张峰 - 广州医科大学 - 生物化学与分子生物学

个人简介

张峰，男，中科院上海应用物理所理学博士，广州医科大学南山学者特聘教授，呼吸疾病国家重点实验室PI。曾在德国慕尼黑大学、马尔堡大学、美国华盛顿大学做博士后，先后访问过加州大学圣地亚哥分校与汉堡大学。主持过多项国家与省部级自然科学基金项目；迄今已发表50多篇SCI科研论文，申请多项国家发明专利。已授权专利： 1)张峰，一种针对小分子亲水药物控释的包裹方法，专利号：ZL 2013 1 0278474.8，申请日：2013-07-04；授权公告日：2013-10-09。 2）张峰，段海婷，王晓伟，张景伟，马宇星，一种基于胶体金与发光量子点二聚体的二级可选灵敏度侧向层析快速检测方法，专利号：ZL 2013 1 0694156.X，申请日：2013-12-04；授权公告日：2017-02-01。

研究领域

1)生命分子的共组装结构及活性创造（如智能药物及其载体的构建）； 2)仿生纳米材料的可控合成及其生医学应用（如细胞内、外超灵敏纳米传感器的开发）；量子生医学（如细胞间无线通讯技术的开发）。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1)Zhong, R.; Tang, Q.; Wang, S.; Zhang, H.; Zhang, F.*; Xiao, M.; Man, T.; Qu, X.; Li, L.; Zhang, W.; Pei, H.*, Self-Assembly of Enzyme-Like Nanofibrous G-Molecular Hydrogel for Printed Flexible Electrochemical Sensors. Adv Mater 2018, 30 (12), e1706887. 2)Gao, H.; Zhu, Z.; Jiang, X.; Guo, J.; Song, B.*; Zhang, F.*, Denaturation of dsDNA Induced by Specific Major Groove Binding of Cadmium Ion to Thymine. ACS Omega 2017, 2 (11), 8490-8494. 3)Yuan, M.; Li, W.; Yang, M.; Huang, X.; Bai, Z.; Liu, Y.; Cai, W.; Wang, Y.; Zhang, F.*, Affinity study on bovine serum albumin’s peptides to amphiphilic gold nanoparticles: A test of epitopes and non-epitopes. Applied Surface Science 2017, 416, 845-852. 4)Li, N.; Jang, H.; Yuan, M.; Li, W.; Yun, X.; Lee, J.; Du, Q.; Nussinov, R.; Hou, J.; Lal, R.*; Zhang, F.*, Graphite-Templated Amyloid Nanostructures Formed by a Potential Pentapeptide Inhibitor for Alzheimer's Disease: A Combined Study of Real-Time Atomic Force Microscopy and Molecular Dynamics Simulations. Langmuir 2017, 33 (27), 6647-6656. 5)Chao, J.; Zhang, P.; Wang, Q.; Wu, N.; Zhang, F.*; Hu, J.; Fan, C. H.; Li, B.*, Single-molecule imaging of DNA polymerase I (Klenow fragment) activity by atomic force microscopy. Nanoscale 2016, 8 (11), 5842-6. 6)Liu, Y.; Zhong, R.; Zhang, P.; Ma, Y.; Yun, X.; Gong, P.; Wei, J.; Zhao, X.; Zhang, F.* , Understanding the Robust Physisorption between Bovine Serum Albumin and Amphiphilic Polymer Coated Nanoparticles. ACS Applied Materials & Interfaces 2015, 8 (4), 2478-2485. 7)Zhang, F.*; Zhang, P.; Hou, J.; Yun, X.; Li, W.; Du, Q.; Chen, Y., Large Scale Anomalous Patterns of Muscovite Mica Discovered by Atomic Force Microscopy. ACS Applied Materials & Interfaces 2015, 7 (16), 8699-8705. 8)Guo, J.; Zhong, R. B.; Li, W. R.; Liu, Y. S.; Bai, Z. J.; Yin, J.; Liu, J. R.; Gong, P.; Zhao, X. M.; Zhang, F.*, Interaction study on bovine serum albumin physically binding to silver nanoparticles: Evolution from discrete conjugates to protein coronas. Applied Surface Science 2015, 359, 82-88. 9)Yuan, M.; Zhong, R. B.; Gao, H. Y.; Li, W. R.; Yun, X. L.; Liu, J. R.; Zhao, X. M.; Zhao, G. F.; Zhang, F.