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个人简介

张同存,男,博士,教授,博士生导师。天津市特聘教授,天津市政协委员。兼任工业生物技术教育部重点实验室(江南大学)学术委员会委员,天津市蛋白质科学重点实验室(南开大学)学术委员会委员,中国发酵工业协会多元醇分会理事,中国生化与分子生物学会理事,天津市微生物学会理事,天津市细胞生物学学会理事,美国癌症学会高级会员,美国心脏病学会会员,中国保健品学会特聘专家。 科研情况 [1]国家自然科学基金:Stat3抑制myocardin诱导心肌肥厚的机制研究,80万,2013-2016 [2]863计划:食品微生物基因组改造(益生菌功能基因分析及安全性、功能评价),215万,2012-2015 [3]863计划:天然多糖的制备与功能多糖的研制,58万,2012-2015 [4]天津市应用基础与前沿技术研究计划:L.caseiHZ1新型降压肽的鉴定及其分子育种研究,2014-2017 [5]国家自然科学基金:Myocardin与雌激素受体协同诱导血管平滑肌细胞分化及机制研究,2009-2012 [6]国家自然科学基金:Myocarin诱导心肌肥厚及其机制的研究,2007-2009 [7]863计划:益生菌定向筛选与功能开发关键技术的研究,2008-2010 [8]973计划:表观遗传学的结构机理研究(课题4-表观遗传调控过程中重要蛋白的结构与功能研究),2009-2014 [9]高等学校博士学科点专项科研基金:MRTF-A促进雌激素代谢及机制研究,2012-2014 [10]天津市科委应用基础及前沿技术研究计划项目:Myocardin家族相关转录因子和SRC-1相互作用及在药物代谢中的作用,2007-2009 [11]天津市东丽区科技创新专项:重组猪转移因子rTF的研究及产业化,2011-2012 [12]天津科技大学海河学者启动基金:Myocardin在动脉硬化发病中的作用及机制研究,2008-2010 [13]横向项目:D-塔格糖乳酸菌生物转化生产体系的建立,2013-2014 [14]横向项目:谷氨酸棒杆菌生产核苷酸发酵条件优化,2012-2013获奖情况 先后荣获天津市科协2012年度先进学会工作者、2012年天津科技大学优秀硕士论文、2013年天津市优秀硕士论文、2014年天津科技大学优秀硕士论文等奖励。

研究领域

[1]心血管疾病和肿瘤等重大疾病转录调节异常的分子机制和相关新药开发等研究 [2]益生菌及工业微生物的功能基因与转录调控机制研究 [3]肠道微生态与健康调控及机制研究

