个人简介
科研情况
[1]国家自然科学基金面上项目:酿酒酵母蛋白激酶A催化亚基抑制环腺苷酸合成的调控机制研究,主持人,63万,2017.01-2020.12
[2]国家自然科学基金青年项目:酿酒酵母蛋白激酶A催化亚基细胞定位对其功能特异性的调控机制研究,主持人,23万,2014.01-2016.12
[3]天津市高等学校科技发展基金计划项目:酿酒酵母酯合成代谢机理研究与适量高产酯菌种的选育,主持人,4万,2011.11-2013.7
[4]国家自然科学基金面上项目:胁迫条件下酿酒酵母蛋白酶A胞外分泌机制研究,第二主持人,85万,2013.01-2016.12
[5]天津市科委应用基础及前沿技术研究计划项目:耐冷冻面包酵母基因工程菌种的选育,第二主持人,20万,2010.04-2013.03
[6]天津科技大学科学研究基金:酿酒酵母腺苷酸环化酶对细胞胁迫耐受性调控机制研究,主持人,0.5万,2012.12-2014.06
研究领域
[1]酿造酒(白酒、啤酒)用酵母、面包酵母、燃料乙醇酵母育种以及菌种工业应用;
[2]真核细胞信号转导理论研究:以真核细胞模式生物——芽殖酵母为研究对象,研究环腺苷酸信号通路调控和反馈抑制分子机制
近期论文
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[1]JianDong,DidiChen,GuangluWang,CuiyingZhang,LipingDu,ShanshanLiu,YuZhao,DongguangXiao*,Improvingfreeze.toleranceofbaker’syeastthroughseamlessgenedeletionofNTH1andPUT1,JournalofIndustrialMicrobiology&Biotechnology,Vol.43,2016,pp817–828
[2]JianDong,HaiyanXu,LibinZhao,YefuChen,CuiyingZhang,XuewuGuo,XiaoyueHou,DidiChen,ChenxiZhang,DongguangXiao*.EnhancedacetateesterproductionofChineseliquoryeastbyoverexpressingATF1throughpreciseandseamlessinsertionofPGK1promoter,JournalofIndustrialMicrobiology&Biotechnology,Vol.41,2014,pp1823-1828.
[3]JianDong,GuangluWang,CuiyingZhang,HaigangTan,XiSun,MingyueWu,DongguangXiao*.Atwo-stepintegrationmethodforseamlessgenedeletioninbaker’syeast,AnalyticalBiochemistry,Vol.439,2013,pp30–36.
[4]JianDong,XiaojiaBai,ThemembranelocalizationofRas2pandtheassociationbetweenCdc25pandRas2-GTPareregulatedbyProteinKinaseA(PKA)intheyeastSaccharomycescerevisiae,FEBSLetters,Vol.585,2011,pp.1127-1134.
[5]JianDong,AiliZhang,XiaojiaBai,HuanshengZhao,YunHu,FeedbackregulationofRas2guaninenucleotideexchangefactor(Ras2-GEF)activityofCdc25pbyCdc25pphosphorylationintheyeastSaccharomycescerevisiae,FEBSLetters,Vol.584,2010,pp.4745-4750.
[6]XiaojiaBai*,JianDong,Serine214ofRas2pplaysaroleinthefeedbackregulationoftheRas-cAMPpathwayintheyeastSaccharomycescerevisiae,FEBSLetters,Vol.584,2010,pp.2333-2338.