*, One-step, green, and economic synthesis of water-soluble photoluminescent carbon dots by hydrothermal treatment of wheat straw, and their bio-applications in labeling, imaging, and sensing. Applied Surface Science 2015, 355, 1136-1144. 10)Zhong, R. B.; Liu, Y. S.; Zhang, P.; Liu, J. R.; Zhao, G. F.; Zhang, F.*, Discrete Nanoparticle-BSA Conjugates Manipulated by Hydrophobic Interaction. ACS Applied Materials & Interfaces 2014, 6 (22), 19465-19470. 11)Zhou, X. F.; Zhang, Y. Y.; Zhang, F.*; Pillai, S.; Liu, J. H.; Li, R.; Dai, B.; Li, B.; Zhang, Y. *, Hierarchical ordering of amyloid fibrils on the mica surface. Nanoscale 2013, 5 (11), 4816-4822. 12)Zhang, F.; Lees, E.; Amin, F.; Rivera_Gil, P.; Yang, F.; Mulvaney, P.; Parak, W. J. Polymer-Coated Nanoparticles: A Universal Tool for Biolabelling Experiments. Small 2011, 7, 3113-3127.（ESI 1%） 13)Li, H.; Zhang, F.; Zhang, Y.; Ye, M.; Zhou, B.; Tang, Y.-Z.; Yang, H.-J.; Xie, M.-Y.; Chen, S.-F.; He, J.-H.; Fang, H.-P.; Hu, J. Peptide Diffusion and Self-Assembly in Ambient Water Nanofilm on Mica Surface. J Phys Chem B 2009, 113, 8795-8799. (Equal Contribution) . 14)Zhang, F.; Lin, X. J.; Ji, L. N.; Du, H. N.; Tang, L.; He, J. H.; Hu, J.; Hu, H. Y. Assembly of alpha-synuclein fibrils in nanoscale studied by peptide truncation and AFM. Biochem Bioph Res Co 2008, 368, 388-394. 15)Zhang, F.; Du, H. N.; Zhang, Z. X.; Ji, L. N.; Li, H. T.; Tang, L.; Wang, H. B.; Fan, C. H.; Xu, H. J.; Zhang, Y.; Hu, J.; Hu, H. Y.; He, J. H. Epitaxial growth of peptide nanofilaments on inorganic surfaces: Effects of interfacial hydrophobicity/hydrophilicity. Angew Chem Int Edit 2006, 45, 3611-3613. 1)Zhong, R.; Tang, Q.; Wang, S.; Zhang, H.; Zhang, F.*; Xiao, M.; Man, T.; Qu, X.; Li, L.; Zhang, W.; Pei, H.*, Self-Assembly of Enzyme-Like Nanofibrous G-Molecular Hydrogel for Printed Flexible Electrochemical Sensors. Adv Mater 2018, 30 (12), e1706887. 2)Gao, H.; Zhu, Z.; Jiang, X.; Guo, J.; Song, B.*; Zhang, F.*, Denaturation of dsDNA Induced by Specific Major Groove Binding of Cadmium Ion to Thymine. ACS Omega 2017, 2 (11), 8490-8494. 3)Yuan, M.; Li, W.; Yang, M.; Huang, X.; Bai, Z.; Liu, Y.; Cai, W.; Wang, Y.; Zhang, F.*, Affinity study on bovine serum albumin’s peptides to amphiphilic gold nanoparticles: A test of epitopes and non-epitopes. Applied Surface Science 2017, 416, 845-852. 4)Li, N.; Jang, H.; Yuan, M.; Li, W.; Yun, X.; Lee, J.; Du, Q.; Nussinov, R.; Hou, J.; Lal, R.*; Zhang, F.*, Graphite-Templated Amyloid Nanostructures Formed by a Potential Pentapeptide Inhibitor for Alzheimer's Disease: A Combined Study of Real-Time Atomic Force Microscopy and Molecular Dynamics Simulations. Langmuir 2017, 33 (27), 6647-6656. 5)Chao, J.; Zhang, P.; Wang, Q.; Wu, N.; Zhang, F.