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个人简介

申雁冰,博士,天津科技大学生物工程学院副教授,硕士生导师。天津市“131”人才计划第三层次人选,天津市“131”创新型人才团队和天津市创新人才推进计划重点领域创新团队成员,中国微生物学会会员,入选首届天津市高校“优秀青年教师资助计划”。 主讲课程: 本科生:《生物药物合成原理》,《生物制药工艺学》 研究生:《生物制药技术》 主要教学研究及成果情况 参与教改项目1项,参编专著1部。 [1]天津市高等学校本科教学质量与教学改革研究计划项目:制药工程专业特色建设的综合改革与实践,2014-2016,参与 [2]第二届全国大学生生命科学创新创业大赛全国二等奖指导教师,2017。 [3]第三届全国大学生生命科学创新创业大赛全国一等奖指导教师,2018。 科研项目情况: [1]国家自然科学基金项目:环糊精介质中甾体结构与微生物催化活性的关系和基于活化效应的作用机制研究,2015-2017,项目主持人 [2]天津市自然科学基金“简单节杆菌C1,2位脱氢酶底物催化特异性机制研究及理性改造”2018-2021,项目主持人 [3]天津市科技特派员项目:基于环糊精和细胞共循环的甾体绿色生物转化工艺研究,2018-2019,项目主持人 [4]天津市应用基础与前沿技术研究计划项目:“环糊精介质中甾体结构与C1,2脱氢反应的变化规律及机制”2013-2016,项目主持人 [5]天津市高等学校科技发展基金计划项目“超分子介质生物催化中主体化合物的选择策略研究”,2012-2015,项目主持人 [6]教育部科学技术研究重点项目“AD生物合成关键酶KsdD的稳定性分析与菌株构建”2014-2016,排名第二 [7]国家863计划子课题“生物法合成去氢胆固醇技术研究”,2011-2016 [8]国家自然科学基金项目:“Mycrobacteriumneoaurum生物合成AD的产物迁移机制与调控”,2013-2016,排名第二 [9]天津市科技计划项目“环糊精介质中甾体药物及中间体生物转化工艺中试”,2015-2018,排名第二 [10]国家自然科学基金面上项目:“环糊精介质对微生物催化反应物质转运的影响及其调控”,2011-2013,主要完成人 [11]天津市应用基础及前沿技术研究计划重点项目“强心苷药物的微生物转化与活性筛选“,2008-2011主要完成人获奖情况: 优良果醋饮料发酵菌种选育及发酵关键技术研究与应用,获2015年度天津市科学技术进步奖一等奖。

研究领域

[1]具有重要医药价值的工业微生物菌种筛选与改良; [2]微生物细胞催化反应与过程调控。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

