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个人简介

教育经历: 2010/9-2014/6,天津大学,应用化学,工学博士 2002/9-2006/3,中国科学院微生物研究所,生物化学与分子生物学专业,硕士 1998/9-2002/6,湖南师范大学,生物科学,学士 工作经历: 2014/12-至今,天津科技大学,生物工程学院,副研究员 2009/12-2014/11,天津科技大学,生物工程学院,助理研究员 2006/8-2009/11,天津科技,生物工程学院,研究实习员 主讲课程: 本科生:发酵过程检测与控制;研究生:生物过程检测与控制 科研情况 主持并参与国家级和省部级等项目十余项,主持的 [1]国家自然科学基金项目:高核酸酿酒酵母RNA合成的分子遗传机制研究,31671834、2017-2020,主持 [2]国家自然科学基金项目:全局转录因子σ定向进化提高肺炎克雷伯氏菌发酵木糖生产2,3-丁二醇能力的研究及其调控机理,21406168、2015-2017,主持 [3]中国博士后科学基金面上项目:放线菌在白酒生产中的作用及其机制研究,2017M611169,2017-2019 [4]天津市应用基础及前沿技术研究计划:适量高产酯酿酒酵母优良基因工程菌种的选育,12JCQNJC06500、2012-2015,主持 [5]国家科技支撑项目子课题:食品安全朔源控制及预警技术研究与推广应用示范---酵母安全生产与质量控制,主持 [6]横向课题:安徽文王酿酒股份有限公司菌种鉴定与相关标准制定,主持

