研究领域

Analytical/Biological/Materials and Nanoscience/Organic

Analytical Fluorescence Imaging of Protein Trafficking in Live Cells Biological Chemical Biology of Carbohydrates and Peptides Materials and Nanoscience Nano Material for Molecular Imaging in Live Cells Organic Synthetic and Biological Studies of Carbohydrates and Peptides Biomedical

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Development of efficient methods for accomplishing cysteine-free peptide and glycopeptide coupling. Gong Chen, Qian Wan, Zhongping Tan, Cindy Kan, Krishnakumar Ranganathan, Zihao Hua, and Samuel J. Danishefsky. Angew. Chem. Int. Ed. 2007, 46, 7383-7386. Mature homogeneous erythropoietin building blocks by chemical synthesis: the EPO 114-166 glycopeptide domain presenting its O-linked glycophorin. Jiehao Chen, Gong Chen, Bin Wu, Qian Wan, Zhongping Tan, Zihao Hua, and Samuel J. Danishefsky. Tetrahedron Lett. 2006, 47, 8013-8016. Mature homogeneous erythropoietin building blocks by chemical synthesis: the EPO 22-37 glycopeptide domain presenting the fully N-linked dodecasaccharide. Bin Wu, Zhongping Tan, Gong Chen, Jiehao Chen, Zihao Hua, Qian Wan, Krishnakumar Ranganathan, and Samuel J. Danishefsky. Tetrahedron Lett. 2006, 47, 8009-8011. A valuable advance in the synthesis of carbohydrate based anticancer vaccines through extended cycloaddition chemistry. Qian Wan, Jiehao Chen, Gong Chen, and Samuel J. Danishefsky. J. Org. Chem. 2006, 71, 8244-8249. Synthesis of the biantennary N-glycan of erythropoietin. Bin Wu, Zihao Hua, J. David Warren, Krishnakumar Ranganathan, Qian Wan, Gong Chen, Zhongping Tan, Jiehao Chen, Atsushi Endo, and Samuel J. Danishefsky. Tetrahedron Lett. 2006, 47, 5577-5579. Reiterative cysteine-based coupling leading to complex, homogeneous glycopeptides. Bin Wu, J. David Warren, Jiehao Chen, Gong Chen, Zihao Hua, and Samuel J. Danishefsky. Tetrahedron Lett. 2006, 47, 5219-5223. Studies related to the relative thermodynamic stabilities of C-terminal peptidyl esters of O-hydroxy thiophenol: emergence of a doable strrategy for non-cysteine ligation applicable to the chemical synthesis of glycopeptides. Gong Chen, J. David Warren, Jiehao Chen, Bin Wu, Qian Wan, and Samuel J. Danishefsky. J. Am. Chem. Soc. 2006, 128, 7460-7462. Toward erythropoietin, part I: reiterative cysteine-based coupling leading to complex, homogeneous glycopeptides. Bin Wu, J. David Warren, Jiehao Chen, Gong Chen, Zihao Hua, and Samuel J. Danishefsky. Angew. Chem. Int. Ed. 2006, 45, 4116-4125. Synthesis of cyclic peptides and glycopeptides by native chemical ligation using in situ derived thioester. Jiehao Chen, J. David Warren, Bin Wu, Gong Chen, Qian Wan, and Samuel J. Danishefsky. Tetrahedron Lett. 2006, 47, 1969-1972. Development of metabolic imaging agents via rational design of fluorescence switch: new fluorogenic probes for monoamine oxidases. Gong Chen, Dominic J. Yee, Niko G. Gubernator, and Dalibor Sames. J. Am. Chem. Soc. 2005, 127, 4544-4545. Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling. Gong Chen, Alexander Heim, Doris Riether, Dominic J. Yee, Yelena Milgrom, Mary Ann Gawinowicz, and Dalibor Sames. J. Am. Chem. Soc. 2003, 125, 8130-8133.