刘剑波 - 湖南大学 - 化学化工学院

个人简介

刘剑波，男，博士，湖南大学化学化工学院教授；化学生物传感与计量学国家重点实验室、生物纳米与分子工程湖南省重点实验室成员。2011年获得湖南大学博士学位。2017-2019年在英国布里斯托大学开展博士后研究。获得中国十大新锐科技人物（2021 年），湖南省科技创新领军人才（2022年），湖南省杰出青年基金（2021年），湖南大学岳麓学者称号（2017年），湖南大学中国共产党成立100周年优秀党员（2021年）等荣誉。在教学方面，承担国家精品课程《分析化学》、《环境化学》、《数据分析与科研绘图》等本科生与研究生课程。在科研方面，主要开展化学生物学与分析化学方面的研究，主持科研项目十余项，包括国家自然科学基金4项，湖南省自然科学基金3项；参与国家自然科学基金重大项目等。围绕人工细胞的化学合成以及化学生物分析与生物医学应用开展研究。发表学术论文100余篇，包括 Nat. Chem., Nat. Comm., J. Am. Chem. Soc., Angew. Chem. 等通讯作者论文 50 余篇。授权发明专利 9 项。相关工作在湖南日报、红网、搜狐、网易，“学习强国”客户端，以及ScienceDaily，EurekAlert等国外媒体进行新闻报道。教育背景 2006–2011，湖南大学，分析化学，博士 (导师：王柯敏教授) 2004–2006，湖南大学，生物医学工程，硕士 (导师：王柯敏教授) 2000–2004，湖南大学，化学（应用化学试点班），学士工作履历 2022--至今，湖南大学，化学化工学院，教授 2014-至今，湖南大学，化学化工学院，副教授 2017-2019，英国布里斯托大学，化学学院，博士后（合作导师： Stephen Mann FRS） 2011-2014，湖南大学，化学化工学院，助理研究员