研究领域

[1]现代酿造技术与食品安全;[2]生物基化学品与合成生物学;[3]酵母生物学

近期论文

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1.Guo,XW*;Zhang,Y;Li,LL;Guo,J;Wu,DG;Chen,YF;Xiao,DG,Improvedxylosetoleranceand2,3-butanediolproductionofKlebsiellapneumoniaebydirectedevolutionofrpoDandthemechanismsrevealedbytranscriptomics,BiotechnolBiofuels,2018,11:307doi:10.1186/s13068-018-1312-8 2.LiP,GaoY,WangC,ZhangCY,GuoX,XiaoD.EffectofILV6DeletionandExpressionofaldBfromLactobacillusplantaruminSaccharomycesuvarumonDiacetylProductionandWineFlavor.JAgricFoodChem.2018,66(32):8556-8565.doi:10.1021/acs.jafc.8b02356. 3.LiF,YinC,SunL,LiY,GuoX,SongH.SyntheticKlebsiellapneumoniae-ShewanellaoneidensisConsortiumEnablesGlycerol-FedHigh-PerformanceMicrobialFuelCells.BiotechnolJ.2018;13(5):e1700491.doi:10.1002/biot.201700491. 4.GuoJ,HuangS,ChenY,GuoX,XiaoD.HeterologousexpressionofSpathasporapassalidarumxylosereductaseandxylitoldehydrogenasegenesimprovedxylosefermentationabilityofAureobasidiumpullulans.MicrobCellFact.2018;17(1):64.doi:10.1186/s12934-018-0911-1. 5.LiW,ChenSJ,WangJH,ZhangCY,ShiY,GuoXW,ChenYF,XiaoDG.GeneticengineeringtoaltercarbonfluxforvarioushigheralcoholproductionsbySaccharomycescerevisiaeforChineseBaijiufermentation.ApplMicrobiolBiotechnol.2018;102(4):1783-1795.doi:10.1007/s00253-017-8715-5. 6.GuoJ,HuangS,ChenY,GuoX,XiaoD.Discoveringtheroleoftheapolipoproteingeneandthegenesintheputativepullulanbiosynthesispathwayonthesynthesisofpullulan,heavyoilandmelanininAureobasidiumpullulans.WorldJMicrobiolBiotechnol.2018;34(1):11.doi:10.1007/s11274-017-2398-z. 7.Guo,XW*;Wang,YZ;Guo,J;Wang,Q;Zhang,Y;Chen,YF;Zhang,CY;Xiao,DG,Efficientproductionof2,3-butanediolfromcheesewheypowder(CWP)solutionbyKlebsiellapneumoniaethroughintegratingpulsedfed-batchfermentationwithatwo-stagepHcontrolstrategy,Fuel,2017,203:469-477DOI:10.1016/j.fuel.2017.04.138 8.LiP,GuoX*,ShiT,HuZ,ChenY,DuL,XiaoD*.ReducingdiacetylproductionofwinebyoverexpressingBDH1andBDH2inSaccharomycesuvarum.JIndMicrobiolBiotechnol.2017;44(11):1541-1550.doi:10.1007/s10295-017-1976-2. 9.ShiTT,LiP,ChenSJ,ChenYF,GuoXW*,XiaoDG*.ReducedproductionofdiacetylbyoverexpressingBDH2geneandILV5geneinyeastofthelagerbrewerswithoneILV2allelicgenedeleted.JIndMicrobiolBiotechnol.2017;44(3):397-405.doi:10.1007/s10295-017-1903-6. 10.SongL,ChenY,DuY,WangX,GuoX,DongJ,XiaoD.SaccharomycescerevisiaeproteinaseAexcretionandwinemaking.WorldJMicrobiolBiotechnol.2017;33(11):210.doi:10.1007/s11274-017-2361-z. 11.GuoJ,WangY,LiB,HuangS,ChenY,GuoX,XiaoD.Developmentofaone-stepgeneknock-outandknock-inmethodformetabolicengineeringofAureobasidiumpullulans.JBiotechnol.2017,251:145-150.doi:10.1016/j.jbiotec.2017.04.029. 12.YuH,GuoJ,ChenY,FuG,LiB,GuoX,XiaoD.Efficientutilizationofhemicelluloseandcelluloseinalkaliliquor-pretreatedcorncobforbioethanolproductionathighsolidloadingbySpathasporapassalidarumU1-58.BioresourTechnol.2017;232:168-175.doi:10.1016/j.biortech.2017.01.077. 13.ChenY,SongL,HanY,LiuM,GongR,LuoW,GuoX,XiaoD.DecreasedproteinaseAexcretionbystrengtheningitsvacuolarsortingandweakeningitsconstitutivesecretioninSaccharomycescerevisiae.JIndMicrobiolBiotechnol.2017;44(1):149-159.doi:10.1007/s10295-016-1868-x. 14.GuoXW,LiYZ,GuoJ,WangQ,HuangSY,ChenYF,DuLP,XiaoDG.ReducedproductionofethylcarbamateforwinefermentationbydeletingCAR1inSaccharomycescerevisiae.JIndMicrobiolBiotechnol.2016;43(5):671-9.doi:10.1007/s10295-016-1737-7. 15.ChenY,LuoW,GongR,XueX,GuanX,SongL,GuoX,XiaoD.ImprovedethylcaproateproductionofChineseliquoryeastbyoverexpressingfattyacidsynthesisgeneswithOPI1deletion.JIndMicrobiolBiotechnol.2016;43(9):1261-70.doi:10.1007/s10295-016-1795-x. 16.GuoJ,LiJ,ChenY,GuoX,XiaoD.ImprovingErythritolProductionofAureobasidiumpullulansfromXylosebyMutagenesisandMediumOptimization.ApplBiochemBiotechnol.2016;180(4):717-727. 17.Shi,TT;Guo,XW;Li,P;Zhou,Z;Xiao,DG,Diacetylcontentreductioninindustrialbrewer'syeastthroughILV2disruptionandBDH1expression,EuropeanFoodResearchandTechnology,2016,242(6):919-926DOI:10.1007/s00217-015-2598-4 18.Zhang,CY;Li,W;Wang,DS;Guo,XW;Ma,LJ;Xiao,DG,Productionof2,3-butanediolbyEnterobactercloacaefromcorncob-derivedxylose,TurkishJournalofBiology,2016,40(4):856-865DOI:10.3906/biy-1506-66 19.GuoX,GuanX,WangY,LiL,WuD,ChenY,PeiH,XiaoD.ReductionofbiogenicaminesproductionbyeliminatingthePEP4geneinSaccharomycescerevisiaeduringfermentationofChinesericewine.FoodChem.2015;178:208-11.doi:10.1016/j.foodchem.2015.01.089. 