Sintim, Herman O. - University of Maryland - Department of Chemistry & Biochemistry

个人简介

University College London, B.Sc 1999 University of Oxford, PhD 2002 (with David Hodgson) University of Oxford, Post-Doctoral Fellow, 2002-2004 (with Timothy Donohoe) Stanford University, Post-Doctoral Fellow, 2004-2006 (with Eric Kool)

研究领域

The chemical biology of bacterial communication, virulence factors production and biofilm formation (quorum sensing and c-di-GMP signaling in bacteria). The discovery of new antibiotics with novel modes of action. The catalytic cycle of total syntheses of complex bioactive molecules and the discovery of new reaction methodologies. New DNA nanostructures and machines for biotechnological applications such as simple detection of pathogenic genes in clinical samples. New microfluidic devices for sensing and the study of biological processes (collaborative project with NIST scientists).

近期论文

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Bacterial secretions of nonpathogenic E. coli elicit inflammatory pathways: a closer investigation of interkingdom signaling. Amin Zargar, David N. Quan, Karen K. Carter, Min Guo, Herman O. Sintim, Gregory F. Payne and William Bentley mBio, 2015, 6(2):e00025-15. Agents that inhibit bacterial biofilm formation. Nira Rabin, Yue Zheng, Clement Opoku-Temeng, Yixuan Du, Eric Bonsu and Herman O. Sintim* Future Med. Chem. 2015, in press. Biofilm formation mechanisms and targets for developing anti-biofilm agents. Nira Rabin, Yue Zheng, Clement Opoku-Temeng, Yixuan Du, Eric Bonsu and Herman O. Sintim* Future Med. Chem. 2015, in press. Unraveling curcumin degradation: Autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione. Odaine N. Gordon, Paula B. Luis, Herman O. Sintim and Claus Schneider J. Biol. Chem. 2015, 290, 4817-4828. Geminal dihalogen isosteric replacement in hydrated AI-2 affords potent quorum sensing modulators. Min Guo, Yue Zheng, Jessica Terrell, Michal Ad, Clement Opoku-Temeng, William E. Bentley and Herman O. Simtim* Chem. Commun. 2015, 51, 2617-2620. Rapid nucleic acid melting analyses using a microfabricated electrochemical platform. Zuliang Shen, Herman O. Sintim* and Steve Semancik* Anal. Chim. Acta, 2015, 853, 265-270. Molecular Insights into How Ligands Activate or Inactivate LasR. Yue Zheng and Herman O. Sintim* Chem. Biol. 2014, 1261-1263. Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay Yue Zheng, Jie Zhou, David Sayre and Herman O. Sintim* Chem. Commun. 2014, 50, 11234-11237. Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding. Jie Zhou, Vu Le, Dimpy Kalia, Shizuka Nakayama, Clinton Mikek, Edwin A. Lewis and Herman O. Sintim Mol. BioSyst. 2014, 10, 2724-2734. STING ligand c-di-GMP improves cancervaccination against metastatic breast cancer Dinesh Chandra, Wilber Quispe-Tintaya, Arthee Jahangir, Denise Asafu-Adjei, IIyssa Ramos, Herman O. Sintim, Jie Zhou, Yoshihiro Hayakawa, David K. R. Karaolis and Claudia Gravekamp Cancer Immunol. Res. 2014, doi: 10.1158/2326-6066.CIR-13-0123 Convenient detection of HPV virus in clinical sample using concurrent rolling circle and junction probe amplifications. Lei Yan, Kailong Liu and Herman O. Sintim* Chem. Commun. 2014, 50, 7147-7149.