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个人简介

研究工作经历: 08/2018至今南方医科大学,药学院,教授 12/2012-07/2018南方医科大学,药学院,副教授 10/2009-09/2012美国国立卫生研究院,过敏原与传染病研究所,博士后 05/2009-09/2009美国弗吉尼亚大学,药学院,博士后 07/2007-05/2009南方医科大学,药学院,讲师 学习经历: 09/2004-07/2007中国科学院,昆明动物研究所,博士 09/2001-07/2004南京农业大学,动物医学院,硕士 09/1997-07/2001湖北农学院,动物科学系,学士 承担课程: 《药理学》,《微生物与生化药学院》 科研课题: 1.国家自然科学基金国际(地区)合作与交流项目,31911530077,花姬蛙皮肤小分子丝氨酸蛋白酶抑制剂的结构与功能研究,2019/01-2020/12,10万元,在研,主持; 2.国家自然科学基金国际(地区)合作与研究项目,31861143050,埃及蝎毒新型抗肿瘤肽的分子鉴定和研发,2019/01-2021/12,170万元,在研,主持; 3.国家自然科学基金面上项目,31772476,花姬蛙皮肤潜在药用多肽的结构与功能研究,2018/01-2021/12,70万元,在研,主持; 4.国家自然科学基金面上项目,31370782,印鼠客蚤FS50肽抑制Nav1.5钠通道的结构基础和作用机制,2014/01-2017/12,80万元,结题,主持; 5.国家自然科学金,30800185,蛴螬活血化瘀的分子机制研究,2009/01-2011/12,20万元,结题,主持; 6.南方医科大学杰青培养计划项目,蛋白质与多肽生物化学,2014/01-2016/12,45万元,结题,主持; 7.广州市产学研协同创新重大专项产业技术研究项目,重组人透明质酸酶的细胞株开发与工艺优化研究、2016/01-2018/12,60万元,结题,共同主持; 获奖情况: 1.云南省科学技术奖自然科学一等奖(获奖人排名:赖仞、杨世隆、徐学清、杨海龙、张治业、安舒、李东升),云南省政府,2018 2.霍英东青年教师奖(三等奖),霍英东教育基金会,2010; 3.优秀科技论文特等奖(获奖人排名:徐学清、杨海龙、马东莹、武静、赖仞),云南省科学技术协会,2010; 4云南省科学技术奖突出贡献类自然科学一等奖(获奖人排名:赖仞、张云、李建许、张亚平、郑永唐、徐学清、杨海龙、李文辉),云南省政府,2008; 5.先进工作者荣誉称号;南方医科大学,2008; 6.院长奖优秀奖,中国科学院,2007;

