个人简介

National Science Foundation CAREER Award, 2011 NSERC of Canada Predoctoral Fellowship, 1998-2003

研究领域

Analytical/Biological/Physical

Analytical Protein Dynamics by High Field NMR Biological Protein Dynamics in Enzyme Function and Regulation Physical Protein Dynamics by High Field NMR

近期论文

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Yang, X., E.D. Smidansky, K.R. Maksimchuk, D. Lum, J.L. Welch, J.J. Arnold, C.E. Cameron and D.D. Boehr, Motif D or viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition. Structure, 2012, 20, 1519-1527. Weikl, T.R. and D.D. Boehr, Conformational selection and induced changes along the catalytic cycle of Escherichia.coli dihydrofolate reductase. Proteins, 2012, 80, 2369-2383. Zaccardi, M.J., O. Mannweiler and D.D. Boehr, Differences in the catalytic mechanisms of mesophilic and thermophilic indole-3-clycerol phosphate synthase enzymes at their adaptive temperatures. Biochem. Biophys. Res. Commun., 2012, 418, 324-329. Boehr, D.D. Promiscuity in protein-RNA interactions: Conformational ensembles facilitate molecular recognition in the spliceosome: Conformation diversity in U2AF(65) facilitates binding to diverse RNA sequences. Biosessays, 2012, 34, 174-180. Yang, X., J.L. Welch, J.J. Arnold and D.D. Boehr, Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance. Biochemistry, 2010, 49, 9361-9371. Boehr, D.D., McElheny, D., Dyson, H.J. and Wright, P.E. Millisecond fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands. Proc. Natl. Acad. Sci. USA. 2010, 107, 1373-1378. Boehr, D.D., Nussinov, R. and Wright, P.E. The role of dynamic conformational ensembles in molecular recognition. Nat. Chem. Biol. 2009, 5, 789-796. Boehr, D.D., McElheny, D., Dyson, H.J. and Wright, P.E. The dynamic energy landscape of dihyrofolate reductase catalysis. Science, 2006, 313, 1638-1642. Boehr, D.D., Dyson, H.J and Wright, P.E. An NMR perspective on enzyme dynamics. Chem. Rev., 2006, 3055-3079.