个人简介
PROFESSIONALEXPERIENCE
ChangzhouUniversity(常州大学),since2007.05
EDUCATIONALBACKGROUND
KyungHeeUniversity(庆熙大学,韩国首尔),Ph.D.(2007)
ShenyangPharmaceuticalUniversity(沈阳药科大学),M.S.(2003)
ShenyangPharmaceuticalUniversity(沈阳药科大学),B.S(2001)
RESEARCHINTERESTS
Pharmacology
MedicinalChemistry
AWARDSANDRECOGNITIONS
ExcellentadvisorofundergraduatethesisforClassof2012,ChangzhouUniversity.
(常州大学2012届本科毕业论文优秀指导教师)
Outstandingyoungbackboneteacherof“QingLanProject”ofJiangsuProvince(2012)
(江苏省“青蓝工程”优秀青年骨干教师)(2012)
ExcellentguidanceteamofundergraduatethesisforClassof2012,JiangsuProvince.
江苏省2012届优秀毕业论文指导团队,江苏省教育厅,一等奖
Excellentteacher,ChangzhouUniversity.(2012)
常州大学优秀教师(2012)
FUNDINGS
ChangzhouBasicResearchProgram(ApplicationProgram),(2013-2015,PI)
常州市应用基础研究项目(2013-2015),主持人
国家六类新药临床前研究开发(企业合作项目)(2013年),主持人
NationalScienceFoundationofChinaproject(grantNo.21202012),(2012-2015,PI)
国家自然科学基金青年基金(2012-2015),主持人
2010IndustryforAttractingPh.D.ScientistsProgramofJiangsuProvince,(2010,PI)
江苏省企业博士集聚计划资助基金(2010),主持人
ChangzhouUniversityTalentIntroductionFund,(2007,PI),
常州大学人才引进基金(2007),主持人
PATENT
1.“高纯4,6-二甲氧基-2-((苯氧基羰基)氨基)-嘧啶制备方法”,胡昆,高学明,宋国强,蒋军,任杰,专利号:ZL200810243711.6.
2.“萝卜硫素的合成方法”,陈新,孙小强,李正义,任杰,胡昆,专利号:ZL201110162525.1.
3.“萝卜硫素衍生物及其制备方法和用途”,胡昆,祁燕杰,任杰,陈新,赵娟,专利申请号:201210296425.2.已授权。
4.“新型抗菌剂酰基苯氧乙酸、酰基肉桂酸及其制备方法”,陈新,张成芳,董爱玲,周珊珊,赵丽,任杰,胡昆,专利申请号:201210222626.8.
5.“4-胺基噁二唑表鬼臼毒素衍生物及其制备方法和用途”,胡昆,任杰,吴琳,辛文群,专利申请号:201110362604.7.专利公开号:CN102229563.
6.“4-氨基喹啉衍生物及其制备方法和用途”,胡昆,任杰,刘显华,程虹,专利申请号:201110104802.3.专利公开号:CN102229563.
7.“酰基苯氧乙酸类化合物及其制备方法”,陈新,张成芳,董爱玲,周珊珊,赵丽,任杰,胡昆,专利申请号:201310467090.0)。
8.“肉桂羟肟酸类化合物及其制备方法”,陈新,张成芳,董爱玲,周珊珊,赵丽,任杰,胡昆,专利申请号:201310466747.1。
近期论文
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1.“DMPPQA,anovelangiogenesisinhibitor,inducesapoptosisinhumancoloncancerHCT-116cellsandHUVECs”,JieRen*,HefeiJiang,JuanZhao,WenqunXin,YuanyuanXu,XinChenandKunHu*,CellBiologyInternational,2014,doi:10.1002/cbin.10209.
2.“Biotransformationof20(S)-protopanaxadiolbyAspergillusnigerAS3.1858”,Guang-tongChen,XueYang,JianlinLi,HongjuanGe,YanSong,JieRen*,Fitoterapia,2013,91,256-260.
3.“Synthesisandbiologicalevaluationofnovelsulforaphanederivativesaspotentialantitumoragents”,KunHu,Yan-jieQi,JuanZhao,He-feiJiang,XinChen*,JieRen*,EuropeanJournalofMedicinalChemistry,2013,64,529-539.
4.“SynthesisandantitumoractivityofN-sulfonyl-3,7-dioxo-5-cholan-24-amides,ursodeoxycholicacidanalogues”,JieRen,YongchaoWang,JunliangWang,JunLin,KunWei,RongHuang,Steroids,2013,78,53-58.
5.“Synthesisandbiologicalevaluationofanticanceractivityfornovel4β-aminooxadiazolederivativesofpodophyllotoxin”,JieRen,LinWu,Wen-QunXin,XinChen,KunHu*,Bioorganic&MedicinalChemistryLetters,2012,22,4778-4782.
6.“Synthesisandantitumoractivityofformononetinnitrogenmustardderivatives”,JieRen,Hua-JinXu,HongCheng,Wen-QunXin,XinChen,KunHu*,EuropeanJournalofMedicinalChemistry,2012,54,175-187.
7.“Apoptosisinductionof7-piperazinethylchrysininHCT-116humancoloncancercells”,JieRen,HongCheng,Wen-QunXin,XinChen,KunHu*,OncologyReport,2012,28,1719-1726.
8.“Synthesisandantitumoractivityofnovel4-aminoquinolinederivatives”,JieRen,JuanZhao,Yong-ShengZhou,Xian-HuaLiu,XinChen,KunHu*,MedicinalChemistryResearch,2012,DOI10.1007/s00044-012-0283-8.2013,22,2855-261.