近期论文

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[1]XingWJ,LiaoXH,WangN,ZhaoDW,ZhengL,ZhengL,DongJ,ZhangTC*.MRTF-AandSTAT3promoteMDA-MB-231cellmigrationviahypermethylatingBRSM1.IUBMBLife.2015Apr9.(IF2.755) [2]LiXM,LuoXG,WangN,ZhouH,SiCL,LiK,MaN,ZhangTC*.TheextractofHypericumascyronL.inducesbacterialcelldeaththroughapoptosispathway.JEthnopharmacol.2015May26;166:205-210.(IF2.939) [3]LiXM,LuoXG,ZhangCZ,WangN,ZhangTC*.QualityevaluationofHypericumascyronextractbytwo-dimensionalhigh-performanceliquidchromatographycoupledwiththecolorimetric3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromidemethod.JSepSci.2015,38(4):576-584.(IF2.594) [4]RuiZhang,NanWang,ManZhang,Li-NanZhang,Zhi-XiaGuo,Xue-GangLuo,HaoZhou,Hong-PengHe,ZhangTC*.Rho/MRTF-A-InducedIntegrinExpressionRegulatesAngiogenesisinDifferentiatedMultipotentMesenchymalStemCells.StemCellsInternational.2015.(IF2.806) [5]LiM,WangN,GongHQ,LiWZ,LiaoXH,YangXL,HeHP,CaoDS,ZhangTC*.Ca²⁺signal-inducedcardiomyocytehypertrophythroughactivationofmyocardin.GENE.2015.15;557(1):43-51.(IF2.082) [6]LiXM*,LuoXG*#,SiCL,WangN,ZhouH,HeJF,ZhangTC#.AntibacterialactivecompoundsfromHypericumascyronL.inducebacterialcelldeaththroughapoptosispathway.EurJMedChem.2015,96:436-444.(*Co-firstauthorwithstudent;#Co-correspondingauthors)(IF3.432) [7]Xiang-ZhuShu,Li-NanZhang,RuiZhang,Cai-JiaoZhang,Hong-PengHe,HaoZhou,NanWang,ZhangTC*.Histoneacetyltransferasep300promotesMRTF-A-mediatestransactivationofVE-cadheringeneinhumanumbilicalveinendothelialcells.GENE.2015May25;563(1):17-23.(IF2.082) [8]Ruo-LeiJian,Li-BinMao,YaoXu,Xiao-FanLi,Feng-PoWang,Xue-GangLuo,HaoZhou,Hong-PengHe,NanWang,ZhangTC*.Generationofinsulin-producingcellsfromC3H10T1/2mesenchymalprogenitorcells.GENE.2015May10;562(1):107-16.(IF2.082) [9]Xing-HuaLiao,NanWang,Dong-WeiZhao,De-LiangZheng,LiZheng,Wen-JingXing,HaoZhou,Dong-SunCao,ZhangTC*.NF-κB(p65)negativelyregulatesmyocardin-inducedcardiomyocytehypertrophythroughmultiplemechanisms.CellularSignalling.2014,26(12),2738-2748.(IF4.471) [10]HeH,LiuX,WangD,WangY,LiuL,ZhouH,LuoX,WangN,JiB,LuoY,ZhangTC*.SAHAinhibitsthetranscriptioninitiationofHPV18E6/E7genesinHeLacervicalcancercells.GENE.2014,553(2):98-104.(IF2.19) [11]Xing-HuaLiao,NanWang,Long-YueLiu,LiZheng,Wen-JingXing,Dong-WeiZhao,Xue-GuangSun,PengHu,JianDong,ZhangTC*.MRTF-AandSTAT3synergisticallypromotebreastcancercellmigration.CellularSignalling.2014,26(11):2370-2380.(IF4.471) [12]Xing-HuaLiao,Yan-QiLi,NanWang,LiZheng,Wen-JingXing,Dong-WeiZhao,Ting-BaoYan,YueWang,Long-YueLiu,Xue-GuangSun,PengHu,HaoZhou,ZhangTC*.Re-expressionandepigeneticmodificationofmaspininducedapoptosisinMCF-7cellsmediatedbymyocardin.CellularSignalling.2014,26(6):1335-1346.(IF4.304) [13]GuXC,LuoXG,WangCX,MaDY,WangY,HeYY,LiW,ZhouH,ZhangTC*.CloningandanalysisofBileSaltHydrolaseGenesfromLactobacillusplantarumTH1CGMCCNo.8198.BiotechnolLett.2014,36(5):975-983.(IF1.853) [14]Xing-HuaLiao,YueWang,NanWang,Ting-BaoYan,Wen-JingXing,LiZheng,Dong-WeiZhao,Yan-QiLi,Long-YueLiu,Xue-GuangSun,PengHu,ZhangTC*.Humanchorionicgonadotropin(hCG)decreaseshumanbreastcancercellproliferationandpromotesdifferentiation.IUBMBLife.2014,66(5):352-360.(IF2.789) [15]LuoXG,ZhangCL,ZhaoWW,LiuZP,LiuL,MuA,GuoS,WangN,ZhouH,ZhangTC*.HistonemethyltransferaseSMYD3promotesMRTF-A-mediatedtransactivationofMYL9andmigrationofMCF-7breastcancercells.CancerLett.2014,344(1):129-137.(IF4.238) [16]LiXM,LuoXG,MaN,LiK,LiW,MaDY,ZhangTC*.QualityandantitumouractivityevaluationofextractofHypericumascyron.BiomedChromatogr.2014,36(5):975-984.