQ,MoorePK,WangR,XiangW*,JiY*.Hydrogensulfideasapotentialtargetinpreventingspermatogenicfailureandtesticulardysfunction.AntioxidRedoxSignal.2018;28(16):1447-1462. 9.MengG,LiuJ,LiuS,SongQ,LiuL,XieL,HanY,JiY*.HydrogensulfidepretreatmentimprovesmitochondrialfunctioninmyocardialhypertrophyviaaSIRT3dependentmanner.BrJPharmacol.2018;175(8):1126-1145. 10.MengG,ZhaoS,XieL,HanY,JiY*.ProteinS-sulfhydrationbyhydrogensulfideincardiovascularsystem.BrJPharmacol.2018;175(8):1146-1156. 11.ChenY,MengG,BaiW,MaY,XieL,AltafN,QianY,HanY*,JiY*.Aliskirenprotectsagainstmyocardialischaemia-reperfusioninjuryviaanendothelialnitricoxidesynthasedependentmanner.ClinExpPharmacolPhysiol.2017;44(2):266-274. 12.Chun-MeiJ,WuC,Guo-LiangM,YueG,NingC*,JiY*.Productionofendogenoushydrogensulfideinhumangingivaltissue.ArchOralBiol.2017;74:108-113. 13.ChaoML,GuoJ,ChengWL,ZhuXY,SheZG,HuangZ,JiY*,LiH*.LossofCaspase-ActivatedDNaseProtectsAgainstAtherosclerosisinApolipoproteinE-DeficientMice.JAmHeartAssoc.2016;5(12). 14.YangJ,FangP,YuD,ZhangL,ZhangD,JiangX,YangWY,BottiglieriT,KunapuliSP,YuJ,ChoiET,JiY*,YangX,WangH*.ChronicKidneyDiseaseInducesInflammatoryCD40+MonocyteDifferentiationviaHomocysteineElevationandDNAHypomethylation.CircRes.2016;119(11):1226-1241. 15.XieL,GuY,WenM,ZhaoS,WangW,MaY,MengG,HanY,WangY,LiuG,MoorePK,WangX,WangH,ZhangZ,YuY,FerroA,HuangZ*,JiY*.HydrogenSulfideInducesKeap1S-sulfhydrationandSuppressesDiabetes-AcceleratedAtherosclerosisviaNrf2Activation.Diabetes.2016;65(10):3171-3184. 16.MengG,XiaoY,MaY,TangX,XieL,LiuJ,GuY,YuY,ParkCM,XianM,WangX,FerroA,WangR,MoorePK,ZhangZ,WangH,HanY*,JiY*.HydrogenSulfideRegulatesKrüppel-LikeFactor5TranscriptionActivityviaSpecificityProtein1S-SulfhydrationatCys664toPreventMyocardialHypertrophy.JAmHeartAssoc.2016;5(9).pii:e004160. 17.XiH,ZhangY,XuY,YangWY,JiangX,ShaX,ChengX,WangJ,QinX,YuJ,JiY*,YangX,WangH*.Caspase-1InflammasomeActivationMediatesHomocysteine-InducedPyrop-ApoptosisinEndothelialCells.CircRes.2016;118(10):1525-1539. 18.TangY,LiS,ZhangP,ZhuJ,MengG,XieL,YuY,JiY*,HanY*.SoyIsoflavoneProtectsMyocardialIschemia/ReperfusionInjurythroughIncreasingEndothelialNitricOxideSynthaseandDecreasingOxidativeStressinOvariectomizedRats.OxidMedCellLongev.2016;2016:5057405. 19.GuY,TangX,XieL,MengG*,JiY*.Aliskirenimprovesendothelium-dependentrelaxationofthoracicaortabyactivatingPI3K/Akt/eNOSsignalpathwayinSHR.ClinExpPharmacolPhysiol.2016;43(4):450-458. 20.XieL,FengH,LiS,MengG,LiuS,TangX,MaY,HanY,XiaoY,GuY,ShaoY,ParkCM,XianM,HuangY,FerroA,WangR,MoorePK,WangH*,JiY*.SIRT3MediatestheAntioxidantEffectofHydrogenSulfideinEndothelialCells.AntioxidRedoxSignal.2016;24(6):329-343. 21.MengG,ZhuJ,XiaoY,HuangZ,ZhangY,TangX,XieL,ChenY,ShaoY,FerroA,WangR,MoorePK,JiY*.HydrogenSulfideDonorGYY4137ProtectsagainstMyocardialFibrosis.OxidMedCellLongev.2015;2015:691070. 22.MengG,WangJ,XiaoY,BaiW,XieL,ShanL,MoorePK,JiY*.GYY4137protectsagainstmyocardialischemiaandreperfusioninjurybyattenuatingoxidativestressandapoptosisinrats.JBiomedRes.2015;29(3):203-13. 23.ChengWL#,WangPX,WangT,ZhangY,DuC,LiH*,JiY*.RegulatorofG-proteinsignalling5protectsagainstatherosclerosisinapolipoproteinE-deficientmice.BrJPharmacol.2015;172(23):5676-5689. 24.MengG,MaY,XieL,FerroA,JiY*.Emergingroleofhydrogensulfideinhypertensionandrelatedcardiovasculardiseases.BrJPharmacol.2015;172(23):5501-5511. 25.ZhangW,HanY,MengG,BaiW,XieL,LuH,ShaoY,WeiL,PanS,ZhouS,ChenQ,FerroA*,JiY*.Directrenininhibitionwithaliskirenprotectsagainstmyocardialischemia/reperfusioninjurybyactivatingnitricoxidesynthasesignalinginspontaneouslyhypertensiverats.JAmHeartAssoc.2014;3(1):e000606. 26.ShanLY#,LiJZ#,ZuLY,NiuCG,FerroA,ZhangYD,ZhengLM*,JiY*.Platelet-derivedmicroparticlesareimplicatedinremoteischemiaconditioninginaratmodelofcerebralinfarction.CNSNeurosciTher.2013;19(12):917-925. 27.LiuZ,HanY,LiL,LuH,MengG,LiX,ShirhanM,PehMT,XieL,ZhouS,WangX,ChenQ,DaiW,TanCH,PanS,MoorePK,JiY*.Thehydrogensulfidedonor,GYY4137,exhibitsanti-atheroscleroticactivityinhighfatfedapolipoproteinE(-/-)mice.BrJPharmacol.2013;169(8):1795-809. 28.YuSS,CaiY,YeJT,PiRB,ChenSR,LiuPQ*,ShenXY*,JiY*.Sirtuin6protectscardiomyocytesfromhypertrophyinvitroviainhibitionofNF-κB-dependenttranscriptionalactivity.BrJPharmacol.2013;168(1):117-128. 29.中国发明专利,ZL201310694659.7,季勇,王婧,孟国梁,肖玉娇,谢利平,韩艺,李双越。硫化氢及其供体在改善精子质量及功能中的应用。 30.中国发明专利,201711246138.X,季勇,张艳,李尘,陈梅,韩艺,谢利平。三联组氨酸核苷结合蛋白的应用。

学术兼职

学术兼职:英国药理学报(BritishJournalofPharmacology)副主编 英国药理学会委员 中国病理生理学会动脉粥样硬化专业委员会副主任委员 中国药理学会心血管药理专业委员会常委 中国生物化学与分子生物学会脂质与脂蛋白专业委员会委员兼青年委员会副主任委员 中国病理生理学会心血管青年专业委员会副主任委员 国际动脉粥样硬化学会中国分会常务理事

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