个人简介
学习经历:
2009/03–2009/09,美国路易斯安那州立大学,兽医学院,高级访问学者;
2001/12–2004/03,河北师范大学,生命科学学院,博士后出站;
1998/09–2001/07,解放军军需大学,军事兽医研究所,获得农学博士学位;
1990/09–1993/07,河北师范大学,生物系,获得理学硕士学位;
1986/09–1990/07,河北师范大学,生物系,获得理学学士学位;
主要教学科研工作:
主要研究方向:动物病原微生物分子致病机制及其防控。采用现代微生物学、生物化学与分子生物学、分子免疫学等手段研究家畜家禽和主要水生动物等重要病原微生物的分子致病机理和基因工程疫苗。已完成国家自然科学基金项目2项;主持河北省科技厅科技支撑项目和河北省自然科学基金各1项。在Vaccine,JournalofImmunology,AnalBioanalChem,Hepato-Gastroenterology,Antiviralresearch,Europeanjournalofphamacology,CellularImmunology,VirusGene,BrainResearchBulletin,微生物学报,中国兽医学报等杂志共发表学术论文60余篇,获河北省科技进步三等奖2项。主持河北省《微生物学》省级精品课程,作为副主编编写《微生物学教程》和《免疫学》教材两部,发表教学改革论文20余篇,指导的本科生获全国“挑战杯”大学生科技创新大赛二等奖和三等奖各1项,获河北省优秀教学成果二等奖1项。
承担的科研项目:
1、猪重要疫病诊断防控及特色养殖关键技术研究与示范,编号13226603D,河北省科技支撑计划,2013-2015;
2、G17-PE38KDEL胃癌靶向生物学效应研究,编号C2011205115,河北省自然科学基金,2011-2013;
3、山区奶牛养殖主要疫病防控关键技术研究与开发,编号11230405D-2,河北省科技支撑计划,2011-2013;
4、绵羊肺炎支原体Y98主要外膜抗原蛋白筛选与功能鉴定,编号30871880,国家自然科学基金,2009-2011;
5、抗产气荚膜梭菌主要致死性毒素ScFv抗体库的构建,编号C2009000290,河北省自然科学基金,2011-2013。教学、科研获奖(含各种荣誉称号):
1.仔猪腹泻基因工程菌株的构建及其免疫原性研究,赵宝华、边艳青、杨英伟、田莉瑛、柏佳宁、宋杰、胡奕,河北省科技进步奖,三等奖,2011;
2.海水工厂化养殖推广,申红旗、赵宝华、李全振、曹杰英、杨振才,河北省科技进步奖,三等奖,2008。
近期论文
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[1]GuoPingLv,BaoHongXu,PeiNanWei,JieSong,HongYingZhang,ChuanZhao,LiYunQin,BaoHuaZhao(共责任作者).Molecularcharacterizationoffoodborne-associatedStaphylococcusaureusstrainsisolatedinShijiazhuang,China,from2010to2012[J].DiagnosticMicrobiologyandInfectiousDisease,2014,78(4):262-268.
[2]Qiong-YingFan,Ze-JunDong,Zheng-HuiLi,XiaYin,Xiao-YanYang,TaoFeng,KunWei,Ji-KaiLiu,Bao-HuaZhao(共责任作者).Twonewylangene-typesesquiterpenoidsfromculturesofthefungusPostiasp[J].JAsianNatProdRes,2014,16(3):254-258.
[3]ShanshanGao,NaZhao,SaidAmer,MingmingQian,MengxiLv,YuliangZhao,XinSu,JieyingCao,HongxuanHe,BaohuaZhao(共责任作者).ProtectiveefficacyofPLGAmicrospheresloadedwithdivalentDNAvaccineencodingompAgeneofaeromonasveroniiandhlygeneofaeromonashydrophilainmice[J].Vaccine,2013,40(11):1132-1139.