(IF1.966) [17]Xing–HuaLiao,Da–LinLu,NanWang,Long–YueLiu,YueWang,Yan–QiLi,Ting–BaoYan,Xue–GuangSun,PengHuandZhangTC*.EstrogenreceptoramediatesproliferationofbreastcancerMCF–7cellsviaap21/PCNA/E2F1-dependentpathway.TheFEBSjournal.2014,281(3):927-42.(IF4.25) [18]ZhipengLiu,XuegangLuo,LeiLiu,WenwenZhao,ShuGuo,YuGuo,NanWang,HongpengHe,XinghuaLiao,WenjianMa,HaoZhou,ZhangTC*.Histoneacetyltransferasep300promotesMegakaryoblasticleukemia1-mediatedtransactivationofcatechol-O-methyltransferase.ActaBiochBiophSin.2013,45(12):1002-1010.(IF1.807) [19]ChunlingZhang,XuegangLuo,LeiLiu,ShuGuo,WenwenZhao,AiMu,HaoZhou,NanWang,ZhangTC*.MRTF-Aisupregulatedby17β-estradiolandpromotesmigrationofMCF-7breastcancercellsviatransactivationofMYL9andCYR61.ActaBiochBiophSin.2013,45(11):921-927.(IF1.807) [20]NanWang,RuiZhang,Shui-JingWang,Chun-LingZhang,Li-BinMao,Chun-YuZhuang,Yan-YangTang,Xue-GangLuo,HaoZhou,ZhangTC*.VascularendothelialgrowthfactorstimulatesendothelialdifferentiationrommesenchymalstemcellsviaRho/myocardin-relatedtranscriptionactor-Asignalingpathway.TheInternationalJournalofBiochemistry&CellBiology.2013,45(7):1447-1456.(IF4.634) [21]NanWang,YaoXu,TaoQin,Feng-PoWang,Lin-LinMa,Xue-GangLuo,ZhangTC*.Myocardin-relatedtranscriptionfactor-Aisakeyregulatorinretinoicacid-inducedneural-likedifferentiationofadultbonemarrow-derivedmesenchymalstemcells.Gene.2013,523(2):178-186.(IF2.341) [22]FengLin,NanWang,ZhangTC*.Theroleofendothelial-mesenchymaltransitionindevelopmentandpathologicalprocess.IUBMBLife.2012,64(9):717-723.(IF4.514) [23]NanWang,Guang-DaRen,ZhenZhou,YaoXu,TaoQin,Ru-FaYu,ZhangTC*.CooperationofMyocardinandSmad2inInducingDifferentiationofMesenchymalStemCellsintoSmoothMuscleCells.IUBMBLife.2012,64(4):331-339.(IF3.514) [24]JiaoLu,JinleiTang,YiLiu,XinnaZhu,ZhangTC*,XueliZhang.CombinatorialmodulationofgalPandglkgeneexpressionforimprovedalternativeglucoseutilization.ApplMicrobiolBiotechnol.2012,93(6):2455-2462.(IF3.425) [25]LuoXG,TianWJ,NiM,JingXL,LvLH,WangN,JiangY,ZhangTC*.Solubleexpressionofactiverecombinanthumantissueplasminogenactivatorderivative(K2S)inEscherichiacoli.PharmBiol.2011,49(6):653-657.(IF0.878) [26]LiaoXH,WangN,LiuQX,QinT,CaoB,CaoDS,ZhangTC*.Myocardin-RelatedTranscriptionFactor-AInducesCardiomyocyteHypertrophy.IUBMBLife.2011,63(1):54-61.(IF3.514) [27]J.Wang,ZhangTC*andX.Liu.PreliminarycrystallographicanalysisoftheN-terminaldomainofFILIA,aproteinessentialforembryogenesis.crystallizationcommunications.2010,66(9):1111-1114.(IF0.563) [28]Xiao-LanJing,Xue-GangLuo,Wen-JingTian,Li-HuiLv,YongJiang,NanWang,ZhangTC*.High-LevelExpressionoftheAntimicrobialPeptidePlectasininEscherichiacoli.CurrMicrobiol.2010,61(3):197-202.(IF1.51) [29]Xue-GangLuo,TaoXi,ShuGuo,Zhi-PengLiu,NanWang,YongJiangandZhangTC*.EffectsofSMYD3overexpressionontransformation,serumdependence,andapoptosissensitivityinNIH3T3cells.IUBMBLife.2009,61(6):679-684.(IF3.578) [30]NanWang,ZhenZhou,XinghuaLiaoandZhangTC*.RoleofmicroRNAsincardiachypertrophyandheartfailure.IUBMBLife.2009,61(6):566-571.(IF3.578) [31]XinW*,ZhangTC*,CaoD,WangZ,AntosCL,LiS,WangY,OlsonEN,WangDZ.,Myocardininducescardiachypertrophy.CircRes.2006Apr28;98(8):1089-97(IF9.8)(*Co-firstauthor). [32]FaucetteS*,ZhangTC*,MooreR,SueyoshiT,OmiecinskiC,LecluyseE,NegishiM,WangH,RelativeActivationofHumanPregnaneXReceptorversusConstitutiveAndrostaneReceptorDefinesDistinctClassesofCYP2B6andCYP3A4Inducers.JPharmacolExpTher.2006Oct13(IF4.908)(*Co-firstauthor). [33]WangH,FaucetteS,ZhangTC,etal,ValidationofahumanCARvariant(hCAR3)astheinvitropredictorforPXRindependentCYP2B6/CYP3A4inductionDugMetaRev.38:115,179,2006.(IF5.135).

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