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个人简介

张友玉,博士,二级教授,博士生导师。主要从事化学生物学及纳米分析化学等领域的研究。主持国家自然科学基金面上项目5项,国家基金重点项目协作项目1项,省部级重点及一般项目10余项。以第一作者和通讯作者在Angew. Chem. Int. Ed., Anal. Chem., Chem. Commun.等国际著名刊物上发表高水平研究论文200余篇,获国家授权发明专利7项。获湖南省自然科学奖二等奖1项,湖南省科学技术进步奖二等奖1项,中国分析测试学会科学技术奖(CAIA奖)二等奖1项。获2018年湖南师范大学芙蓉百岗明星称号。 主持课题(部分) 1. 国家自然科学基金(21874042), 癌细胞外泌体的生物分析新方法与临床样品检测研究。在研 2. 国家自然科学基金(21475043), Ⅳ族元素量子点的电化学制备及其在生物分析中的应用 3. 国家自然科学基金(21275051), 基于上转换纳米编码探针的多种肿瘤标志物同时检测技术 4. 国家自然科学基金(20975037), 基于功能化蛋白核壳纳米编码信标的核酸适体阵列传感技术研究 5. 国家自然科学基金(20675030), 基于纳米颗粒编码的DNA单碱基突变检测技术研究 6. 国家自然科学基金协作项目(21327806),生物荧光探针的合成与表征

