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个人简介

FUNDINGS: 2016国家自然科学基金面上项目(项目批准号:21672027) 2013国家自然科学基金面上项目(项目批准号:21272077) PROFESSIONALEXPERIENCE: 2012-presentProfessor SchoolofPharmaceuticalandLifeSciences,ChangzhouUniversity,China. 2010-2012AssociateProfessor EastChinaNormalUniversity,Shanghai.(华东师范大学) 2009-2010SeniorResearchScientist PharmaResourcesShanghaiCO.LTD.(上海鸿博智源医药研究有限公司) 2007-2009PostdoctoralResearchAssociate ChemistryDepartment,UniversityofWisconsin-Madison,USA.(威斯康星大学-麦迪逊分校) 2003-2007TeachingAssistantandResearchAssistant ChemistryDepartment,UniversityofIllinoisatChicago,USA.(伊利诺依大学-芝加哥分校) 2000-2003AssistantResearcher DaiweiMa’sResearchGroup,ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciences(中国科学院上海有机化学研究所) EDUCATIONALBACKGROUND: 2007Ph.DinOrganicChemistry,ChemistryDepartment,UniversityofIllinoisatChicago,USA.(伊利诺依大学-芝加哥分校) 2000MasterinOrganicChemistry,EastChinaUniversityofScienceandTechnology(Shanghai,P.R.China)(华东理工大学) 1998BachelorinChemistry,LanzhouUniversity(兰州大学)

研究领域

OrganicmethodologyresearchbyOrganometallicChemistryandSugarChemistry. (有机方法学研究,重点运用金属有机化学方法和糖化学方法) Drugresearchanddevelopmentfortreatingcancers. (新型抗癌药物的研究)