研究领域

化学生物学：人工细胞的化学构建及其生物医学应用研究分析化学：纳米与分子尺度水平上的化学生物分析

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Hui Chen, Wanyu Xu, Hui Shi, Yan Qiao, Xiaoxiao He, Jing Zheng, Shaohong Zhou, Xiaohai Yang, Kemin Wang, Jianbo Liu*. DNA-based artificial receptors as transmembrane signal transduction systems for protocellular communication. Angewandte Chemie International Edition, 2023, 62, e202301559. Yanwen Zhang#, Zefeng Wang#, Mei Li, Can Xu, Ning Gao, Zhuping Yin, Kemin Wang, Stephen Mann,* Jianbo Liu.* Osmotic-induced reconfiguration and activation in membranized coacervate-based protocells. Journal of the American Chemical Society. Accepted, DOI: 10.1021/jacs.3c02540, ASAP. Zefeng Wang, Min Zhang, Yan Zhou, Yanwen Zhang, Kemin Wang, Jianbo Liu*. Coacervate microdroplets as synthetic protocells for cell mimicking and signaling communications. Small Methods, 2023, 7, 2300042. Yanwen Zhang, Shixin Wang, Yuling Yan, Xiaoxiao He, Zefeng Wang, Shaohong Zhou, Xiaohai Yang, Kemin Wang, Jianbo Liu*. Phase-separated bienzyme compartmentalization as artificial intracellular membraneless organelles for cell repair. Science China Chemistry, 2023, 66, 845-852. https://doi.org/10.1007/s11426-022-1491-0 Yang Li, Songyang Liu, Wanyu Xu, Kemin Wang, Fengjiao He,* Jianbo Liu.* Formation of giant plasma membrane vesicles for biological and medical applications: a review. Sensors & Diagnostics, 2023, Accepted Manuscript. DOI: 10.1039/D3SD00060E. Songyang Liu, Yanwen Zhang, Xiaoxiao He, Mei Li, Jin Huang, Xiaohai Yang, Kemin Wang, Stephen Mann*, Jianbo Liu* Signal processing and generation of bioactive nitric oxide in a model prototissue. Nature Communications, 2022, 13, 5254. https://www.nature.com/articles/s41467-022-32941-6 Yufeng Chen, Min Yuan, Yanwen Zhang, Shaohong Zhou, Kemin Wang, Zhenjun Wu*, Jianbo Liu.* Enzyme-active liquid coacervate microdroplets as artificial membraneless organelles for intracellular ROS scavenging. Biomaterial Science 2022,10, 4588-4595. Shaohong Zhou, Xueer Cai, Yanwen Zhang, Qiaoshu Chen, Xiaohai Yang, Kemin Wang, Lixin Jian,* Jianbo Liu* DNA nanotubes in coacervate microdroplets as biomimetic cytoskeletons modulate the liquid fluidic properties of protocells. Journal of Materials Chemistry B, 2022, 10, 8322-8329. Xue'er Cai, Meiling Jian, Shaohong Zhou, Zefeng Wang, Kemin Wang, Jianbo Liu.* Chemical construction of artificial cells and their biomedical applications. Progress in Chemistry, 2022, 34, 2462-2475. DOI: 10.7536/PC220308. Hui Chen, Li Zhou (co-author), Chunying Li, Xiaoxiao He, Jin Huang, Xiaohai Yang, Hui Shi,* Kemin Wang, Jianbo Liu.* Controlled dimerization of artificial membrane receptors for transmembrane signal transduction. Chemical Science, 2021, 12, 8224-8230. https://doi.org/10.1039/D1SC00718A Yanwen Zhang, Yufeng Chen, Xiaohai Yang, Xiaoxiao He, Mei Li, Songyang Liu, Kemin Wang, Jianbo Liu*, Stephen Mann.* Giant coacervate vesicles as an integrated approach to cytomimetic modeling. Journal of the American Chemical Society, 2021, 143, 2866−2874. https://doi.org/10.1021/jacs.0c12494 Qiaoshu Chen, Meiling Jian, Hui Chen, Bing Zhou, Hui Shi, Xiaohai Yang, Kemin Wang, Jianbo Liu.* Design of lipophilic split aptamers as artificial carriers for transmembrane transport of adenosine triphosphate. CCS Chemistry, 2021, 3, 144-153. https://doi.org/10.31635/ccschem.020.202000591 Yanwen Zhang, Yu Yao, Songyang Liu, Yufeng Chen, Shaohong Zhou, Kemin Wang, Xiaohai Yang,* Jianbo Liu.* Coacervate microdroplet protocells-mediated gene transfection for nitric oxide production and induction of cell apoptosis. Journal of Materials Chemistry B, 2021, 9, 9784-9793 Qiaoshu Chen, Yanwen Zhang, Hui Chen, Jianbo Liu,* Juewen Liu.* Enhancing the sensitivity of DNA and aptamer probes in the Dextran/PEG aqueous two-phase system. Analytical Chemistry, 2021, 93, 8577–8584. https://doi.org/10.1021/acs.analchem.1c01419 Yu Yao#, Yanwen Zhang (co-author)#, Li Li, Yan Huang, Xiaohai Yang, Zhihong Peng,* Kemin Wang, Jianbo Liu.* Photothermally activated coacervate model protocells as signal transducers endow mammalian cells with light sensitivity. Advanced Biology, 2021, 5, 2100695. https://doi.org/10.1002/adbi.202100695. Chunying Li, Hui Chen, Xiaohai Yang,* Kemin Wang, Jianbo Liu.