个人简介
PROFESSIONALEXPERIENCE(工作经历):
2010-presentProfessorofChemistry
SchoolofPharmaceuticalandLifeSciences,ChangzhouUniversity,China.
(常州大学制药学院,教授)
2004-2010DirectorofSmallMoleculeSynthesisFacility&AssistantResearchProfessor
DepartmentofChemistry,DukeUniversity,NorthCarolina,USA.
(美国杜克大学化学系,研究助教授，小分子合成中心主任)
2001-2003SeniorResearchScientist
TransTechPharmaInc.,NorthCarolina,USA.
(美国TransTechPharma制药公司,资深科学家)
2000-2001PostdoctoralResearchAssociate
DepartmentofChemistry,DukeUniversity,NorthCarolina,USA
(美国杜克大学化学系,博士后)
1997-1999PostdoctoralFellow
DepartmentofEntomology,UniversityofCalifornia,Riverside,California,USA
(美国加州大学河滨分校昆虫学系,博士后)
1995-1997AssociateProfessor
DepartmentofChemistry,TsinghuaUniversity,Beijing,China
(清华大学化学系,副教授)
1993-1995PostdoctoralResearcher
DepartmentofChemistry,TsinghuaUniversity,Beijing,China
(清华大学化学系,博士后)
TEACHINGEXPERIENCE(授课经历):
·“MedicinalChemistry药物化学”(forundergraduatestudents,2011-2016)
ChangzhouUniversity,China.
·“FDARegulationsforNewDrugs新药认证”(forundergraduatestudents,2010-2014)
ChangzhouUniversity,China.
·“NewDrugsR&D新药研究与开发”(forgraduatestudents,2011-2016)
ChangzhouUniversity,China.
·“DesignofOrganicMolecules有机分子设计”(forundergraduatestudents,1995-1997)
TsinghuaUniversity,China.
·“OrganicSynthesis有机合成”(forgraduatestudents,1995-1997)
TsinghuaUniversity,China.
EDUCATIONBACKGROUND(教育背景):
1993,Ph.D.(Major:syntheticorganicchemistry),LanzhouUniversity,China.
(博士，兰州大学化学系)Advisor:YulinLi
1990,M.Sc.(Major:organicchemistry),LanzhouUniversity,China.
(硕士，兰州大学化学系)Advisor:ZiyiZhang
1987,B.Sc.(Major:organicchemistry),LanzhouUniversity,China.
(学士，兰州大学化学系)
AWARDSANDRECOGNITIONS(获奖荣誉):
1、InternationalTechnologyCooperationCertificateofAward,CPCIF(China’sPetroleumandChemicalIndustryFederation),2017
(中国石油和化学工业联合会国际科技合作奖,2017)
2、Scienceandtechnologyprogressprize(firstplace),ChangzhouCityGovernment,China(2015)
(常州市科技进步奖一等奖,2015)
3、OutstandingResearcherofJiangsuProvince(2014)
(第11届江苏省优秀科技工作者,2014)
4、Top-TenExcellentResearchersofChangzhouCity(2014)
(常州市十佳科技工作者,2014)
5、TeamawardofexcellentadvisorforundergraduatethesisofJiangsuProvince(2012)
(2012年度江苏省高校本专科优秀毕业设计(论文)优秀毕业设计团队奖)
6、Second-leveltalentedscientistof“333High-levelTalentTrainingProgram”ofJiangsuProvince
(江苏省“333高层次人才培养工程”第二层次培养对象)(2011-2015)
7、InnovativeandentrepreneurialtalentofJiangsuProvince(2010)
(江苏省“双创人才”)
8、Scienceandtechnologyleaderof“831TalentTrainingProgram”ofChangzhouCity(2009)
(常州市“831高层次人才培养工程”首批中青年科学技术带头人)
FUNDINGS(基金课题):
1.JiangsuProvincialAgriculturalShan-XinProgramproject(grantNo.SXGC[2016]070):“Integratedinnovationandapplicationofgreencontroltechnologyofpearandpeachpests”(2016-2017,PI).
