当前位置: X-MOL首页全球导师 国内导师 › 杨帆

个人简介

教育与工作经历 1986年9月-1990年7月,西北大学化学系 学士学位 1990年9月-1996年7月,中国科学院兰州化学物理研究所 硕士学位、博士学位 1996年11月-1999年5月,中国药科大学药学院博士后 2000年8月-2006年11月,华东师范大学化学系副教授 2006年12月-今,华东师范大学化学与分子工程学院,上海分子治疗与新药创制工程技术研究中心 教授 2008年11月-12月,法国加香高师邀请教授 多年来从事功能有机分子合成与应用领域的研究工作:生物活性天然甾体和萜类化合物为母核的结构改造及其在代谢性疾病治疗、抗菌、抗肿瘤等小分子药物发现中的应用;甾体药物绿色制造工艺研究。2001年入选“上海市科技启明星”计划,2015年获江苏省“淮上英才计划”创新创业领军人才称号,2016年获近年来主持或参与国家自然科学基金、“十二五”重大新药创制国家科技重大专项、国家科技支撑项目、上海市科委基础研究重点、国际合作等项目十余项;同时,与多家企业开展科技合作,完成、承担企业项目十余项。发表研究论文80余篇;申请专利57项,其中31项已授权;8项成果通过省级鉴定。