研究领域

研究方向: 1.吸血节肢动物唾液腺蛋白的结构功能关系研究 2.动物毒素活性多肽组分的开发与利用

近期论文

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主要论著: 1.DengZ,ChaiJ,ZengQ,ZhangB,YeT,ChenX,XuX.Theanticancerpropertiesandmechanismofactionoftablysin-15,theRGD-containingdisintegrin,inbreastcancercells.IntJBiolMacromol.2019,129:1155-1167.(IF:4.08)0141--8130 2.ZengB,ChaiJ,DengZ,YeT,ChenW,LiD,ChenX,ChenM,XuX.FunctionalCharacterizationofaNovelLipopolysaccharide-BindingAntimicrobialandAnti-InflammatoryPeptideinVitroandinVivo.JMedChem.2018,61(23):10709-10723(IF:6.259) 3.ZhangB,DengZ,ZengB,YangS,ChenX,XuX#,WuJ#.In-vitroeffectsoftheFS50proteinfromsalivaryglandsofXenopsyllacheopisonvoltage-gatedsodiumchannelactivityandmotilityofMDA-MB-231humanbreastcancercells.AnticancerDrugs.2018,29(9):880-889(IF:1.869) 4.XuX#,ZhangB,YangS,AnS,RibeiroJM,AndersenJF#.StructureandFunctionofFS50,asalivaryproteinfromthefleaXenopsyllacheopisthatblocksthesodiumchannelNaV1.5.SciRep.2016,6:36574(IF:5.288) 5.XuX#,LiuWJ,LiWZ,LiuSW#.AnticoagulantactivityofcrudeextractofHolotrichiadiomphalialarvae.JournalofEthnopharmacology,2016,7:28-34.(IF:2.998) 6.XuX,LaiR,TheChemistryandBiologicalActivitiesofPeptidesfromAmphibianSkinSecretions,ChemicalReviews,2015,115(4):1760-1846.(IF:45.6) 7.XuX,ChangBW,MansBJ,RibeiroJM,AndersenJF.Thestructureandligand-bindingpropertiesofthebiogenicamine-bindingproteinfromsalivaofablood-feedinginsectvectorofTrypanosomacruzi.ActaCrystallogrDBiolCrystallogr,69(Pt1):105-13.2013.(IF:12.619) 8.XuX,OliveiraF,ChangBW,CollinN,GomesR,TeixeiraC,ReynosoD,PhamVM,ElnaiemDE,KamhawiS,RibeiroJM,ValenzuelaJG,AndersenJF.Structureandfunctionofa"yellow"proteinfromsalivaofthesandflyLutzomyialongipalpisthatconfersprotectiveimmunityagainstLeishmaniamajorinfection.JBiolChem,286(37):32383-93,2011(IF:5.328) 9.XuX,FrancischettiIM,LaiR,RibeiroJM,AndersenJF.Structureofproteinhavinginhibitorydisintegrinandleukotrienescavengingfunctionscontainedinsingledomain.JBiolChem,287(14):10967-76,2012(IF:4.773) 10.MaD,XuX,AnS,LiuH,YangX,AndersenJF,WangY,TokumasuF,RibeiroJM,FrancischettiIM,LaiR.AnovelfamilyofRGD-containingdisintegrins(Tablysin-15)fromthesalivaryglandofthehorseflyTabanusyaotargetsαIIbβ3orαVβ3andinhibitsplateletaggregationandangiogenesis.ThrombosisandHaemostasis,105(6):1032-45,2011(IF:4.701) 11.XuX,YangH,MaD,WuJ,WangY,SongY,WangX,LuY,YangJ,LaiR.Towardanunderstandingofthemolecularmechanismforsuccessfulbloodfeedingbycouplingproteomicsanalysiswithpharmacologicaltestingofhorseflysalivaryglands.MolCellProteomics,7(3):582-90,2008(IF8.834) 12.LiJ,XuX,XuC,ZhouW,ZhangK,YuH,ZhangY,ZhengY,ReesHH,LaiR,YangD,WuJ.Anti-infectionpeptidomicsofamphibianskin.MolCellProteomics,6(5):882-94,2007(IF9.425) 13.LiJ,ZhangC,XuX,WangJ,YuH,LaiR,GongW.Trypsininhibitoryloopisanexcellentleadstucturetodesignserineproteaseinhibitorsandantimicrobialpeptides.TheFASEBJournal,21(10):2466-73,2007(IF7.2) 14.XuX,LiJ,LuQ,YangH,ZhangY,LaiR.Twofamiliesofantimicrobialpeptidefromwasp(Vespamagnifica)venom.Toxicon,47(2):249-53,2006(IF2.6) 15.XuX,LiJ,HanY,YangH,LiangJ,LuQ,LaiR.Twoantimicrobialpeptidesfromskinsecretionsofranagrahami.Toxicon,47(4):459-64,2006(IF2.6) 16.XuX,YangH,YuH,LiJ,LaiR.Themastoparanogenfromwasp.Peptides,27(12):3053-7,2006(IF2.6) 17.YangH,XuX,MaD,ZhangK,LaiR.AphospholipaseA1plateletactivatorfromthewaspvenomofVespamagnifica(Smith).Toxicon,51(2):289-96,2008(IF:2.46) 