* An ion transport switch based on light-responsive conformation-dependent G-quadruplex transmembrane channels. Chemical Communications, 2021, 57, 8214-8217. https://doi.org/10.1039/D1CC03273A Yufeng Chen, Yanwen Zhang, Mei Li, Songyang Liu, Xiaohai Yang, Kemin Wang, Stephen Mann,* Jianbo Liu.* Self-immobilization of coacervate droplets by enzyme-mediated hydrogelation. Chemical Communications, 2021,57, 5438-5441. https://doi.org/10.1039/D1CC01483H Songyang Liu, Yanwen Zhang, Mei Li, Li Xiong, Zijian Zhang, Xiaohai Yang, Xiaoxiao He, Kemin Wang, Jianbo Liu,* Stephen Mann.* Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells. Nature Chemistry, 2020, 12, 1165-1173. https://www.nature.com/articles/s41557-020-00585-y Jianbo Liu,* Liangfei Tian, Yan Qiao, Shaohong Zhou, Avinash J. Patil, Kemin Wang, Mei Li,* Stephen Mann.* Hydrogel-immobilized coacervate droplets as modular microreactor assemblies. Angewandte Chemie International Edition, 2020, 59, 6853 – 6859. (Hot paper, Cover Article) Yanwen Zhang, Songyang Liu, Yu Yao, Yufeng Chen, Shaohong Zhou, Xiaohai Yang, Kemin Wang,* Jianbo Liu.* Invasion and defense interactions between enzyme-active liquid coacervate protocells and living cells. Small, 2020, 16, 20020733 (Cover Article). Yufeng Chen, Min Yuan, Yanwen Zhang, Songyang Liu, Xiaohai Yang, Kemin Wang,* Jianbo Liu.* Construction of coacervate-in-coacervate multicompartment protocells for spatial organization of enzymatic reactions. Chemical Science, 2020, 11, 8617–8625. Chunying Li, Hui Chen, Qiaoshu Chen, Hui Shi,* Xiaohai Yang, Kemin Wang, Jianbo Liu.* Lipophilic G-quadruplex isomers as biomimetic ion channels for conformation- dependent selective transmembrane transport. Analytical Chemistry, 2020, 92, 10169–10176. Qiaoshu Chen, Yibo Liu, Jianbo Liu,* Juewen Liu.* Liposome boosted peroxidase mimicking nanozymes breaking the pH limit. Chemistry - A European Journal, 2020, 26, 16659-16665 (Hot paper). Yingben Wu,* Yan Liu (co-author), Huizhi Liu, Biao Liu, Wei Chen, Lijuan Xu, Jianbo Liu.* Ion-mediated self-assembly of Cys-capped quantum dots for fluorescence detection of As(III) in water. Analytical Methods, 2020, 12, 4229–4234. Yan Huang, Haifeng Li, Xiaoxiao He, Xiaohai Yang, Li Li, Songyang Liu, Zhen Zou, Kemin Wang,* Jianbo Liu.* Near-infrared photothermal release of hydrogen sulfide from nanocomposite hydrogels for anti-inflammation applications. Chinese Chemical Letters, 2020, 31, 787-791. Miaomiao Zhuang, Yanwen Zhang, Shaohong Zhou, Yun Zhang, Kemin Wang, Jinfang Nie,* Jianbo Liu.* Uricase-containing coacervate microdroplets as enzyme active membrane-free protocells for detoxification of uric acid in serum. Chemical Communications, 2019, 55, 13880-13883. Chunying Li, Hui Chen, Li Zhou, Hui Shi, Xiaoxiao He, Xiaohai Yang,* Kemin Wang, Jianbo Liu.* Single-stranded DNA designed lipophilic G-quadruplexes as transmembrane channels for switchable potassium transport. Chemical Communications, 2019, 55, 12004-12007. (Cover Page) Haifeng Li, Yu Yao, Hui Shi, Yanli Lei, Yan Huang, Kemin Wang, Xiaoxiao He,* Jianbo Liu.* Near-infrared light-responsive nanocomposite for photothermal release of H2S and suppression of cell viability. Journal of Materials Chemistry B, 2019, 7, 5992-5997. Qiaoshu Chen, Shaohong Zhou, Chunying Li, Qiuping Guo, Xiaohai Yang, Jin Huang, Jianbo Liu,* Kemin Wang.* DNA supersandwich assemblies as artificial receptors to mediate intracellular delivery of catalase for efficient ROS scavenging. Chemical Communications, 2019, 55, 4242-4245. Li Li, Gui Li, Xiaoxiao He, Xiaohai Yang, Songyang Liu, Jinlu Tang, Qiaoshu Chen, Jianbo Liu,* Kemin Wang.* Protein- driven disassembly of surfactant- polyelectrolyte nanomicelles: Modulation of quantum dot/fluorochrome FRET for pattern sensing. Sensors and Actuators B: Chemical, 2018, 272, 393-399. Li Zhou, Yu Liu, Hui Shi, Xiaohai Yang, Jin Huang, Songyang Liu, Qiaoshu Chen, Jianbo Liu,* Kemin Wang.* Flexible assembly of an enzyme cascade on a DNA triangle prism nanostructure for the controlled biomimetic generation of nitric oxide. ChemBioChem. 2018, 19, 2099-2106. Wei Liu, Jue Zhang, Zhihong Peng, Xiaohai Yang, Li Li, Qiaoshu Chen, Jianbo Liu,* Kemin Wang.* Controlled formation of Ag2S/Ag Janus nanoparticles using alkylamine as reductant surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2018, 544, 111-117.