近期论文

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1.Hua-DongXu*,HaoZhou,Ying-PengPan,Xin-TaoRen,HaoWu,MeiHan,Run-ZeHan,Mei-HuaShen*.StereoselectiveSynthesisofPolycyclesContaininganAziridineGroup:Intramolecularaza-Diels-AlderReactionsofUnactivated2H-AzirineswithUnactivatedDienes.Angew.Chem.,Int.Ed.2016,55(07),2540-2544.(Publishedonline:January12,2016) 2.HaoZhou,Mei-HuaShen*,Hua-DongXu*.EvolutionoftheAza-Diels-Alderreactionof2H-azirines.SynlettReview2016,27,2171-2177 3.Hua-DongXu*,HaoWu,ChunJiang,PengChen,Mei-HuaShen*.Chemo-,regio-,andstereoselectivehydroborationofconjugatedenynealcohol/amine:facilesynthesisofZ,Z-/Z,E-1,3-dien-1/2-ylboronicesterbearinghydroxyl/aminogroup.TetrahedronLett.2016,57(26),2915-2918. 4.Xiao-LongLu,Ya-TingLiu,Qiang-XiaWang,Mei-HuaShen*,Hua-DongXu*.Straightforwardregioselectiveconstructionof3,4-dihydro-2H-1,4-thiazinebyrhodiumcatalysed[3+3]cycloadditionofthiiranewith1-sulfonyl-1,2,3-triazole:apronouncedacidadditiveeffect.Org.Chem.Front.,2016,3(6),725-729. 5.Mei-HuaShen*,MeiHan,Hua-DongXu*.One-PotConversionofN‑Allyl-α-cyanoEsterstoα‑Allyl-α-cyanoLactamsthroughaHydrolysis/KeteneFormation/Cyclization/ClaisenRearrangementSequence.Org.Lett.2016,18(5),889-891. 6.Hua-DongXu*,HaoZhou,Ying-PengPan,Xin-TaoRen,HaoWu,MeiHan,Run-ZeHan,Mei-HuaShen*.StereoselectiveSynthesisofPolycyclesContaininganAziridineGroup:Intramolecularaza-Diels-AlderReactionsofUnactivated2H-AzirineswithUnactivatedDienes.Angew.Chem.,Int.Ed.2016,55(07),2540-2544.(Publishedonline:January12,2016) 7.Mei-HuaShen*,KeXu,Chu-HanSun,Hua-DongXu.Facilesynthesisofaza-spirocyclopropanyloxindolesbythereactionof3-(2-bromoethyl)-indolewith2,3-dimethylimidazole-1-sulfonylazidetriflate.Org.Biomol.Chem.,2016,14(04),1272-1276. 8.Mei-HuaShen*,KeXu,Chu-HanSun,Hua-DongXu*.StereoselectiveConstructionofBridgedtrans-aza-Bicyclo[7/6,3/2,1]alkenylIminesthroughRingExpansionaza-CopeRearrangement.Org.Lett.2015,17(22),5598-5601. 9.Mei-HuaShen,*Xiao-LongLu,Hua-DongXu*.Copper(II)acetatecatalysedring-openingcrosscouplingofcyclopropanolswithsulfonylazides.RSCAdv.2015,5(120),98757-98761. 10.Hua-DongXu*,Ying-PengPan,Xin-TaoRen,PingZhang,Mei-HuaShen*.Aone-potconstructionofacridonesbyrhodiumcatalyzedreactionofN-phenyl-2-(1-sulfonyl-1H-1,2,3-triazol-4-yl)aniline.TetrahedronLett.2015,56(48),6734-6737. 11.Mei-HuaShen*,KeXu,Chu-HanSun,Hua-DongXu*.TheReactionof2,3-Dimethylimidazole-1-sulfonylAzideTriflatewith3-SubstitutedIndoles:ReactivityandScope.Org.Lett.2015,17(15),3654-3657. 12.Xian-HuaPan*,PanJiang,Zhi-HongJia,KeXu,JingCao,ChangChen,Mei-HuaShen,Hua-DongXu*.Expedientcatalyticconstructionofazabicyclo[4.1.0]/[5.1.0]carbaldehydesviaintramolecularcyclopropanation.Tetrahedron2015,71(32),5124-5129. 13.Mei-HuaShen*,Ying-PengPan,Zhi-HongJia,Xin-TaoRen,PingZhang,Hua-DongXu*.Anefficientapproachto1,2,3-trisubstitutedindoleviarhodiumcatalyzedcarbeneCsp3–Hbondinsertion.Org.Biomol.Chem.,2015,13(17),4851-4854. 14.Hua-DongXu*,Zhi-HongJia,KeXu,HaoZhou,Mei-HuaShen*.One-PotProtocoltoFunctionalizedBenzopyrrolizidineCatalyzedSuccessivelybyRh2(OAc)4andCu(OTf)2:ATransitionMetal–LewisAcidCatalysisRelay.Org.Lett.2015,17(01),66-69. 15.Hua-DongXu*,KeXu,HaoZhou,Zhi-HongJia,HaoWu,Xiao-LongLu,Mei-HuaShen*.Ring-Strain-DrivenCatalyticCarbeneFormation-Cyclopropanation-Aza-CopeRearrangementCascade:AFacileEntrytoFusedDihydroazepinesfrom1,3-Dienyltriazoles.Synthesis2015,47(05),641-646. 16.Hua-DongXu*,KeXu,QingZheng,Wei-JieHe,Mei-HuaShen*,Wen-HaoHu.Step-economyetherificationofacylatedalcohols.TetrahedronLett.2014,55(50),6836-6838. 17.Hua-DongXu*,KeXu,Zhi-HongJia,HaoZhou,PanJiang,Xiao-LongLu,Ying-PengPan,HaoWu,YunDing,Mei-HuaShen*,Xian-HuaPan.SubstituentEnabledDivergentSynthesisofN-Heterocycles:aMetalCarbeneApproachInvolvingIntramolecularCarbeneInterception.AsianJ.Org.Chem.2014,3(11),1154-1158. 18.Hua-DongXu*,Zhi-HongJia,KeXu,MeiHan,Sai-NanJiang,JingCao,Jia-ChengWang,Mei-HuaShen*.Copper-CatalyzedCyclization/aza-ClaisenRearrangementCascadeInitiatedbyKetenimineFormation:AnEfficientStereocontrolledSynthesisofα-AllylCyclicAmidines.Angew.Chem.,Int.Ed.2014,53(35),9284-9288.(Publishedonline:July2,2014) 19.Hua-DongXu*,Mao-QiangCai,Wei-JieHe,Wen-HaoHu,Mei-HuaShen*.Interceptionofbenzynewiththioethers:afacileaccesstosulfurylidesundermildconditions.RSCAdv.2014,4(15),7623-7626. 20.Hua-DongXu*,Ren-WeiZhang,XiaoxunLi,SuyuHuang,WeipingTang,Wen-HaoHu.Rhodium-CatalyzedChemo-andRegioselectiveCross-DimerizationofTwoTerminalAlkynes.Org.Lett.2013,15(04),840-843. 21.NaLiu,Hao-YuanWang,WeiZhang,Zhi-HongJia,IliaA.Guzei,Hua-DongXu*,WeipingTang*.StereoselectiveHalocyclizationofAlkenesWithN-AcylHemiaminalNucleophiles.Chirality2013,25(11),805-809.

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