个人简介
刁爱坡，博士，天津市特聘教授，硕士生和博士生导师。2001年获英国TheUniversityofHertfordshire博士学位，2001-2008年英国曼彻斯特大学生命科学学院博士后，2009年任天津科技大学生物工程学院教授。入选教育部新世纪优秀人才支持计划，主持国家自然科学基金，天津市自然科学基金等科研项目。
主讲课程
本科生：分子生物学，基因工程药物
研究生：分子生物学，基因工程制药
申请专利：
[1]刁爱坡，李玉银，郁彭，宋宁，王啊丽。一种吲哚酮类化合物的新用途。2018101008225
[2]刁爱坡，李玉银，郁彭，赵苗苗，陈月，李丙旭。一种苯甲酸酯类化合物及其制备方法与应用。2017113456980
[3]刁爱坡，李玉银，郁彭，刘阳，李志鹏。一种吲哚酮类化合物及其制备方法与应用。2017114061733
近期论文
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[1]LiY,WangJ,SongN,ZengF,ZhaoM,WangA,ChenY,JingL,YuP,DiaoA*.2-(2-nitrobenzylidene)indolin-3-onecompoundinhibitstransmembraneprostateandrogen-inducedprotein(TMEPAI)expressionandcancercellproliferation.CellProlif.2018,51(5):e12469.
[2]TianZhao,ZhipengLi,ZhouliangGuo,AliWang,ZhenxingLiu,QingZhao,YuyinLi,EdwardA.McKenzie,AipoDiao*.FunctionalrecombinanthumanLegumainproteinexpressioninPichiapastoristoenablescreeningforLegumainsmallmoleculeinhibitors.ProteinExpressionandPurification.2018,150:12-16.
[3]YuyinLi,GuojunPan,YueChen,QianYang,TiantianHao,LianboZhao,LongZhao,YushengCong,AipoDiao*,PengYu*.Inhibitorofthehumantelomerasereversetrancriptase(hTERT)genepromoterinducescellapoptosisviaamitochondrial-dependentpathway.EuropeanJournalofMedicinalChemistry.2017145:370-378
[4]LiuZ,HuoX,ZhaoS,YangJ,ShiW,JingL,LiW,LiY,MaL,GaoY,DiaoA*.LowdensitylipoproteinreceptorclassAdomaincontaining4(LDLRAD4)promotestumorigenesisofhepaticcancercells.ExpCellRes.20176:30475-5.
[5]ShenhengLuo,LeiJing,TianZhao,YuyinLi,ZhenxingLiu,AipoDiao*.UbiquitinationanddynactinregulateTMEPAIlysosomaltrafficking.SciRep.20177:42668.
[6]YuyinLi,AilongGuo,JianjunWang,YaliYan,LeiJing,ShenhengLuo,XingNiu,LifangJing,BoJiang,MengYang,ZhenxingLiu,LongMa,AipoDiao*.Sp1transcriptionfactorspromoteTMEPAIgeneexpressionandcontributetotumorigenesis.CellProliferation201649(6):710-719.
[7]YuyinLi,YuejunSun,LifangJing,JianjunWang,YaliYan,YajuanFeng,YueyingZhang,ZhenxingLiu,LongMa,AipoDiao*.LysosomeinhibitorsenhancethechemotherapeuticactivityofdoxorubicininHepG2cells.Chemotherapy201662(2):85-93.
[8]LuoS1,YangM1,LvD1,JingL1,LiY1,LiuZ1,DiaoA*.TMEPAIincreaseslysosomestabilityandpromotesautophagy.IntJBiochemCellBiol.201676:98-106.
[9]YuyinLi,LiZhang,JieZhou,ShenhengLuo,RuiHuang,ChangcaiZhaoandAipoDiao*.Nedd4E3ubiquitinligasepromotescellproliferationandautophagy.CellProliferation201548(3):338-347.
[10]JianliDang,LeiJing,WeiweiShi,PingQin,YuyinLi,AipoDiao*.Expressionandpurificationofactiverecombinanthumanbonemorphogenetic7-2dimerfusionprotein.ProteinExpressionandPurification2015115:61-68.
[11]XilongBai,LeiJing,YinchuanLi,YuyinLi,ShenhengLuo,ShashaWang,JieZhou,ZheLiu,AipoDiao*.TMEPAIinhibitsTGF-βsignalingbypromotinglysosomedegradationofTGF-βreceptorandcontributestolungcancerdevelopment.CellularSignalling201426:2030-2039.
[12]KouKunyuan,DangJianli,ZhangBaoxia,WuGuanrong,LiYuyin,DiaoAipo*.EstablishmentofamethodtomeasuretheinteractionbetweenNedd4andUbCH5cfordrugscreening.Proceedingsofthe2014InternationalConferenceonAppliedBiotechnology.
[13]AipoDiao,LauraFrost,YuichiMorohashiandMartinLowe.CoordinationofgolgintetheringandSNAREassembly:GM130bindssyntaxin5inap115-regulatedmanner.JournalofBiologicalChemistry.2008283(11):6957-67.
[14]Chi-FangChiu,YashodaGhanekar,LauraFrost,AipoDiao,DanielMorrison,EdwardMcKenzieandMartinLowe.ZFPL1,anovelringfingerproteinrequiredforcis-GolgiintegrityandefficientERtoGolgitransport.EMBOJournal200827(7):934-47.
[15]NooraHyvola,AipoDiao,EddieMckenzie,AlisonSkippen,ShamshadCockcroftandMartinLowe.MembranetargetingandactivationoftheLowesyndromeproteinOCRL1byrab1GTPases.EMBOJournal200625(16):3750-61.
[16]Choudhury,R.,Diao,A.,Zhang,F.,Eisenberg,E.,Saint-Pol,A.,Williams,C.,Konstantakopoulos,A.,Lucocq,J.,Johannes,L.,Rabouille,C.,Greene,L.andLowe,M.LowesyndromeproteinOCRL1interactswithclathrinandregulatesproteintraffickingbetweenendosomesandthetrans-Golginetwork.MolecularBiologyoftheCell200816(8):3467-79.
[17]Diao,A.andLowe,M.TheGolgigoesfission.Science2004305,48-49.
[18]Diao,A.,Rahman,D.,Pappin,D.J.C.,Lucocq,J.andLowe,M.Thecoiled-coilmembraneproteingolgin-84isanovelrabeffectorrequiredforGolgiribbonformation.JournalofCellBiology2003160,201-212.
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