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个人简介

肖冬光,教授,博士生导师,天津市教学团队-发酵工程教学团队负责人,政府特贴专家。中国能源学会副理事长,中国发酵工业协会常务理事,中国发酵协会酵母分会副理事长,全国发酵工程技术工作委员会委员,全国酿酒标准化技术委员会委员,《酿酒科技》杂志编委会主任,《中国酿造》杂志编委,《中国啤酒》杂志编委。长期从事发酵工程方面的教学与科研,主要研究方向为食品发酵与酿造。主编的教材和专著有《酿酒活性干酵母的生产与应用技术》、《微生物工程原理》、《白洒生产技术》等,发表论文300余篇,其中SCI和EI收录40余篇,申请专利40余项,获得授权国家发明专利20余项。近期承担的主要科研项目 [1]肖冬光,张翠英,等。酿酒酵母酯醇代谢机理的研究与工业菌种的定向改造,国家自然科学基金项目,86万元,2015-2018年,项目编号:31471724。 [2]肖冬光,张翠英,等。面包酵母海藻糖代谢机制与耐冷冻机理的研究,国家自然科学基金项目,60万元,2012-2015年,项目编号:31171730。 [3]肖冬光,张翠英,等。食品微生物基因组改造-白酒微生物基因组改造,国家863计划子课题,65万,2012-2015年,项目编号:2012AA022108。 [4]肖冬光,张翠英,等。大宗食品发酵安全低碳加工关键技术研究-新型活性干酵母的开发,国家863计划子课题,50万,2013-2017年,项目编号:2013AA102106-08。 [5]肖冬光,张翠英,等。一株改良酿酒酵母在扳倒井白酒生产中的应用,山东扳倒井股份有限公司,10万,2014-2015年,项目编号:1400040006。主要专利情况 1ZL200710150861.8酵母菌混合发酵乳清生产燃料乙醇的方法 2ZL200410018684.4益生乳酸菌发酵剂的制备方法及其在新鲜干酪中的应用 3ZL200410019478.5检验牛乳中抗生素残留量的微生物制剂制备方法及其应用 4ZL200410094105.4提高淀粉质原料酒精浓醪发酵酒精度的方法 5ZL200510014273.2提高面包酵母菌体耐冷冻性的处理方法 6ZL200810153108.9高耐性酿酒酵母工程菌及其构建方法 7ZL03129701.3两步发酵法生产酵母胞外海藻糖的方法 8ZL201010227788.1低产高级醇酿酒酵母工程菌及其构建方法 9ZL200910228690.5一种玫瑰香葡萄酒专用酿酒酵母及其在葡萄酒酿造中的应用 10ZL200910071096.X用纤维物质生产燃料乙醇和2,3-丁二醇的方法 11ZL201310153755.0,一种适合于冷冻面团发酵的耐冷冻活性干酵母 12ZL201010299111.9,利用玉米皮生产单细胞蛋白和L-阿拉伯糖的方法 13ZL201010503159.7一株镉盐抗性热带假丝酵母及其应用 14ZL201010503178.X一株镉盐抗性面包酵母及其应用 15ZL201110094875.9一种高产酯酿酒酵母基因工程菌及其构建方法 16ZL201110294810.9一种利用酒尾提高清香型白酒中酯香物质的方法 17ZL201210080040.2一株含有Lg-ATF1基因的酯酿酒酵母工程菌 18ZL201210080232.3一株高效利用乳糖生产燃料乙醇的酿酒酵母工程菌 19ZL201210080231.9一株高产乙酸酯酿酒酵母工程菌 20ZL201210134936.4一种利用玉米芯残渣同步糖化发酵生产2,3-丁二醇的方法 获奖情况 作为第一及主要完成人先后获得“国家科技进步二等奖一项,国家科技进步奖三等奖一项”,“中国轻工业联合会科技进步二等奖”一项,“中国食品学会科学技术创新一等奖”一项,“天津市科技进步三等奖”一项。

研究领域

Ⅰ.利用现代生物技术改造传统酿造工业:主要通过酿造微生物功能基因和关键酶系的确定与定向进化、微量代谢物质的调节与控制,提高酿造菌种的生产性能和酿造产品的品质,促进我国传统酿造工业模式的改革,提升酿造行业的生产技术水平。 Ⅱ.环境生物技术:主要包括清洁生产工艺、发酵原料综合利用、发酵副产品高值化开发和发酵废弃物的资源化处理等。 Ⅲ.微生物资源的开发与利用:主要包括生物质资源生产燃料乙醇、单细胞蛋白和生物质化学品,以及活性干酵母、生理活性物质等新型生物产品的研究与开发等。在酿酒活性干酵母、浓醪发酵生产燃料乙醇和用现代生物技术改造传统酿造工业的研究方面,具国际先进水平。

