个人简介
马文建,博士,天津市特聘教授,博导。山东大学学士,中科院生物物理所硕士,德国科隆大学(UniversityofCologne)博士,美国NIH环境健康研究所(NIEHS)博士后。天津转基因生物安全指导委员会执法专家;天津生物医学工程学会,美国微生物学会(ASM),细胞生物学会(ASCB)等会员;德国斯普林格(Springer)国际出版公司《癌症百科全书》辞条编写成员;任CancerLetters,Genetics,Toxicology&AppliedPharmacology,ToxicologyLetters,JournalofMolecularBiology,MutationResearch,JournalofPhotochemistry&Photobiology,BiochemicalJournal等国际期刊审稿人。
主讲课程
本科生:细胞生物学(英文)
研究生:新药研究与开发;科技论文写作等
科研项目情况
[1]国家重点研发项目“益生菌健康功能与基于肠道微生物组学的食品营养代谢机理研究”(2017-2020,2314万),子课题负责人
[2]天津市131创新型人才团队“天津科技大学微生态调控与分子药理学团队”(2018-2020,120万),骨干成员
[3]天津市高等学校创新团队“基于肠道微生态调控的食品营养功能和安全评价”(2018-2020,180万),骨干成员
[4]天津市特聘教授科研启动基金(2015-2019,100万),项目负责人
[5]天津市优秀人才基金(2015,30万),项目负责人
[6]国家自然科学基金“聚集型DNA损伤在不同细胞周期中的修复及抑癌机制研究”(2012-2015,60万),项目负责人
[7]天津市科委基金“MRTF-A激活CYP1A1转录调控类固醇激素代谢”(2011-2014,10万),项目负责人
研究领域
[1]DNA损伤修复/基因组稳定性机制
[2]肿瘤、衰老的分子生物学及药理学研究
[3]食品/药品安全检测及体系构建
近期论文
查看导师新发文章
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[1].LiuQ.,ZhangZ.,LiuY.,CuiZ.,ZhangT.,LiZ.,MaW.Cancercellsgrowingonperfused3DcollagenmodelproducedhigherROSlevelandweremoreresistanttocisplatincomparingto2Dmodel.JApplBiomaterFunctMater.2018Jul;16(3):144-150.
[2].ZhangR.,LiH.,ZhangS.,ZhangY.,WangN.,ZhouH.,HeH.,HuG.,ZhangT.,MaW.RXRαprovokestumorsuppressionthroughp53/p21/p16andPI3K-AKTsignalingpathwaysduringstemcelldifferentiationandincancercells.CellDeath&Disease,2018May10;9(5):532.
[3].HeH,DuF,HeY,WeiZ,MengC,XuY,ZhouH,WangN,LuoXG,MaW,ZhangTC.TheWnt-β-cateninsignalingregulatedMRTF-Atranscriptiontoactivatemigration-relatedgenesinhumanbreastcancercells.Oncotarget.2018Jan4;9(20):15239-15251.
[4].HeH,LaiY,HaoY,LiuY,ZhangZ,LiuX,GuoC,ZhangM,ZhouH,WangN,LuoXG,HuoL,MaW,ZhangTC.Selectivep300inhibitorC646inhibitedHPVE6-E7genes,alteredglucosemetabolismandinducedapoptosisincervicalcancercells.EurJPharmacol.2017Oct5;812:206-215.
[5].WangC,LiZ,WangH,QiuH,ZhangM,LiS,LuoX,SongY,ZhouH,MaW,ZhangT.,RapidbiodegradationofaflatoxinB1bymetabolitesofFusariumsp.WCQ3361withbroadworkingtemperaturerangeandexcellentthermostability.JSciFoodAgric,2017Mar1;97(4):1342~1348
[6].HeH,WeiZ,DuF,MengC,ZhengD,LaiY,YaoH,ZhouH,WangN,LuoXG,MaW,ZhangTC.,TranscriptionofHOTAIRisregulatedbyRhoC-MRTF-A-SRFsignalingpathwayinhumanbreastcancercells.,CellularSignalling,2017Feb1;31:87~95
[7].ZhangR,WangN,ZhangLN,HuangN,SongTF,LiZZ,LiM,LuoXG,ZhouH,HeHP,ZhangXY,MaW,ZhangTC,KnockdownofDNMT1andDNMT3aPromotestheAngiogenesisofHumanMesenchymalStemCellsLeadingtoArterialSpecificDifferentiation.,StemCells,2016May;34(5):1273~1283
[8].LiaoXH,ZhengL,HeHP,ZhengDL,WeiZQ,WangN,DongJ,MaW,ZhangTC.STAT3regulatedATRviamicroRNA-383tocontrolDNAdamagetoaffectapoptosisinA431cells.CellSignal.2015Nov;27(11):2285-95.
[9].MaW,WestmorelandJW,andResnickMA.HomologousrecombinationrescuesssDNAgapsgeneratedbyNERandreducedtranslesionDNAsynthesisinG2cells.ProcNatlAcadSciUSA.2013Jul30;110(31):E2895-904.
[10].CovoS,MaW,WestmorelandJW,GordeninDAandResnickMA.UnderstandingtheoriginsofUV-inducedrecombinationthroughmanipulationofsisterchromatidcohesion.CellCycle.2012Nov;11(21)3937-44
[11].MaW,HalwegCJ,MenendezD,ResnickMA.DifferentialeffectsofPARPinhibitionanddepletiononsingle-anddouble-strandbreakrepairinhumancellsarerevealedwithEBV.ProcNatlAcadSciUSA.2012Apr24;109(17):6590-5.
[12].MaW,WestmorelandJW,GordeninDAandResnickMA.Alkylationbasedamageisconvertedintorepairabledouble-strandbreaksandcomplexintermediatesinG2cellslackingAPendonuclease.PLoSGenetics,20117(4):e1002059
[13].WestmorelandJW,MaW,YanY,VanHulleK,MalkovaA,andResnickMA.RAD50(RMX)isessentialforefficientresectionandrecombinationalrepairofradiation-induceddouble-strandbreaksbutnotcrossovers.PLoSGenetics,2009Sep;5(9):e1000656
[14].MaW,PanduriV,SterlingJ,VanHoutenB,GordeninDA,ResnickMA.Thetransitionofclosely-spacedlesionsintodouble-strandbreaksispreventedbyaninteractionbetweenPol32,Rad27/FEN1andPCNA.Mol.CellBiol.2009Mar;29(5):1212-21
[15].MaW,ResnickMAandGordeninDAApn1andApn2endonucleasespreventaccumulationofrepair-associatedDNAbreaksinbuddingyeastasrevealedbydirectchromosomalanalysis.NucleicAcidsResearch.2008Apr;36(6):1836-46
专著章节
[16].MaW(2012)Topoisomerases.EncyclopediaofCancer,EditedbyDr.ManfredSchwab;NewYork:Springer,http://www.springerreference.com/docs/html/chapterdbid/177517.html
[17].MaW(2012)Cellcyclecheckpoints.EncyclopediaofCancer,EditedbyDr.ManfredSchwab;NewYork:Springer,http://www.springerreference.com/docs/html/chapterdbid/172653.html
[18].MaW,WestmorelandJWandResnickMA.(2011)Characterizingresectionatrandomanduniquechromosomedouble-strandbreaksandtelomereends.MethodsinMolecularBiology.Vol.745:15-31