18.LiJ,XuX,YuH,YangH,HuangZ,LaiR.DirectantimicrobialactivitiesofPR-bombesin.LifeSciences,78(17):1953-6,2006(IF1.6) 19.MaD,WangY,YangH,WuJ,AnS,GaoL,XuX,LaiR.Anti-thrombosisrepertoireofblood-feedinghorseflysalivaryglands.MolCellProteomics.MolCellProteomics.8(9):2071-9,2009(IF:8.345) 20.MaD,LiY,DongJ,AnS,WangY,LiuC,YangX,YangH,XuX,LinD,LaiR.Purificationandcharacterizationoftwonewallergensfromthesalivaryglandsofthehorsefly,Tabanusyao.Allergy,66(1):101-9,2011(IF:6.297) 21.AnS,ChenL,WeiJF,YangX,MaD,XuX,XuX,HeS,LuJ,LaiR.PurificationandcharacterizationoftwonewallergensfromthevenomofVespamagnifica.PLoSOne,7(2):e31920,2012(IF:4.1) 22.LiJ,WuH,HongJ,XuX,YangH,WuB,WangY,ZhuJ,LaiR,JiangX,LinD,PrescottMC,ReesHH.Odorranalectinisasmallpeptidelectinwithpotentialfordrugdeliveryandtargeting.PLoSOne,.3(6):e2381,2008(IF4.41) 23.LiJ,WuJ,WangY,XuX,LiuT,LaiR,ZhuH.AsmalltrypsininhibitorfromthefrogofOdorranagrahami.Biochimie,90(9):1356-61,2008(IF3.071) 24.MaD,GaoL,AnS,SongY,WuJ,XuX,LaiR.Ahorseflysalivaantigen5-likeproteincontainingRTSmotifisanangiogenesisinhibitor.Toxicon.55(1):45-51,2010(IF2.451) 25.QiZ,PanC,LuH,ShuiY,LiL,LiX,XuX,LiuS,JiangS.ArecombinantmimeticsoftheHIV-1gp41prehairpinfusionintermediatefusedwithhumanIgGFcfragmentelicitsneutralizingantibodyresponseinthevaccinatedmice.BiochemBiophysResCommun,398(3):506-12,2010(IF:2.595) 26.HanJ,YouD,XuX,HanW,LuY,LaiR,MengQ.AnanticoagulantserineproteasefromthewaspvenomofVespamagnifica.Toxicon,51(5):914-22,2008(IF2.46) 27.CheQ,ZhouY,YangH,LiJ,XuX,LaiR.AnovelantimicrobialpeptidefromamphibianskinsecretionsofOdorranagrahami.Peptides,29(4):529-35,2008(IF2.654) 28.ChenL,LiY,LiJ,XuX,LaiR,ZouQ.AnantimicrobialpeptidewithantimicrobialactivityagainstHelicobacterpylori.Peptides,28(8):1527-31,2007(IF2.654) 29.LiJ,YuH,XuX,WangX,LiuD,LaiR.Multiplebombesin-likepeptideswithoppositefunctionsfromskinofOdorranagrahami.Genomics,89(3):413-8,2007(IF3.327) 30.WangX,SongY,LiJ,LiuH,XuX,LaiR,ZhangK.AnewfamilyofantimicrobialpeptidesfromskinsecretionsofRanapleuraden.Peptides,28(10):2069-74,2007(IF2.654) 31.LuY,LiJ,YuH,XuX,LiangJ,TianY,MaD,LinG,HuangG,LaiR.Twofamiliesofantimicrobialpeptideswithmultiplefunctionsfromskinofrufous-spottedtorrentfrog,Amolopsloloensis,Peptides,27(12):3085-91,2006(IF2.46) 32.LiJ,LiuT,XuX,WangX,WuM,YangH,LaiR.Amphibiantachykininprecursor,BiochemicalandBiophysicalResearchCommunications,350(4):983-6,2006(IF2.9) 33.LiangJ,HanY,LiJ,XuX,ReesHH,LaiR.Anovelbradykinin-peptidefromskinsecretionsofrufous-spottedtorrentfrog,Amolopsloloensis.Peptides,27(11):2683-7,2006(IF2.46) 34.YuD,ShengZ,XuX,LiJ,YangH,LiuZ,ReesHH,LaiR.Anovelantimicrobialpeptidefromsalivaryglandsofthehardtick,Ixodessinensis.Peptides,27(1):31-5,2006(IF2.46) 35.ZhouZ,YangH,XuX,WangX,LaiR.Thefirstreportofkininogenfrominvertebrates.BiochemBiophysResCommun,347(4):1099-102,2006(IF2.648) 36.AlvarengaPH,XuX,OliveiraF,ChagasAC,NascimentoCR,FrancischettiIM,JulianoMA,JulianoL,ScharfsteinJ,ValenzuelaJG,,RibeiroJM,AndersenJF,Novelfamilyofinsectsalivaryinhibitorsblockscontactpathwayactivationbybindingtopolyphosphate,heparin,anddextransulfate.ArteriosclerThrombVascBiol,2013,33(12):2759-2770 37.VeigaAB,RibeiroJM,FrancischettiIM,XuX,GuimarãesJA,AndersenJF.Examinationoftheligand-bindingandenzymaticpropertiesofabilin-bindingproteinfromthepoisonouscaterpillarLonomiaobliqua.PLoSOne.2014Jun27;9(6):e95424.

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