[4]ZhangweiXue,YiHu,ShujingXu,KouheiOhnishi,YanheMa,JiansongJu,BaohuaZhao(共责任作者).CharacterizationandpreliminarymutationanalysisofathermostablealanineracemasefromThermoanaerobactertengcongensisMB4[J].Extremophiles,2013,17(4):611-621.
[5]YanqingBian,XiujunZhao,MenghuLi,ShaohuaZeng,BaohuaZhao(责任作者).Variousrolesofastrocytesduringrecoveryfromrepeatedexposuretodifferentdosesoflipopolysaccharide[J].BehavBrainRes,2013,253:253-61.
[6]LiGao,YongqingShen,JingZhang,ChunyunLi,LiangLi,BaoenShan,BaohuaZhao(责任作者).EffectofspidervenomoninhibitionproliferationofTE13cellsinvivoandinvitro[J].ThoracicCancer,2013,4(3):306-311.
[7]胡奕,刘朋朋,张志明,卢鹤真,罗静,王承民,刘军须,赵宝华(共责任作者),何宏轩.格尔德霉素抑制高致病性禽流感病毒增殖及其所介导炎性反应研究[J].生物化学与生物物理进展,2013,40(11):1132-1139.
[8]YanqingBian,ZhuoPan,ZiyuanHou,CuiHuang,WeiLi,BaohuaZhao(责任作者).Learning,memory,andglialcellchangesfollowingrecoveryfromchronicunpredictablestress[J].BrainResearchBulletin,2012,88(5):471-476.
[9]FengyangLei,BaohuaZhao(共第一作者),RizwanulHaque,XiaofangXiong,LynnBudgeon,NeilD.Christensen,YuzhangWu,JianxunSong.Invivoprogrammingoftumorantigen-specificTlymphocytesfrompluripotentstemcellstopromotecancerimmunosurveillance[J].CancerResearch,2011,71(14):4742-4747.
[10]Zhi-HuiZheng,YiYang,Xin-HuaLu,HuaZhang,Xiao-XiShui,ChenLiu,Xiao-BoHe,QinJiang,Bao-HuaZhao(共责任作者),Shu-YiSi.Mycophenolicacidinducesadipocyte-likedifferentiationandreversalofmalignancyofbreastcancercellspartlythroughPPARγ[J].Europeanjournalofpharmacology,2011,658(1):1-8.
[11]XiaoxiShui,XinhuaLu,YanGao,ChenLiu,FengzhiRen,QinJiang,HuaZhang,BaohuaZhao(共责任作者),ZhihuiZheng.Amammaliantwo-hybridsystem-basedassayforsmall-molecularHIVfusioninhibitorstargetinggp41[J].Antiviralresearch,2011,90(1):54-63.
[12]XinGuo,Bao-HuaZhao(责任作者),Mu-XiaZhang.RiskfactorsofHelicobacterpyloriinfectionamongadultsinnorthernChina[J].Hepato-Gastroenterology,2011,58(106):306-310.
[13]Zhi-HuiZheng,Xin-HuaLu,HuaZhang,Guo-PingLv,Jian-GongHe,Bao-HuaZhao(共责任作者),Shu-YiSi.Impactsofdifferentpromotersonthemammalianone-hybridassayfordetectingnuclearreceptoragonists[J].AnalBioanalChem,2010,396(5):1721–1730.
[14]JieSong,DiShen,JieCui,BaohuaZhao(责任作者).AcceleratedevolutionofPRRSVduringrecentoutbreaksinChina[J].VirusGene,2010,41(2):241–245.
[15]BaohuaZhao(第一作者),AihuaSong,RizwanulHaque,FengyangLei,LaurenWeiler,XiaofangXiong,YuzhangWu,MichaelCroft,JianxunSong.CooperationbetweenmoleculartargetsofcostimulationinpromotingTcellpersistenceandtumorregression[J].JournalofImmunology,2009,182(11):6744-6752.