*; Hu, J.; Fan, C. H.; Li, B.*, Single-molecule imaging of DNA polymerase I (Klenow fragment) activity by atomic force microscopy. Nanoscale 2016, 8 (11), 5842-6. 6)Liu, Y.; Zhong, R.; Zhang, P.; Ma, Y.; Yun, X.; Gong, P.; Wei, J.; Zhao, X.; Zhang, F.* , Understanding the Robust Physisorption between Bovine Serum Albumin and Amphiphilic Polymer Coated Nanoparticles. ACS Applied Materials & Interfaces 2015, 8 (4), 2478-2485. 7)Zhang, F.*; Zhang, P.; Hou, J.; Yun, X.; Li, W.; Du, Q.; Chen, Y., Large Scale Anomalous Patterns of Muscovite Mica Discovered by Atomic Force Microscopy. ACS Applied Materials & Interfaces 2015, 7 (16), 8699-8705. 8)Guo, J.; Zhong, R. B.; Li, W. R.; Liu, Y. S.; Bai, Z. J.; Yin, J.; Liu, J. R.; Gong, P.; Zhao, X. M.; Zhang, F.*, Interaction study on bovine serum albumin physically binding to silver nanoparticles: Evolution from discrete conjugates to protein coronas. Applied Surface Science 2015, 359, 82-88. 9)Yuan, M.; Zhong, R. B.; Gao, H. Y.; Li, W. R.; Yun, X. L.; Liu, J. R.; Zhao, X. M.; Zhao, G. F.; Zhang, F.*, One-step, green, and economic synthesis of water-soluble photoluminescent carbon dots by hydrothermal treatment of wheat straw, and their bio-applications in labeling, imaging, and sensing. Applied Surface Science 2015, 355, 1136-1144. 10)Zhong, R. B.; Liu, Y. S.; Zhang, P.; Liu, J. R.; Zhao, G. F.; Zhang, F.*, Discrete Nanoparticle-BSA Conjugates Manipulated by Hydrophobic Interaction. ACS Applied Materials & Interfaces 2014, 6 (22), 19465-19470. 11)Zhou, X. F.; Zhang, Y. Y.; Zhang, F.*; Pillai, S.; Liu, J. H.; Li, R.; Dai, B.; Li, B.; Zhang, Y. *, Hierarchical ordering of amyloid fibrils on the mica surface. Nanoscale 2013, 5 (11), 4816-4822. 12)Zhang, F.; Lees, E.; Amin, F.; Rivera_Gil, P.; Yang, F.; Mulvaney, P.; Parak, W. J. Polymer-Coated Nanoparticles: A Universal Tool for Biolabelling Experiments. Small 2011, 7, 3113-3127.（ESI 1%） 13)Li, H.; Zhang, F.; Zhang, Y.; Ye, M.; Zhou, B.; Tang, Y.-Z.; Yang, H.-J.; Xie, M.-Y.; Chen, S.-F.; He, J.-H.; Fang, H.-P.; Hu, J. Peptide Diffusion and Self-Assembly in Ambient Water Nanofilm on Mica Surface. J Phys Chem B 2009, 113, 8795-8799. (Equal Contribution) . 14)Zhang, F.; Lin, X. J.; Ji, L. N.; Du, H. N.; Tang, L.; He, J. H.; Hu, J.; Hu, H. Y. Assembly of alpha-synuclein fibrils in nanoscale studied by peptide truncation and AFM. Biochem Bioph Res Co 2008, 368, 388-394. 15)Zhang, F.; Du, H. N.; Zhang, Z. X.; Ji, L. N.; Li, H. T.; Tang, L.; Wang, H. B.; Fan, C. H.; Xu, H. J.; Zhang, Y.; Hu, J.; Hu, H. Y.; He, J. H. Epitaxial growth of peptide nanofilaments on inorganic surfaces: Effects of interfacial hydrophobicity/hydrophilicity. Angew Chem Int Edit 2006, 45, 3611-3613.