江苏省农业三新工程项目(代号SXGC[2016]070):“桃梨害虫绿色防控技术的集成创新及应用示范”(2016-2017，主持)。
2.NationalScienceFoundationofChinaproject(grantNo.21272029):“StudyonnovelinhibitorsoftypeIIIsecretionsystemforPseudomonasaeruginosa”(2013-2016,PI)
国家自然科学基金面上项目(代号21272029):“绿脓杆菌III型分泌系统的新抑制剂研究”(2013-2016，主持)。
3.NationalScienceFoundationofChinaproject(grantNo.81272982):“Structure-activityrelationshipstudyofGarcinolfororalcancerchemoprevention”(2013-2016,Co-PI)
国家自然科学基金面上项目(代号81272982):“山竹醇在口腔癌化学预防中的构效关系研究”(2013-2016，合作主持)。
4.Sino-USAinternationalcollaborativeproject:“SynthesisandscreeningofnewinhibitorsagainstT3SSofpathogens”(2012-2014,PI)
国际合作项目:“病原菌III型分泌系统新抑制剂的合成和筛选”(2012-2014，主持)。
5.TechnologySupportingProgramofJiangsuProvinceproject:“Efficientsexpheromonetechnologyanditsapplicationforpollution-controllingmanagementofvegetablepests”(2012-2014,PI)
江苏省科技支撑计划项目:“无公害防治蔬菜害虫的高效生物信息素技术及应用开发”(2012-2014，主持)
近期论文
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1.LeiJin,ShuaiZhao,XinChen*.Synthesisofbothenantiomersofchiralphenylalaninederivativescatalyzedbycinchonaalkaloidquaternaryammoniumsaltsasasymmetricphasetransfercatalysts.Molecules,2018,23,1421.
2.KaichengMeng,PaulShim,QingtinWang,ShuaiZhao,TingGu,AlemW.Kahsai,SeungkirlAhn,XinChen*.Design,synthesis,andfunctionalassessmentofCmpd-15derivativesasnegativeallostericmodulatorsfortheβ2-adrenergicreceptor.Bioorg.Med.Chem.2018,26,2320-2330.
3.XiangyuLiu,SeungkirlAhn,AlemW.Kahsai,Kai-ChengMeng,NaomiR.Latorraca,BiswaranjanPani,A.J.Venkatakrishnan,AliMasoudi,WilliamI.Weis,RonO.Dror,XinChen,RobertJ.Lefkowtiz*,BrianK.Kobilka*.Mechanismofintracellularallostericβ2ARantagonistrevealedbyX-raycrystalstructure.Nature,2017,548,480-484.
4.SeungkirlAhn,AlemW.Kahsai,BiswaranjanPani,Qin-TingWang,ShuaiZhao,AlissaL.Wall,RyanT.Strachan,DeanP.Staus,LauraM.Wingler,LillianD.Sun,JustineSinnaeve,TedCho,GwennM.Hansen,MichaelB.Burnett,JaneLamerdin,DanielBassoni,BryantGavino,GitteHusemoen,EvaK.Olsen,ThomasFranch,StefanoCostanzi,XinChen*,RobertJ.Lefkowitz*.Anallosteric“Beta-Blocker”discoveredfromaDNA-encodedsmallmoleculelibraries.Proc.Natl.Acad.Sci.USA,2017,114(7),1708-1713.
5.ThomasJ.CahillIII,AlexR.B.Thomsen,JeffreyT.Tarrasch,BiancaPlouffe,AnthonyH.Nguyen,FanYang,Li-YinHuang,AlemW.Kahsai,DanielL.Bassoni,BryantGavino,JaneLamerdin,SarahTriest,ArunK.Shukla,BenjaminBerger,JohnLittleIV,AlbertAntar,AdiBlanc,Chang-XiuQu,XinChen,KoukiKawakami,AsukaInoue,JunkenAoki,JanSteyaert,Jin-PengSun,MichelBouvier,GeorgiosSkiniotis,RobertJ.Lefkowitz*.DistinctconformationsofGPCR-β-arrestincomplexesmediatedesensitization,signalingandendocytosis.Proc.Natl.Acad.Sci.USA,2017,114(10),2562-2567.
6.KaiXu,ShuaiZhao,Jia-KuanXu,*Ming-WeiShan,Jia-LiYu,Yu-BoWang,Cheng-FangZhang,XinChen*.Totalsynthesisof(3Z,9Z,6S,7R)-and(3Z,9Z,6R,7S)-6,7-epoxy-3,9-octadecadienes.Synth.Commun.2017,47(20),1848-1853.