研究领域

小分子药物发现;甾体药物绿色制造

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Sheng Wang, Lei Xu, Yu-Ting Lu, Yu-Fei Liu, Bing Han, Ting Liu, Jie Tang, Jia Li, Jiangping Wu, Jing-Ya Li, Li-Fang Yu, Fan Yang, Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet B-cells from apoptosis, Eur. J. Med. Chem., 2017, 130, 195-208 Jing Wang, Teng Yang, Huang Chen, Yun-Nan Xu, Li-Fang Yu, Ting Liu, Jie Tang, Zhengfang Yi, Cai-Guang Yang, Wei Xue, Fan Yang, The synthesis and antistaphylococcal activity of 9,13-disubstituted berberine derivatives, Eur. J. Med. Chem., 2017, 127, 424-433 Sun, Hao; Shi, Min; Zhang, Wei; Zheng, Yue-Ming; Xu, Yazhou; Shi, Jun-Jie; Liu, Ting; Gunosewoyo, Hendra; Pang, Tao; Gao, Zhao-Bing; Yang, Fan; Tang, Jie; Yu, Li-Fang, Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Anti-Nociceptive Efficacy, J. Med. Chem., 2016, 59, 6329-6343 Shi-Wei Mao, Huang Chen, Li-Fang Yu, Fang Lv, Ya-Jing Xing, Ting Liu, JiaXie, Jie Tang, Zhengfang Yi, Fan Yang,Novel 3,4-seco bile acid diamides as selective anticancer proliferation and migration agents, Eur. J. Med. Chem., 2016, 122, 574-583 Jiefeng Zhang, JiakunQiu, Chunmei Xiao, Lifang Yu, Fan Yang, Jie Tang, Tandem demethylation/annulation/oxidation of 2,3-Bis(2-methoxyphenyl)-3- oxopropanals for One-Pot Construction of Coumestans, Eur. J. Org. Chem., 2016, 3380-3385 Sheng Wang, Chao Zhao, Ting Liu, Lifang Yu, Fan Yang, Jie Tang, Efficient construction of 3-arylquinolin-4(1H)-ones via in situ Meinwald rearrangement/intramolecular reductive cyclization of 2’-nitrochalcone epoxides, Tetrahedron, 2016, 72(44),7025-7031 Shi-Wei Mao, Lin Shuai, Hai-Bing He, Na Pan, Li-Xin Gao, Li-Fang Yu, Jia Li, Jing-Ya Li, Fan Yang, Synthesis and biological evaluation of novel 2,3-pyrazole ring-substituted-4,4-dimethyl lithocholic acid derivatives as selective protein tyrosine phosphatase 1B (PTP1B) inhibitors with cellular efficacy, RSC Adv., 2015, 5, 106551-106560 Ben-ren Liao, Hai-bing He, Ling-ling Yang, Li-Xin Gao, Liang Chang, Jie Tang, Jing-Ya Li, Jia Li, Fan Yang, Synthesis and structure-activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-diphenyl-1,3,4-oxadiazoles, Eur. J. Med. Chem. 2014, 83, 15-25 Libo Ruan,Min Shi,Nian Li, Xu Ding,FanYang,Jie Tang, Practical Approach for Preparation of Unsymmetric Benzils from ?-Ketoaldehydes, Org. Lett., 2014, 16, 733-735 Libo Ruan, Min Shi, Shiwei Mao, Lifang Yu, Fan Yang, Jie Tang, An efficient approach to construct 2-arylbenzo[b]furans from 2-methoxychalcone epoxides, Tetrahedron, 2014, 70, 1065-1070 Yantao Qi, XiuhuaWang, Hong Chen, Jie Tang,Fan Yang, Pingang He,Luminescent Multiruthenium Metallocyclodextrins: Synthesis, Fluorescence and Electrochemiluminescence Properties Based on Host-Guest Recognition, Inorganic Chemistry Communications, 2014, 40, 11-14 Jia Jin, Yifan Shan, Fan Yang, Hua Lai, Hongwei Tan, Xiaofeng Liu, Jie Tang, Qiang Fang, Organic photosensitizers with N-carboxymethyl pyridinium acceptor/anchoring group for dye-sensitized solar cells, Synthetic Metals, 2012, 162, 2222-2227 Hai-Bing He, Li-Xin Gao, Qi-Feng Deng, Wei-Ping Ma, Chun-Lan Tang, Wen-Wei Qiu, Jie Tang, Jing-Ya Li, Jia Li, Fan Yang, Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B, Bioorg. Med. Chem. Lett., 2012, 22, 7237-7242, DOI: 10.1016/j.bmcl.2012.09.040 Yifan Shan, Jie Tang, Hua Lai, Hongwei Tan, Xiaofeng Liu, Fan Yang and Qiang Fang, Ethoxy-substituted Oligo-phenylenevinylene-Bridged Organic Dyes for Efficient Dye-Sensitized Solar Cells, Chin. J. Chem. 2012, 30, 1497-1503, DOI: 10.1002/cjoc.201200091(Most Accessed in 7/2012, No 1)4. Hai-Bing He, Li-Xin Gao, Yue-Yang Zhou, Ting Liu, Jie Tang, Xue-Ping Gong, Wen-Wei Qiu, Jing-Ya Li, Jia Li, and Fan Yang, Design, Synthesis and Biological Activity Evaluation of 2,5-Diphenyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Fructose-1,6-bisphosphatase, Heterocycles, 2012, 85(11), 2693-2712, DOI: 10.3987/COM-12-12565 Hui Li, Jin-Ping Wang, Fan Yang, Ting Liu, Wen-Wei Qiu, Jing-Ya Li, Jia Li, and Jie Tang, Design, synthesis and biological activity evaluation of 2-mercapto-4(3H)-quinazolinone derivatives as novel inhibitors of protein tyrosine phosphatase 1B, Hetrocycles, 2012, 85(8), 1897-1911 Hui Li, Hui Zou, Lixin Gao, Ting Liu, Fan Yang, Jingya Li, Jia Li, Wen-Wei Qiu, and Jie Tang, Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B, Heterocycles, 2012, 85(5), 1117-1139 Xian Wu, Zhenxi Li, Zhengfeng Yang, Chunbing Zheng, Ji Jing, Yihua Chen, Xiyun