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研究领域

主要从事复杂生物样品微量定量及动力学分析、化学异物代谢/毒性筛选以及基于色谱-质谱技术的药物(中药)代谢物组学的基础理论与新方法研究。

近期论文

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M. Ye, L. Tang, M. Luo, J. Zhou, B. Guo*, Y. Liu, B. Chen. Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations. Nanoscale Res Lett, 2014, 9, 642. http://www.nanoscalereslett.com/content/9/1/642 A. Liu*, N. Tanaka, L. Sun, B. Guo, J.H. Kim, K.W. Krausz, Z. Fang, C. Jiang, J. Yang, F.J. Gonzalez. Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. Chem Biol Interact. 2014, 223:80-86. L. Zeng, M. Wang, Y. Yuan, B. Guo*, J. Zhou, Z. Tan, M. Ye, L. Ding, B. Chen. Simultaneous multi-component quantitation of Chinese herbal injection Yin-zhi-huang in rat plasma by using a single-tube extraction procedure for mass spectrometry-based pharmacokinetic measurement. J. Chromatogr. B, 2014, 967:245-254. L. Tang, X. Wang, B. Guo*, M. Ma, B. Chen, S. Zhan, S. Yao. Salt-triggered liquid phase separation and facile nanoprecipitation of aqueous colloidal gold dispersion in miscible biofluids for direct chromatographic measurement. RSC Adv., 2013, 3, 15875-15886. M. Wei, P. Yin , Y. Shen, L. Zhang, J. Deng, S. Xue, H. Li, B. Guo, Y. Zhang*, S. Yao. A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells. Chem. Commun. 2013, 49(41): 4640-4642. B Guo*, B Chen, A Liu, W Zhu, S Yao. Liquid chromatography-mass spectrometric multiple reaction monitoring-based strategies for expanding targeted profiling towards quantitative metabolomics. Curr. Drug Metab. 2012, 13(9): 1226-43 C Huang, B Guo*, X. Wang , J Li, W Zhu, B Chen, S Ouyang, SYao. A generic approach for expanding homolog-targeted residue screening of sulfonamides using a fast matrix separation and class-specific fragmentation-dependent acquisition with a hybrid quadrupole-linear ion trap mass spectrometer. Anal. Chim. Acta, 2012, 737, 83-98. W Zhu, Y Yuan, P Zhou, L Zeng, H Wang, L Tang, B Guo*, B Chen. The expanding role of electrospray ionization mass spectrometry in probing reactive intermediates in solution. Molecules, 2012, 17(10): 11507-37. (Invited review) http://www.mdpi.com/1420-3049/17/10/11507 H Wang, Y Wu, Y Zhao, W Sun, L Ding, B Guo, B Chen. Rapid screening of illicit additives in weight loss dietary supplements with desorption corona beam ionisation (DCBI) mass spectrometry. Food Addit Contam A. 2012, 29(8): 1194-201. H Wang, Y Wu, B Guo, W Sun, L Ding, B. Chen. Quantification of low-polar small molecules using room temperature ionic liquids matrix assisted desorption corona beam ionization. Analyst, 2012, 137(17): 3982-8. G Xu, B Chen, B Guo*, D He, S Yao*. Detection of intermediates for edvhweiler-clarke reactions by liquid-phase reactive desorption electrospray ionization mass spectrometry. Analyst, 2011, 136(11): 2385-90. G Liu, L Rong, B Guo, M Zhang, S Li, Q Wu, J Chen, B Chen, S Yao. Development of an improved method to extract pesticide residues in foods using acetontrile with magnesium sulfate and chloroform. J Chromatogr A, 2011, 1218(11): 1429–36. B Guo*, Z Huang, M Wang, X Wang, Y Zhang, B Chen, Y Li, H Yan, S Yao. Simultaneous direct analysis of benzimidazole fungicides and relevant metabolites in agricultural products based on multifunction dispersive solid-phase extraction and liquid chromatography-mass spectrometry. J Chromatogr A, 2010, 1217(29): 4796–807. M Wang, B Guo*, Z Huang, J Duan, Z Chen, B Chen, S Yao. Improved compatibility of liquid chromatography with electrospray tandem mass spectrometry for tracing occurrence of barbital homologous residues in animal tissues. J Chromatogr A, 2010, 1217(17): 2821–31. H Shen, MM He, H Liu, SA Wrighton, L Wang, B Guo, C Li. Comparative Metabolic Capabilities and Inhibitory Profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17. Drug Metab Dispos, 2007, 35(8):1292–300. B Guo, C Li*, G Wang, L Chen. Rapid and direct measurement of free concentrations of highly protein-bound fluoxetine and its metabolite norfluoxetine in plasma. Rapid Commun Mass Spectrom, 2006, 20(1): 39–47. B Guo, C Li*, Z Deng, S Chen, Z Ji, J Zhang, M Chen, F Xu. A new method for measurement of (-)-sophocarpine, a candidate therapeutic for viral myocarditis, in plasma: application to a toxicokinetic study in beagle dogs. Rapid Commun Mass Spectrom, 2005, 19(19): 2840–8. B Guo, Y Yuan, Y Wu, Q Xie, S Yao*. Assay and analysis for anti- and pro-oxidative effects of ascorbic acid on DNA with bulk acoustic wave impedance technique. Anal Biochem, 2002, 305(2): 139–48. 郭宾*, 段俊敏, 王美玲, 王晓莹, 陈波. 自动流注-串联质谱法快速筛选植物提取物对药物代谢酶的抑制潜性. 分析化学, 2010, 38(12): 1692-7. 郭宾,戴仁科*,代谢组学及其研究策略和分析方法进展,中国卫生检验杂志,2007, 17(3): 554-63.

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