[1]ZhaoYQ,ShenYB*,MaS,LuoJM,OuyangW,ZhouHJ,TangR,WangM*.Poductionof5a-androstene-3,17-dionefromphytosterolsbyco-expressionof5a-reductaseandglucose-6-phosphatedehydrogenaseinengineeredMycobacteriumneoaurum,GreenChemistry,2019,21,1809-1815 [2]ZhouXL,ZhangY,ShenYB*,ZhangX,XuSP,ShangZH,XiaML,WangM*,EfficientproductionofandrostenedionebyrepeatedbatchfermentationinwastecookingoilmediathroughregulatingNAD+/NADHratioandstrengtheningcellvitalityofMycobacteriumneoaurum,BioresourceTechnology,2019,279:209-217. [3]TangR,ShenYB*,WangM*,ZhouHJ,ZhaoYQ.Highlyefficientsynthesisofboldenonefromandrost-4-ene-3,17-dionebyArthrobactersimplexandPichiapastorisorderedbiotransformation[J].BioprocessandBiosystemsEngineering.2019,42(6),933-940 [4]TangR,ShenYB,XiaML,TuLN,LuoJM,GengYH,GaoT,ZhouHJ,ZhaoYQ,WangM*.Ahighlyefficientstep-wisebiotransformationstrategyfordirectconversionofphytosteroltoboldenone.BioresourceTechnology,2019,283:242–250 [5]ShenYB,NiuLL,YuZQ,WangM*,ShangZH,YangY.Sodiumalginate-graftedβ-cyclodextrinsasamatrixforimmobilizedArthrobactersimplexforcortisoneacetatebiotransformation,AppliedSurfaceScience,2018,444:42-47. [6]LiuJJ,WangLF,ShenYB*,SuLQ,WangM*.Effectofβ-cyclodextrinsDerivativesonSteroidsBiotransformationbyArthrobactersimplex,AppliedBiochemistryandBiotechnology,2018,185(4),1004-1013. [7]SuLQ,ShenYB*,XiaML,ShangZH,XuSP,AnXJ,WangM*.Overexpressionofcytochromep450125inMycobacterium:arationalstrategyinthepromotionofphytosterolsbiotransformation,JournalofIndustrialMicrobiologyandBiotechnology,2018,45(10):857-86. [8]SuLQ,ShenYB*,ZhangWK,GaoT,ShangZH,WangM*.CofactorengineeringtoregulateNAD+/NADHratiowithitsapplicationtophytosterolsbiotransformation[J].MicrobialCellFactories,2017,16(1):182. [9]ShenYB,YuZQ,YangX,WangF,WangM*.Anewtechniqueforpromotingcyclicutilizationofcyclodextrinsinbiotransformation,JournalofIndustrialMicrobiologyandBiotechnology,2017,44(1):1-7. [10]WangLF,ShenYB,LiuMJ,TangR,WangM*.Influenceofimidazolium-basedionicliquidsonthesteroidbiotransformationbyArthrobactersimplex[J].JournalofChemicalTechnology&Biotechnology,2018,93(2):426-431. [11]QinN,ShenYB*,YangX,SuLQ,TangR,LiW,WangM*.Site-directedmutagenesisunderthedirectionofin-silicoproteindockingmodelingrevealstheactivesiteresiduesof3-ketosteroid-Δ1-dehydrogenasefromMycobacteriumneoaurum,WorldJournalofMicrobiologyandBiotechnology,2017,33:146. [12]SuLQ,ShenYB*,GaoT,LuoJM,WangM*.ImprovementofADbiosynthesisandcofactorsanalysisresponsetoenhancedoxygentransferbyoxygenvectorsinMycobacteriumneoaurumTCCC11979,AppliedBiochemistryandBiotechnology,2017,182:1564-1574. [13]QiaoYQ,ShenYB*,HuangW,WangYP,RenJJ,XiaT,WangM.Biocatalyst-mediatedproductionof11α,15α-dihydroxyderivativesofandrost-1,4-dien-3,17-dione,JournalofBioscienceandBioengineering,2017,123(6):692-697. [14]TangR,ShenYB,WangM*,ZhaiY,GaoQ.Highlychemoselectiveandefficientproductionof2,6-difluorobenzamideusingRhodococcusruberCGMCC3090restingcells.[J].JournalofBioscience&Bioengineering,2017,124(6):641-646. [15]ShenYB,WangLF,LiangJT,TangR,WangM*.Effectsoftwokindsofimidazolium-basedionicliquidsonthecharacteristicsofsteroid-transformationArthrobactersimplex[J].MicrobialCellFactories,2016,15:118. [16]ShenYB,WangF,WangYP,ZhaoQ,WangM*.CyclicutilizationofHP-b-CDinthebioconversionofcortisoneacetatebyArthrobactersimplex[J].BiotechnolLett,2016,38:597-602. [17]LiuY,ShenYB*,QiaoYQ,SuLQ,LiC,WangM*.Theeffectof3-ketosteroid-Δ1-dehydrogenaseisoenzymesonthetransformationofADto9α-OH-ADbyRhodococcusrhodochrousDSM43269[J].JournalofIndustrialMicrobiologyandBiotechnology,2016,43:1303-1311. [18]LiuY,CaoF,XiongH,ShenYB,WangM*.Applicationof2,4-Dinitrophenyl-hydrazine(DNPH)inHigh-ThroughputScreeningforMicroorganismMutantsAccumulating9α-Hydroxyandrost-4-ene-3,17-dione(9α-OHAD)[J].PLOSONE,2016,10(11). [19]ShenYB,LiangJT,LiHN,WangM*.Hydroxypropyl-β-cyclodextrin-mediatedalterationsincellpermeability,lipidandproteinprofilesofsteroid-transformingArthrobactersimplex[J].AppliedMicrobiologyandBiotechnology,2015,99(1):387-397. [20]XieRL,ShenYB,QinN,WangYB,SuLQ,WangM*.GeneticdifferencesinksdDinfluenceontheADD/ADratioofMycobacteriumneoaurum[J].JournalofIndustrialMicrobiologyandBiotechnology,2015,42:507-513. [21]ChenX,ShenYB,LiangQK,FlavellR,HongZY,YinZN,WangM*.EffectofBavachininanditsderivativesonTcelldifferentiation[J].InternationalImmunopharmacology,2014,19(2):399-404. [22]LuoJM,LiangQK,ShenYB,ChenX,YinZN,WangM*.Biotransformationofbavachininbythreefungalcellcultures[J].JournalofBioscienceandBioengineering,2014,117(2):191-196. [23]ShenYB,WangM*,LiXD,ZhangJL,SunH,LuoJM.Highlyefficientsynthesisof5-cyanovaleramidebyRhodococcusruberCGMCC3090restingcells.JournalofChemicalTechnologyandBiotechnology.2012,87:1396-1400. [24]ShenYB,WangM*,LiHN,WangYB,LuoJM.Influenceofhydroxypropyl-β-cyclodextrinonphytosterolbiotransformationbydifferentstrainsofMycobacteriumneoaurum.JournalofIndustrialMicrobiologyandBiotechnology.2012,39(9),1253-1259. [25]CuiLY,ShenYB,GuoXD,WangYZ,LuoJM,WangM*.EffectsofHP-β-CDongrowthandmorphologyofAbsidiacoerulea.WorldJournalofMicrobiologyandBiotechnology,2012,28(8):2723-2729. [26]ShenYB,WangM*,ZhangLT,MaYH,MaB,ZhengY,LiuH,LuoJM.Effectsofhydroxypropyl-β-cyclodextrinoncellgrowth,activity,andintegrityofsteroid-transformingArthrobactersimplexandMycobacteriumsp.AppliedMicrobiologyandBiotechnology,2011,90(6):1995-2003.

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