Ye, Xiaoyuan Lian, Weiwei Qiu, Fan Yang, Jie Tang, Jianru Xiao, Mingyao Liu, Jian Luo, CADPE suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of MAPK/AP-1 and Ca2+-NFAT signaling pathways, J. Bone Miner. Res. (IF 7.1, the best journal in Bone field), 2012, 27(6), 1298-2308 DOI: 10.1002/jbmr.1576 Jun Xu, Zhenxi Li, Jian Luo, Fan Yang, Ting Liu, Mingyao Liu, Wen-Wei Qiu, Jie Tang, Synthesis and Biological Evaluation of Heterocyclic Ring substituted Betulinic Acid Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption, J. Med. Chem., 2012, 55(7), 3122-3134, Hui Li, Qing Zhou, Pierre Audebert, Fabien Miomandre, Clémence Allain, Fan Yang, Jie Tang, New conducting polymers functionalized with redoxactive tetrazines, J. Electroanal. Chem., 2012, 668, 26-29. Yifan Shan, Jie Tang, Hua Lai, Hongwei Tan, Fan Yang, Qiang Fang, Pierre Audebert, Adam Pron, Pyridinium hemicyanine dyes with carboxylate anion anchoring group:A novel acceptor in application of dye-sensitized solar cells, Tetrahedron Lett., 2012, 53, 1341-1344 Wanrong Luo, Qiuchao Mu, Wenwei Qiu, Ting Liu, Fan Yang, Xiaofeng Liu, Jie Tang, A Novel Friedlander-Type Synthesis Of 3-Aryl Quinolines From 3-Oxo-2,3-Diaryl-Propionaldehydes, Tetrahedron, 2011, 67, 7090-7095 Wanrong Luo, Zhichao Yu, Wenwei Qiu, Fan Yang, Xiaofeng Liu, and Jie Tang, One-pot production of chiral α,β-epoxy ketones from benzaldehydes and acetophenones by recyclable poly(amino acid) catalysis, Tetrahedron, 2011, 67, 5289-5292 Wang haiming, Wang Jinping, Qiu Wenwei, Yang Fan, Liu Xiaofeng, Tang Jie, Highly efficient palladacycle/Dihydroimidazolium chloride system for the Suzuki-Miyaura cross-coupling of aryl halides (I, Br, Cl) with arylboronic acids, Chin. J. Chem., 2010, 28, 2416-2420 Xiuhua Wang, Hao Fan, Fan Zhang, Yantao Qi, Wenwei Qiu, Fan Yang, Jie Tang, and Pingang He, Synthesis Of A bCyclodextrin Derivate And Its Molecular Recognition Behavior On Modified Glassy Carbon Electrode By Diazotization, Tetrahedron, 2010, 66, 7815-7820 Chun Li, Wenwei Qiu, Zhengfeng Yang, Jian Luo, Fan Yang, Mingyao Liu, Juan Xie, Jie Tang, Stereoselective synthesis of some methyl substituted steroid hormones and their in vitro cytotoxic activity against human gastric cancer cell line MGC-803, Steroids, 2010, 75(12), 859-69 Wen-Wei Qiu, Qiang Shen, Fan Yang, Bo Wang, Hui Zou, Jing-Ya Li, Jia Li, Jie Tang, Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1, Bioorganic & Medicinal Chemistry Letters 2009, 19, 6618–6622 Wenwei Qiu, Linmei He, Qi Chen, Wanrong Luo, Zhichao Yu, Fan Yang, Jie Tang, Imidazolium-Modified Poly(L-Leucine) Catalyst: An Efficient and Recoverable Catalyst for Juliá-Colonna Reactions, Tetrahedron Lett. 2009, 50(37) , 5225-5227 Bo Wang, Fan Yang, Yi-Fan Shan, Wen-Wei Qiu, Jie Tang, Highly efficient synthesis of capsaicin analogues by condensation of vanillylamine and acyl chlorides in a biphase H2O/CHCl3 system, Tetrahedron, 2009, 65(27), 5409-5412 GONG, Yong-Hua, QIU, WenWei, YANG, Fan, AUDEBERT, Pierre, CLAVIER, Gilles, MIOMANDRE, Fabien, TANG, Jie, Pyridinium Conjugated Ferrocenes with Thien and Bithien Bridges: Synthesis and Electrochemical Properties, Chin. J. Chem. 2009, 27, 1515-1522 Xiuling Xu, Wenwei Qiu, Qing Zhou, Pierre Audebert, Jie Tang, Fan Yang, Zhenrong Sun, Nonlinear Optical Absorption Properties of Two ultisubstituted p-Dimethylaminophenyl-ethenyl Pyridiniums, J. Phy. Chem. B, 2008, 112 (16) , 4913-4917 Yong-Hua Gong, Pierre Audebert, Fan Yang, Fabien Miomandre, Xiao-Chun Lian, Jie Tang, New pyridinium conjugated ferrocenes: Synthesis and electrochemical properties, J. Electroanal. Chem., 2007, 606(1), 8-16 Fan Yang, Lin-Mei He, Hua Yi, Gang Zou, Jie Tang, Ming-Yuan He, An efficient silica-grafted poly-(L)-leucine catalyst for asymmetric epoxidation of a, b-unsaturated ketone, J. Mol. Catal. A: Chemical, 2007, 273(1-2), 1-4 Fan Yang, Xiu-Ling Xu, Yong-Hua Gong, Wen-Wei Qiu, Zhen-Rong Sun, Jin-Wei Zhou, Pierre Audebert, Jie Tang, Synthesis and Nonlinear Optical Absorption of Two New Conjugated Ferrocene-Bridge-Pyridinium Compounds, Tetrahedron, 2007, 63(37), 9188-9194 Hai-Ming Wang, Peng Cui, Gang Zou, Fan Yang, Jie Tang, Temperature-controlled highly selective dimerization of a-methylstyrene catalyzed by Bronsted acidic ionic liquid under solvent-free conditions, Tetrahedron, 2006, 62(17), 3985-3988

学术兼职

英国皇家化学会“Green Chemistry”,以及“Journal of Heterocyclic Chemistry”、“Organic & Biomolecular Chemistry”等期刊特约审稿人

推荐链接
down
wechat
bug