个人简介
科研情况:
[1]国家自然科学基金青年科学基金项目,81703014,2018/01-2020/12,主持
[2]天津市教委科研计划项目,2017KJ010,2017/05-2020/04,主持
[3]国家自然科学基金面上项目,81673647,2017/01-2020/12,第二参与人
[4]国家自然科学基金青年科学基金项目,31601203,2017/01-2019/12,第二参与人
[5]中国博士后科学基金面上项目,2015M570229,2015-2016,主持,已结题
研究领域
[1]抗肿瘤药物药理作用研究
[2]抗肿瘤药物的剂型研究
近期论文
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1.LiuZ,ZhengQ,ChenWZ,WuM,PanGJ,YangK,LiXZ,ManSL,TengYO,YuP,GaoWY.ChemosensitizingeffectofParisSaponinIonCamptothecinand10-hydroxycamptothecininlungcancercellsviap38MAPK,ERK,andAktsignalingpathways.EuropeanJournalofMedicinalChemistry,2017,125:760-769.
2.LiuZ,ZhengQ,ChenWZ,ManSL,TengYO,MengX,ZhangYM,YuP,GaoWY.ParissaponinIinhibitsproliferationandpromotesapoptosisthroughdown-regulatingAKTactivityinhumannon-small-celllungcancercellsandinhibitingERKexpressioninhumansmall-celllungcancercells.RSCAdvances,2016,6:70816-70824.
3.TengYO,WangLX,LiuH,YuanY,ZhangQ,WuM,WangLY,WangHM,LiuZ*,YuP*.3"-Geranyl-mono-substitutedchalconeXanthoangelovlinducesapoptosisinhumanleukemiaK562cellsviaactivationofmitochondrialpathway.Chemico-BiologicalInteractions,2017,261:103-107.
4.LiuZ,WangJY,GaoWY,ManSL,GuoHM,ZhangJZ,LiuCX.FormulationandinvitroabsorptionanalysisofRhizomaparidissteroidalsaponins.InternationalJournalofPharmaceutics,2013,441(1-2):680-686.
5.LiuZ,LiHF,FanYY,LiuYX,ManSL,YuP,GaoWY.CombinationtreatmentwithRhizomaParidisandRhizomaCurcumalongaextractsand10-hydroxycamptothecinenhancestheantitumoreffectinH22tumormodelbyincreasingtheplasmaconcentration.Biomedicine&Pharmacotherapy,2016,83:627-634.
6.LiuZ,GaoWY,ManSL,ZhangY,LiHF,WuSS,ZhangJZ,LiuCX.SynergisticeffectsofRhizomaParidisandRhizomaCurcumalongaondifferentanimaltumormodels.EnvironmentalToxicologyandPharmacology,2014,38(1):31-40.
7.LiuZ,GaoWY,JingSS,ZhangY,ManSL,WangY,ZhangJZ,LiuCX.Correlationamongcytotoxicity,hemolyticactivityandthecompositionofsteroidalsaponinsfromParisL..JournalofEthnopharmacology,2013,149(2):422-430.
8.LiuZ,WangJY,GaoWY,ManSL,WangY,LiuCX.PreparativeseparationandpurificationofsteroidalsaponinsinParispolyphyllavar.yunnanensisbymacroporousadsorptionresins.PharmaceuticalBiology,2013,51(7):899-905.
9.LiuZ,ZhangJZ,GaoWY,LiuCX.AntinociceptiveactivityandChemicalcompositionofWei-Chang-An-Wanextracts.PharmaceuticalBiology,2013,51:790-797.
10.LiuZ,LiN,GaoWY,ManSL,YinSS,LiuCX.Comparativestudyonhemostatic,cytotoxicandhemolyticactivitiesofdifferentspeciesofParisL..JournalofEthnopharmacology,2012,142(3):789-794.
11.LiuZ,GaoWY,ManSL,WangJY,LiN,YinSS,WuSS.,LiuCX.Pharmacologicalevaluationofsedative-hypnoticactivityandgastro-intestinaltoxicityofRhizomaParidissaponins.JournalofEthnopharmacology,2012,144(1):67-72.