近期论文

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[1]MaLJ,CuiYZ,CaiR,LiuXQ,ZhangCY,XiaoDG.Optimizationandevaluationofalkalinepotassiumpermanganatepretreatmentofcorncob.BioresourceTechnology,2015,180:1-6. [2]Cui-YingZhang*#,XueLin#,Hai-YanSong,Dong-GuangXiao.EffectsofMAL61andMAL62overexpressiononmaltosefermentationofbaker"syeastinleandough.WorldJMicrobiolBiotechnol.2015May24.[Epubaheadofprint] [3]Cui-YingZhang*,Ya-NanQi,Hong-XiaMa,WeiLi,Long-HaiDai,Dong-guangXiao.DecreasedproductionofhigheralcoholsbySaccharomycescerevisiaeforChinesericewinefermentationbydeletionofBataminotransferases.JIndMicrobiolBiotechnol.2015,42(4):617-625. [4]GuoX,GuanX,WangY,LiL,WuD,ChenY,PeiH,XiaoD.ReductionofbiogenicaminesproductionbyeliminatingthePEP4geneinSaccharomycescerevisiaeduringfermentationofChinesericewine.FoodChem.2015,178:208-211. [5]XueLin,Cui-YingZhang*,Xiao-WenBai,Dong-GuangXiao*.Enhancedleaveningabilityofbaker"syeastbyoverexpressionofSNR84withPGM2deletion.JIndMicrobiolBiotechnol.2015,42(6):939-948. [6]XueLin,Cui-YingZhang*,Xiao-WenBai,BingFeng,Dong-GuangXiao*.Improvementofstresstoleranceandleaveningabilityundermultiplebaking-associatedstressconditionsbyoverexpressionoftheSNR84geneinbaker"syeast.IntJFoodMicrobiol.2015;197C:15-21.(SCI2区,IF:3.155) [7]XueLin,Cui-YingZhang*,Xiao-WenBai,Hai-YanSongandDong-GuangXiao*.EffectsofMIG1,TUP1andSSN6deletiononmaltosemetabolismandleaveningabilityofbaker’syeastinleandough.MicrobialCellFactories2014,13:93. [8]Cui-YingZhang,Xiao-PeiPeng,WeiLi,Xue-WuGuo,Dong-GuangXiao.Optimizationof2,3-butanediolproductionbyEnterobactercloacaeinsimultaneoussaccharificationandfermentationofcorncobresidue.BiotechnologyandAppliedBiochemistry.2014,61(5):501-509. [9]YefuCHEN*,XinxinZHANG,ShijieZHANG,WeijunQIN,ChanghuiGUO,XuewuGUO,DongguangXIAO.Enhancedenzymaticxylose/cellulosefractionationfromalkalineliquor-pretreatedcorncobbysurfactantadditionandseparatefermentationtobioethanol.TurkishJournalofBiology.2014,38(4):478-484. [10]YefuChen*,JianGuo,FengLi,MingmingLiu,XinxinZhang,XuewuGuo,DongguangXiao.ProductionofpullulanfromxyloseandhemicelluloseshydrolysatebyAureobasidiumpullulansAY82withpHcontrolandDL-dithiothreitoladdition.BiotechnologyandBioprocessEngineering.2014,19(2):282-288. [11]YefuChen*,FengLi,JianGuo,GuangxinLiu,XuewuGuo,DongguangXiao.EnhancedethylcaproateproductionofChineseliquoryeastbyoverexpressingEHT1withdeletedFAA1.JournalofIndustrialMicrobiologyandBiotechnology.2014,41(3):563-572. [12]LipingDu,JianxunLi,WeiLi,YunfeiLi,TaoLi,DongguangXiao,Characterizationofvolatilecompoundsofpu-erhteausingsolid-phasemicroextractionandsimultaneousdistillation–extractioncoupledwithgaschromatography–massspectrometry,FoodResearchInternational,2014,57:61-70 [13]GuoX,CaoC,WangY,LiC,WuM,ChenY,ZhangC,PeiH,XiaoD.Effectoftheinactivationoflactatedehydrogenase,ethanoldehydrogenase,andphosphotransacetylaseon2,3-butanediolproductioninKlebsiellapneumoniaestrain.BiotechnolBiofuels.2014,7(1):44 [14]GuoXW,ZhangYH,CaoCH,ShenT,WuMY,ChenYF,ZhangCY,XiaoDG.Enhancedproductionof2,3-butanediolbyoverexpressingacetolactatesynthaseandacetoinreductaseinKlebsiellapneumoniae.BiotechnologyAppliedBiochemistry2014;61(6):707-715 [15]DongJ,XuH,ZhaoL,ChenY,ZhangC,GuoX,HouX,ChenD,ZhangC,XiaoD.EnhancedacetateesterproductionofChineseliquoryeastbyoverexpressingATF1throughpreciseandseamlessinsertionofPGK1promoter.JIndMicrobiolBiotechnol.2014,41(12):1823-1828. [16]Bo-YuDong,Ye-FuChen*,Chang-ChunZhao,Shi-JieZhang,Xue-WuGuo,andDong-GuangXiao,SimultaneousDeterminationofFurfural,AceticAcid,and5-HydroxymethylfurfuralinCorncobHydrolysatesUsingLiquidChromatographywithUltravioletDetection.JournalofAOACInternational.2013,96(6):1239-1244. [17]DeguangWu,XuewuGuo,JunLu,XiSun,FengLi,YefuChen,DongguangXiao.Arapidandefficientone-stepsite-directeddeletion,insertion,andsubstitutionmutagenesisprotocol.AnalyticalBiochemistry.2013,434(2):254-8 [18]LipingDu,ChaoWang,,JianxunLi,,DongguangXiao,*,,ChangwenLi,,andYongquanXu,OptimizationofHeadspaceSolid-PhaseMicroextractionCoupledwithGasChromatography–MassSpectrometryforDetectingMethoxyphenolicCompoundsinPu-erhTea,JournalofAgriculturalandFoodChemistry,2013,61(3):561-8. [19]Cui-YingZhang,Yu-LanLiu,Ya-NanQi,Jian-WeiZhang,Long-HaiDai,XueLin,Dong-GuangXiao.Increasedestersanddecreasedhigheralcoholsproductionbyengineeredbrewer"syeaststrains.EuropeanFoodResearchandTechnology,2013,236:1009–1014 [20]JingZou,XuewuGuo,TongShen,JianDong,CuiyingZhang,DongguangXiao,Constructionoflactose-consumingSaccharomycescerevisiaeforlactosefermentationintoethanolfuel,JIndMicrobiolBiotechnol,2013,40:353–363 [21]XuewuGuo,RuishengWang,YefuChen,DongguangXiao,Intergenericyeastfusantswithefficientethanolproductionfromcheesewheypowdersolution:ConstructionofaKluyveromycesmarxianusandSaccharomycescerevisiaeAY-5hybrid,Eng.LifeSci.,2012,12(6):656–661. [22]XiSun,CuiyingZhang,JianDong,MingyueWu,YanZhang,DongguangXiao.Enhancedleaveningpropertiesofbaker’syeastoverexpressingMAL62withdeletionofMIG1inleandough.JIndMicrobiolBiotechnol.2012,39(10):1533-1539. [23]JunLu,JianDong,DeguangWu,YefuChen,XuewuGuo,YuShi,XiSun,DongguangXiao.Constructionofrecombinantindustrialbrewer’syeastwithlowerdiacetylproductionandproteinaseAactivity.EuropeanFoodResearchandTechnology.2012,235(5):951-961. [24]Jian-WeiZhang,Cui-YingZhang,Long-haiDai,JianDong,Yu-LanLiu,Xue-wuGuo,Dong-GuangXiao.Effectsofoverexpressionofthealcoholacetyltransferase-encodinggeneATF1anddisruptionoftheesterase-encodinggeneIAH1ontheflavourprofilesofChineseyellowricewine.InternationalJournalofFoodScience&Technology.2012,47(12):2590-2596. [25]JianLi,YanWang,Cui-yingZhang,Wen-yanZhang,De-mingJiang,Zhi-hongWu,HongLiu,Yue-zhongLi.MyxococcusxanthusviabilitydependsonGroELsuppliedbyeitheroftwogenes,buttheparalogshavedifferentfunctionsduringheatshock,predation,anddevelopment.JournalofBacteriology.2010,192(7):1875-1881. [26]YefuChen*,Xuyang,ShijieZhang,XiaoqiongWang,ChanghuiGuo,XuewuGuo,DongguangXiao.DevelopmentofSaccharomycescerevisiaeproducinghigherlevelsofsulfurdioxideandglutathionetoimprovebeerflavorstability.AppliedBiochemistryandBiotechnology.2012,166(2):402-413. [27]YefuChen*,BoyuDong,WeijunQin,DongguangXiao.Xyloseandcellulosefractionationfromcorncobwiththreedifferentstrategiesandseparatefermentationofthemtobioethanol.BioresourceTechnology.2010,101(18):7005-7010. [28]XiaoD,WuS,ZhuX,ChenY,GuoX.Effectsofsoyafattyacidsoncassavaethanolfermentation.AppliedBiochemistryandBiotechnology.2010,160(2):410-20. [29]XinHao,Dong-GuangXiao,Cui-YingZhang,Ye-FuChen.InfluenceofnutrientsonproteinaseAactivityindraftbeerduringfermentation.InternationalJournalofFoodScienceandTechnology.2010,45(6):1169-1174. [30]XuewuGuo,JunZhou,DongguangXiao.ImprovedethanolproductionbymixedimmobilizedcellsofKluyveromycesmarxianusandSaccharomycescerevisiaefromcheesewheypowdersolutionfermentation.ApplBiochemBiotechnol,2010,160(2):532-538. [31]TianXiaoJIANG,DongGuangXIAO,QiangGAO.Characterisationofmaltosemetabolisminleandoughbylaggingandnon-laggingbaker’syeaststrains,AnnalsofMicrobiology,2008,58(4)655-660

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