9.“Newmethodforsynthesisofsulforaphaneandtherelatedisothiocyanates”,XinChen,ZhengyiLi,XiaoqiangSun,HongzhaoMa,XiaoxinChen,JieRen,KunHu,Synthesis,2011,3991-3996.
10.“AntitumoractivityofdichloromethaneextractsfromSalviaplebeiaandinductionofapoptosisonK562”,RenJie,PanSha-sha,LuXu-zhang,ZhouMin,HuKun*,ChineseHerbalMedicines,2010,3(1):36-40.
11.“Synthesisandantitumoractivityofliquiritigeninthiosemicarbazonederivatives”,KunHu,Ze-HuaYang,Sha-ShaPan,Hua-JinXu,JieRen*,EuropeanJournalofMedicinalChemistry,2010,45:3453-3458.
12.“Synthesisandcytotoxicityofnovelchrysinderivatives”,KunHu,WeiWang,HongCheng,Sha-ShaPan,JieRen*,MedicinalChemistryResearch,2010,20(7):838-846.
13.“Anti-inflammatoryeffectofα-linolenicacidanditsmodeofactionthroughtheinhibitionofnitricoxideproductionandiNOSgeneexpressionviaNF-κBandMAPkinasepathways”,RenJie,ChungSung-Hyun*,JournalofAgriculturalandFoodChemistry,2007,(13):5073-5080.
14.“InvivoandInvitroanti-inflammatoryeffectsofα-linolenicacidisolatedfromActinidiapolygamafruits”,RenJie,HanEun-Jung,ChungSung-Huyn*,ArchivesofPharmacalResearch,2007,30:708-714.
15.“PolyphenolCompoundsfromVitisthunbergiiSiebetZucc”,De-QiangDou,JieRen,MaggieCooper,Yue-HuaHe,Yu-PingPei,YoshiakiTakaya,MasatakeNiwa,Ying-JieChen,Xin-ShengYaoandRen-PingZhou,JournalofChinesePharmaceuticalSciences,2003,12(2),57-59.
16.“ANewCompoundfromForsythiaSuspensa(Thunb.)VahlwithAntiviralEffectonRSV”.Guo-GangZhang,Shao-JiangSong,JieRenandSui-XuXu*,JournalofHerbalPharmacotherapyTM,2002,2(3),35-40.
17.“Ocotillone-typeGinsenosidefromLeavesofPanaxginseng”.De-QiangDou,YingChen,JieRen,Yu-PingPeiandYing-JieChen*,JournalofChinesePharmaceuticalSciences,2002,11(4),119-121.
18.“鬼臼毒素衍生物OAMDP诱导Hela细胞凋亡”,任杰,辛文群,陈新,胡昆*,中国药科大学学报,2013,44(3):267-271.
19.“刺芒柄花素氮芥衍生物的合成及抗肿瘤活性”,胡昆,徐华金,辛文群,陈新,任杰*,中国药科大学学报,2012,43(2):113-119.
20.“4β-(1,3,4-噁二唑-2-氨基)鬼臼毒素衍生物的合成及其抗癌活性”,胡昆,吴琳,辛文群,陈新,任杰*,沈阳药科大学学报,2012,29(6):427-433.
21.“木犀草素Mannich碱衍生物的合成及其抗癌活性研究”,任杰,潘莎莎,程虹,胡昆*,中国新药杂志,2011,20(8):743-747.
22.“甘草素缩胺硫脲类衍生物的合成及抗癌活性”,任杰,潘莎莎,胡昆*,沈阳药科大学学报,2011,28(3):192-197.
23.“白杨素衍生物的合成及其抗肿瘤活性”,任杰,程虹,王炜,胡昆*,中国药科大学学报,2011,42(3):206-212.
24.“金色草素的全合成”,胡昆,刘显华,任杰*,合成化学,2011,19(1):115-117.
25.“(±)-二氢槲皮素的全合成”,胡昆,王振山,刘显华,任杰*,化学试剂,2011,33(1):82-84.
26.“三粒小麦黄酮的全合成”,胡昆,王炜,任杰*,天然产物研究与开发,2010,22(6):1028-1030.
27.“天然产物Thienamycin的全合成研究进展”,胡昆,王振山,任杰*,化工技术与开发,2010,39(3),19-26.
28.“白杨素Mannich碱衍生物的合成及其抗癌活性”,胡昆,王炜,任杰*,沈阳药科大学学报,2010,27(6):448-452.
29.“2-氨基-5,7-二甲氧基-1,2,4-三嗪并【1,5-α】嘧啶的合成及工艺优化”,胡昆,宁红锋,任杰*,化学世界,2010,51(7):418-420.
30.“甘草素的合成及抗癌活性”,胡昆,杨泽华,刘显华,任杰*,合成化学,2010,18(4):513-516.
31.“α-亚麻酸的体外抗炎作用机制研究”,任杰,杨泽华,郑圣顯,胡昆*,云南大学学报,2009,31:419-426.
32.“匹多莫德的合成”,胡昆,王振山,任杰*,中国医药工业杂志,2009,40(12):883-884.
33.“天然产物Quadrone的全合成进展”,胡昆,杨泽华,任杰*,江苏工业学院学报,2009,21(3):73-78.
34.“橙皮素的全合成”,胡昆,杨泽华,任杰*,云南大学学报,2009,31:427-42.
35.“高效液相色谱法测定人参提取物及其胶囊中人参皂甙Rb-1的含量”,任杰,窦德强,赵春杰,裴玉萍,陈英杰*,人参研究,2003,3:5-9.
36.“商品人参根的化学成分研究”,窦德强,任杰,陈颖,裴玉萍,陈英杰*,中国中药杂志,2003,6.