研究领域

主要从事化学生物学及纳米分析化学等领域的研究

近期论文

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Feng Chen,Qiujun Lu,Linna Huang,Biwu Liu,Meiling Liu,Youyu Zhang*,Juewen Liu*, DNA Triplex and Quadruplex Assembled Nanosensors for Correlating K+ and pH in Lysosomes. Angewandte Chemie International Edition, 2020.(DOI:10.1002/anie.202013302) Jianhui Deng,Qiujun Lu,Yuxin Hou,Meiling Liu*,Haitao Li,Youyu Zhang*,Shouzhuo Yao, Nanosensor Composed of Nitrogen-Doped Carbon Dots and Gold Nanoparticles for Highly Selective Detection of Cysteine with Multiple Signals. Analytical Chemistry, 2015 87,(4),2195-2203. Xiaojiao Chen,Yangzhong Wang,Youyu Zhang*,Zhuhai Chen,Yang Liu*,Zhaolong Li,Jinghong Li, Sensitive Electrochemical Aptamer Biosensor for Dynamic Cell Surface N-Glycan Evaluation Featuring Multivalent Recognition and Signal Amplification on a Dendrimer-Graphene Electrode Interface. Analytical Chemistry, 2014 86,(9),4278-4286. Yinhui Yi,Gangbing Zhu,Chang Liu,Yan Huang,Youyu Zhang*,Haitao Li,Jiangna Zhao,Shouzhuo Yao, A Label-Free Silicon Quantum Dots-Based Photoluminescence Sensor for Ultrasensitive Detection of Pesticides. Analytical Chemistry, 2013 85,(23),11464-11470. Youyu Zhang,Zhiwen Tang,Jun Wang,Hong Wu,Aihui Maham,Yuehe Lin*, Hairpin DNA Switch for Ultrasensitive Spectrophotometric Detection of DNA Hybridization Based on Gold Nanoparticles and Enzyme Signal Amplification. Analytical Chemistry, 2010 82,(15),6440-6446. Qiujun Lu,Jianhui Deng,Yuxin Hou,Haiyan Wang,Haitao Li,Youyu Zhang*, One-step electrochemical synthesis of ultrathin graphitic carbon nitride nanosheets and their application to the detection of uric acid. Chemical Communications, 2015 51,(61),12251-12253. Qiujun Lu,Jianhui Deng,Yuxin Hou,Haiyan Wang,Haitao Li,Youyu Zhang*,Shouzhuo Yao, Hydroxyl-rich C-dots synthesized by a one-pot method and their application in the preparation of noble metal nanoparticles. Chemical Communications, 2015 51,(33),7164-7167. Qiong Chen,Meiling Liu,Jiangna Zhao,Xue Peng,Xiaojiao Chen,Naxiu Mi,Bangda Yin,Haitao Li,Youyu Zhang*,Shouzhuo Yao, Water-dispersible silicon dots as a peroxidase mimetic for the highly-sensitive colorimetric detection of glucose. Chemical Communications, 2014 50,(51),6771-6774. Mingjie Wei,Peng Yin,Youming Shen,Lingli Zhang,Jianhui Deng,Shanyan Xue,Haitao Li,Bin Guo,Youyu Zhang*,Shouzhuo Yao, A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells. Chemical Communications, 2013 49,(41),4640-4642. Yinhui Yi,Jianhui Deng,Youyu Zhang*,Haitao Li,Shouzhuo Yao, Label-free Si quantum dots as photoluminescence probes for glucose detection. Chemical Communications, 2013 49,(6),612-614. Jianhui Deng,Qiujun Lu,Naxiu Mi,Haitao Li,Meiling Liu,Mancai Xu,Liang Tan,Qingji Xie,Youyu Zhang*,Shouzhuo Yao, Electrochemical Synthesis of Carbon Nanodots Directly from Alcohols. Chemistry-a European Journal, 2014 20,(17),4993-4999. Youyu Zhang,Zhiwen Tang,Jun Wang,Hong Wu,Chiann-Tso Lin,Yuehe Lin*, Apoferritin nanoparticle: a novel and biocompatible carrier for enzyme immobilization with enhanced activity and stability. Journal Of Materials Chemistry, 2011 21,(43),17468-17475. Mingxia Li,Haiyan Wang,Xiaoxia Wang,Qiujun Lu,Haitao Li,Youyu Zhang*,Shouzhuo Yao, Ti3C2/Cu2O heterostructure based signal-off photoelectrochemical sensor for high sensitivity detection of glucose. Biosensors & Bioelectronics, 2019 142. Qiujun Lu,Haiyan Wang,Yalan Liu,Yuxin Hou,Haitao Li,Youyu Zhang*, Graphitic carbon nitride nanodots: As reductant for the synthesis of silver nanoparticles and its biothiols biosensing application. Biosensors & Bioelectronics, 2017 89411-416. Aijin Fang,Hongyu Chen,Haitao Li,Meiling Liu*,Youyu Zhang*,Shouzhuo Yao, Glutathione regulation-based dual-functional upconversion sensing-platform for acetylcholinesterase activity and cadmium ions. Biosensors & Bioelectronics, 2017 