20.Chen,YF;Huang,WL;Fu,GX;Guo,J;Liu,MM;Guo,XW;Xiao,DG,Agenetictransformationprotocolforthexylose-fermentingyeastSpathasporapassalidarum,EngineeringinLifeSciences,2015,15(5):550-555DOI:10.1002/elsc.201400232 21.DongJ,XuH,ZhaoL,ChenY,ZhangC,GuoX,HouX,ChenD,ZhangC,XiaoD.EnhancedacetateesterproductionofChineseliquoryeastbyoverexpressingATF1throughpreciseandseamlessinsertionofPGK1promoter.JIndMicrobiolBiotechnol.2014;41(12):1823-8.doi:10.1007/s10295-014-1522-4. 22.GuoX,CaoC,WangY,LiC,WuM,ChenY,ZhangC,PeiH,XiaoD.Effectoftheinactivationoflactatedehydrogenase,ethanoldehydrogenase,andphosphotransacetylaseon2,3-butanediolproductioninKlebsiellapneumoniaestrain.BiotechnolBiofuels.2014;7(1):44.doi:10.1186/1754-6834-7-44 23.GuoXW,ZhangYH,CaoCH,ShenT,WuMY,ChenYF,ZhangCY,XiaoDG.Enhancedproductionof2,3-butanediolbyoverexpressingacetolactatesynthaseandacetoinreductaseinKlebsiellapneumoniae.BiotechnolApplBiochem.2014;61(6):707-15.doi:10.1002/bab.1217 24.ZhangCY,PengXP,LiW,GuoXW,XiaoDG.Optimizationof2,3-butanediolproductionbyEnterobactercloacaeinsimultaneoussaccharificationandfermentationofcorncobresidue.BiotechnolApplBiochem.2014;61(5):501-9.doi:10.1002/bab.1198. 25.ChenY,LiF,GuoJ,LiuG,GuoX,XiaoD.EnhancedethylcaproateproductionofChineseliquoryeastbyoverexpressingEHT1withdeletedFAA1.JIndMicrobiolBiotechnol.2014;41(3):563-72.doi:10.1007/s10295-013-1390-3. 26.Chen,YF;Guo,J;Li,;Liu,MM;Zhang,XX;Guo,XW;Xiao,DG,ProductionofpullulanfromxyloseandhemicellulosehydrolysatebyAureobasidiumpullulansAY82withpHcontrolandDL-dithiothreitoladdition,BiotechnologyandBioprocessEngineering,2014,19(2):282-288DOI:10.1007/s12257-013-0715-4 27.Chen,YF;Zhang,XX;Zhang,SJ;Qin,WJ;Guo,CH;Guo,XW;Xiao,DG,Enhancedenzymaticxylose/cellulosefractionationfromalkalineliquor-pretreatedcorncobbysurfactantadditionandseparatefermentationtobioethanol,TurkishJournalofBiology,2014,38(4):478-484DOI:10.3906/biy-1310-16 28.ZouJ,GuoX,ShenT,DongJ,ZhangC,XiaoD.Constructionoflactose-consumingSaccharomycescerevisiaeforlactosefermentationintoethanolfuel.JIndMicrobiolBiotechnol.2013;40(3-4):353-63.doi:10.1007/s10295-012-1227-5. 29.WuD,GuoX,LuJ,SunX,LiF,ChenY,XiaoD.Arapidandefficientone-stepsite-directeddeletion,insertion,andsubstitutionmutagenesisprotocol.AnalBiochem.2013;434(2):254-8.doi:10.1016/j.ab.2012.11.028. 30.DongBY,ChenYF,ZhaoCC,ZhangSJ,GuoXW,XiaoDG.Simultaneousdeterminationoffurfural,aceticacid,and5-hydroxymethylfurfuralincorncobhydrolysatesusingliquidchromatographywithultravioletdetection.JAOACInt.2013;96(6):1239-44. 31.Zhang,JW;Zhang,CY;Dai,LH;Dong,J;Liu,YL;Guo,XW;Xiao,DG,Effectsofoverexpressionofthealcoholacetyltransferase-encodinggeneATF1anddisruptionoftheesterase-encodinggeneIAH1ontheflavourprofilesofChineseyellowricewine,InternationalJournalofFoodScience&Technology,2012,47(12):2590-2596DOI:10.1111/j.1365-2621.2012.03140.x 32.Guo,XW;Wang,RS;Chen,YF;Xiao,DG,Intergenericyeastfusantswithefficientethanolproductionfromcheesewheypowdersolution:ConstructionofaKluyveromycesmarxianusandSaccharomycescerevisiaeAY-5hybrid,EngineeringinLifeSciences,2012,12(6):656-661DOI:10.1002/elsc.201100112 33.Lu,J;Dong,J;Wu,DG;Chen,YF;Guo,XW;Shi,Y;Sun,X;Xiao,DG,Constructionofrecombinantindustrialbrewer'syeastwithlowerdiacetylproductionandproteinaseAactivity,EuropeanFoodResearchandTechnology,2012,235(5):951-961DOI:10.1007/s00217-012-1821-9 34.ChenY,YangX,ZhangS,WangX,GuoC,GuoX,XiaoD.DevelopmentofSaccharomycescerevisiaeproducinghigherlevelsofsulfurdioxideandglutathionetoimprovebeerflavorstability.ApplBiochemBiotechnol.2012;166(2):402-13.doi:10.1007/s12010-011-9436-3. 35.GuoX,ZhouJ,XiaoD.ImprovedethanolproductionbymixedimmobilizedcellsofKluyveromycesmarxianusandSaccharomycescerevisiaefromcheesewheypowdersolutionfermentation.ApplBiochemBiotechnol.2010;160(2):532-8.doi:10.1007/s12010-008-8412-z. 36.XiaoD,WuS,ZhuX,ChenY,GuoX.Effectsofsoyafattyacidsoncassavaethanolfermentation.ApplBiochemBiotechnol.2010;160(2):410-20.doi:10.1007/s12010-008-8344-7.

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