路福平 - 天津科技大学 - 生物工程学院

个人简介

路福平，男，工学博士，教授，博士研究生导师，天津科技大学校长，食品营养与安全国家重点实验室主任，工业发酵微生物教育部重点实验室主任，国家百千万人才工程人选，国家有突出贡献中青年专家，天津市“131”人才第一层次，享受政府特贴专家。现任中国食品科学技术学会副理事长、中国微生物学会理事

研究领域

围绕工业生物催化工程的研究领域，开展四个方向的研究工作： [1] 酶制剂的开发与应用：酶分子的挖掘与进化，酶蛋白的创制与发酵过程控制，酶制剂的制备与应用。 [2] 重要工业菌株的遗传改造：以功能产品合成为目标，对重要微生物进行遗传分析与基因组改造，构建目标产品高效合成的细胞工厂。 [3] 甾体激素类药物的生物转化：选育和构建高效生物转化菌株，构建甾体类药物的高效生物转化平台。 [4] 益生菌筛选与功能食品的开发：围绕益生菌及益生菌产品进行研究，实现在食品、饲料和药物方面的应用。

近期论文

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Sun DY, Liu X, Zhu ML, Chen Y, Li C, Cheng XT, Zhu ZL, Lu FP*, Qin HM*. Efficient biosynthesis of high-value succinic acid and 5-hydroxyleucine using a multienzyme cascade and whole-cell catalysis[J]. Journal of Agricultural and Food Chemistry, 2019, 67:12502-12510. Jia LG, Wang Y, Sang JC, Cui W, Zhao WP, Wei W, Chen BB, Lu FP*, Liu FF*. Dihydromyricetin inhibits α‑synuclein aggregation, disrupts preformed fibrils, and protects neuronal cells in culture against amyloid-induced cytotoxicity[J]. Journal of Agricultural and Food Chemistry, 2019, 67:3946-3955. Liu YH*, Huang L, Zheng D, Xu ZH, Li YZ, Shao SL, Zhang YF, Ge XQ, Lu FP*. Biochemical characterization of a novel GH43 family β-xylosidase from Bacillus pumilus[J]. Food Chemistry, 2019, 295:653-661. Liu YH*, Huang L, Fu Y, Zheng D, Ma JY, Li YZ, Xu ZH, Lu FP*. A novel process for phosphatidylserine production using a Pichia pastoris whole-cell biocatalyst with overexpression of phospholipase D from Streptomyces halstedii in a purely aqueous system[J]. Food Chemistry, 2019, 274:535-542. Liu YH, Huang L, Zheng D, Fu Y, Shan MY, Li YZ, Xu ZH, Jia LB, Wang WH*, Lu FP*. Characterization of transglutaminase from Bacillus subtilis and its cross-linking function with a bovine serum albumin model[J]. Food & Function, 2018, 9(11):5560-5568. Liu YH, Liu YX, Xu ZH, Shan MY, Ge XQ, Zhang YF, Shao SL, Huang L, Wang WH*, Lu FP*. Effects of Bacillus subtilis transglutaminase treatment on the functional properties of whey protein[J]. LWT-Food Science and Technology, 2019, 116:108559. Sun DY, Gao DK, Liu X, Zhu ML, Li C, Chen Y, Zhu ZL, Lu FP*, Qin HM*. Redesign and engineering of a dioxygenase targeting biocatalytic synthesis of 5-hydroxyl leucine[J]. Catalysis Science & Technology, 2019, 9:1825-1834. Peng C, Shi CS, Cao X, Li Y, Liu FF, Lu FP*. Factors influencing recombinant protein secretion efficiency in gram-positive bacteria: signal peptide and beyond[J]. Frontiers in Bioengineering and Biotechnology, 2019, 7:139. Wang HB, Huang L, Li YZ, Ma JY, Wang S, Zhang YF, Ge XQ, Wang N, Lu FP*, Liu YH*. Characterization and application of a novel laccase derived from Bacillus amyloliquefaciens[J]. International Journal of Biological Macromolecules, 2020, 150:982-990. Liu YH, Shi CS, Li DK, Chen XJ, Li JL, Zhang YW, Yuan H, Li Y*, Lu FP*. Engineering a highly efficient expression system to produce BcaPRO protease in Bacillus subtilis by an optimized promoter and signal peptide[J]. International Journal of Biological Macromolecules, 2019, 138:903-911. Zhou CX, Liu H, Yuan FY, Chai HN, Wang HK, Liu FF, Li Y, Zhang HT*, Lu FP*. Development and application of a CRISPR/Cas9 system for Bacillus licheniformis genome editing[J]. International Journal of Biological Macromolecules, 2019, 122:329-337. Qin HM1, Gao DK1, Zhu ML, Li C, Zhu ZL, Wang HB, Liu WD*, Tanokura M*, Lu FP*. Biochemical characterization and structural analysis of ulvan lyase from marine Alteromonas sp. reveals the basis for its salt tolerance[J]. International Journal of Biological Macromolecules, 2020, 147:1309-1317. Zhang HT1, Sang JC1, Zhang Y1, Sun TW, Liu H, Yue R, Zhang J, Wang HK, Dai YJ, Lu FP*, Liu FF*. Rational design of a Yarrowia lipolytica derived lipase for improved thermostability[J]. International Journal of Biological Macromolecules, 2019, 137:1190-1198. Zhou CX, Zhou HY, Li DK, Zhang HT*, Wang HB, Lu FP*. Optimized expression and enhanced production of alkaline protease by genetically modified Bacillus licheniformis 2709[J]. Microbial Cell Factories, 2020, 19:45. Zhou CX, Zhou HY, Zhang HT*, Lu FP*. Optimization of alkaline protease production by rational deletion of sporulation related genes in Bacillus licheniformis[J]. Microbial Cell Factories, 2019, 18:127. Qi ZL, Zhu ZL, Wang JW, Li ST, Guo QQ, Xu PP, Lu FP*, Qin HM*. Biochemical analysis and the preliminary crystallographic characterization of dtagatose 3epimerase from Rhodobacter sphaeroides[J]. Microbial Cell Factories, 2017, 16:193. Zhu ZL, Gao DK, Li C, Chen Y, Zhu ML, Liu X, Tanokura, M*, Qin HM*, Lu FP*. Redesign of a novel d-allulose 3-epimerase from Staphylococcus aureus for thermostability and efficient biocatalytic production of d-allulose[J]. Microbial Cell Factories, 2019, 18:59. Mao SH1, Wang JW1, Liu FF1, Zhu ZL, Gao DK, Guo QQ, Xu PP, Ma Z, Hou YL, Cheng XT, Sun DY, Lu FP*, Qin HM*. Engineering of 3ketosteroidΔ1dehydrogenase based sitedirected saturation mutagenesis for efficient biotransformation of steroidal substrates[J]. Microbial Cell Factories, 2018, 17:141.