87545-551. Aijin Fang,Qiongqiong Wu,Qiujun Lu,Hongyu Chen,Haitao Li,Meiling Liu*,Youyu Zhang*,Shouzhuo Yao, Upconversion ratiometric fluorescence and colorimetric dual-readout assay for uric acid. Biosensors & Bioelectronics, 2016 86664-670. Qian Long,Aijin Fang,Yanqing Wen,Haitao Li,Youyu Zhang*,Shouzhuo Yao, Rapid and highly-sensitive uric acid sensing based on enzymatic catalysis-induced upconversion inner filter effect. Biosensors & Bioelectronics, 2016 86109-114. Qiongqiong Wu,Aijin Fang,Haitao Li,Youyu Zhang*,Shouzhuo Yao, Enzymatic-induced upconversion photoinduced electron transfer for sensing tyrosine in human serum. Biosensors & Bioelectronics, 2016 77957-962. Qian Long,Haitao Li,Youyu Zhang*,Shouzhuo Yao, Upconversion nanoparticle-based fluorescence resonance energy transfer assay for organophosphorus pesticides. Biosensors & Bioelectronics, 2015 68168-174. Meiling Liu,Jianhui Deng,Qiong Chen,Yan Huang,Linping Wang,Yan Zhao,Youyu Zhang*,Haitao Li,Shouzhuo Yao*, Sensitive detection of rutin with novel ferrocene benzyne derivative modified electrodes. Biosensors & Bioelectronics, 2013 41275-281. Jie Zhao,Youyu Zhang*,Haitao Li,Yanqing Wen,Xiaoyu Fan,Fanbo Lin,Liang Tan,Shouzhuo Yao, Ultrasensitive electrochemical aptasensor for thrombin based on the amplification of aptamer-AuNPs-HRP conjugates. Biosensors & Bioelectronics, 2011 26,(5),2297-2303. Min Ye,Youyu Zhang*,Haitao Li,Yuqin Zhang,Ping Tan,Hao Tang,Shouzhuo Yao, A novel method for the detection of point mutation in DNA using single-base-coded CdS nanoprobes. Biosensors & Bioelectronics, 2009 24,(8),2339-2345. Mingxia Li,Qiujun Lu,Meiling Liu,Peng Yin,Cuiyan Wu,Haitao Li,Youyu Zhang*,Shouzhuo Yao, Photoinduced Charge Separation via the Double-Electron Transfer Mechanism in Nitrogen Vacancies g-C3N5/BiOBr for the Photoelectrochemical Nitrogen Reduction. Acs Applied Materials & Interfaces, 2020 12,(34),38266-38274. Dan Liu,Gong Zhang,Qinghua Ji,Youyu Zhang*,Jinghong Li*, Synergistic Electrocatalytic Nitrogen Reduction Enabled by Confinement of Nanosized Au Particles onto a Two-Dimensional Ti3C2 Substrate. Acs Applied Materials & Interfaces, 2019 11,(29),25758-25765. Na Huang,Si Zhang,Liuqing Yang,Meiling Liu*,Haitao Li,Youyu Zhang*,Shouzhuo Yao, Multifunctional Electrochemical Platforms Based on the Michael Addition/Schiff Base Reaction of Polydopamine Modified Reduced Graphene Oxide: Construction and Application. Acs Applied Materials & Interfaces, 2015 7,(32),17935-17946. Qiongqiong Wu,Hongyu Chen,Aijin Fang,Xinyang Wu,Meiling Liu*,Haitao Li,Youyu Zhang*,Shouzhuo Yao, Universal Multifunctional Nanoplatform Based on Target-Induced in Situ Promoting Au Seeds Growth to Quench Fluorescence of Upconversion Nanoparticles. Acs Sensors, 2017 2,(12),1805-1813. Qujun Lu,Hu Dong,Jiali Hu,Linna Huang,Youyu Zhang*,Mingxia Li,Meiling Liu,Yaqian Li,Cuiyan Wu*,Haitao Li, Insight into the Effect of Ligands on the Optical Properties of Germanium Quantum Dots and Their Applications in Persistent Cell Imaging. Langmuir, 2020 36,(41),12375-12382. Jiali Hu,Qiujun Lu,Cuiyan Wu,Meiling Liu,Haitao Li,Youyu Zhang*,Shouzhuo Yao, Synthesis of Fluorescent and Water-Dispersed Germanium Nanoparticles and Their Cellular Imaging Applications. Langmuir, 2018 34,(30),8932-8938. Haiyan Wang,Mingxia Li,Qiujun Lu,Yuemei Cen,Youyu Zhang*,Shouzhuo Yao*, A Mesoporous Rod-like g-C3N5 Synthesized by Salt-Guided Strategy: As a Superior Photocatalyst for Degradation of Organic Pollutant. Acs Sustainable Chemistry & Engineering, 2019 7,(1),625-631. Haiyan Wang,Mingxia Li,Huan Li,Qiujun Lu,Youyu Zhang*,Shouzhuo Yao, Porous graphitic carbon nitride with controllable nitrogen vacancies: As promising catalyst for enhanced degradation of pollutant under visible light. Materials & Design, 2019 162210-218.

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