7.Xin-YingZhou,JingCao,Chao-MingHan,Shu-WenLi,ChenZhang,Yin-DuanDu,Qian-QianZhou,Xin-YanZhang*,XinChen*.TheC8sidechainisoneofthekeyfunctionalgroupofgarcinolforitsanti-cancereffects.Bioorg.Chem.2017,71,74-80.
8.PunitaKumari,AshishSrivastava,RamanujBanerjee,EshanGhosh,PragyaGupta,RaviRanjan,XinChen,BhagyashriGupta,CharuGupta,DeepikaJaiman,ArunK.Shukla*.FunctionalcompetenceofapartiallyengagedGPCR-β-arrestincomplex.NatureCommunications,2016,7,13416.
9.ChenLu,QiangZhang,XinChen*.NewmethodforsynthesisofEZH2methyltransferaseinhibitorGSK126.Synth.Commun.2016,46,1215-1222.
10.LinglingGu,ShanshanZhou,LanpingZhu,CuirongLiang,XinChen*.Small-moleculeinhibitorsofthetypeIIIsecretionsystem.Molecules,2015,20,17659-17674.
11.Chao-MingHan,Xin-YingZhou,JingCao,Xin-YanZhang*,XinChen*.13,14-Dihydroxygroupsarecriticalfortheanti-cancereffectsofgarcinol.Bioorg.Chem.2015,60,123-129.
12.YanLi,WilliamHutchins,XiaogangWu,CuirongLiang,ChengfangZhang,XiaochenYuan,DevanshiKhokhani,XinChen,YizhouChe,QiWang*,Ching-HongYang*.DerivativesofplantphenoliccompoundinhibitsthetypeIIIsecretionsystemofDickeyadadantiiviaHrpX/HrpYtwo-componentsignaltransductionandRsmsystem.MolecularPlantPathology,2015,16(2),150-163.
13.ArunK.Shukla,GerwinH.Westfield,KunhongXiao,RosanaI.Reis,Li-YinHuang,PrachiTripathi-Shukla,JiangQian,ShengLi,AdiBlanc,AustinN.Oleskie,AnneM.Dosey,MinSu,Cui-RongLiang,Ling-LingGu,Jin-MingShan,XinChen,RachelHanna,MinjungChoi,XiaoJieYao,BjoernU.Klink,AlemW.Kahsai,SachdevS.Sidhu,PawelA.Penczek,ShoheiKoide,AnthonyA.Kossiakoff,VirgilL.WoodsJr.,BrianK.Kobilka*,GeorgiosSkiniotis*,RobertJ.Lefkowitz*.VisualizationofarrestinrecruitmentbyaGprotein-coupledreceptor.Nature,2014,512,218-222.
14.CuirongLiang,LinglingGu,Yang,XinChen*.AlternatesynthesisofHSP90inhibitorAT13387,Synth.Commun.2014,44,2416-2425.
15.Yu-HuiLuo,Feng-XiaYue,Xiao-YangYu,XinChen*,HongZhang*.Coordinationpolymersoflanthanidecomplexeswithbenzenedicarboxylatoligands.CrystEngComm,2013,15,6340-6348.
16.Yu-HuiLuo,Feng-XiaYue,Xiao-YangYu,Ling-LingGu,HongZhang*,XinChen*.AseriesofentangledZnII/CdIIcoordinationpolymersconstructedfrom1,3,5-benzenetricarboxylateacidandflexibletriazoleligands.CrystEngComm,2013,15,8116-8124.
17.Zheng-YiLi,Hong-ZhaoMa,ChenHan,Hai-TaoXi,QiMeng,XinChen*,Xiao-QiangSun*.Synthesisofisothiocyanatesbyreactionofamineswithphenylchlorothionoformateviaone-potortwo-stepprocess.Synthesis,2013,45,1667-1674.
18.DevanshiKhokhani,ChengfangZhang,YanLi,QiWang,QuanZeng,AkihiroYamazaki,WilliamHutchins,Shan-ShanZhou,XinChen*,Ching-HongYang*.DiscoveryofplantphenoliccompoundsthatactastypethreesecretionsysteminhibitorsorinducersoffireblightpathogenErwiniaamylovora.AppliedandEnvironmentalMicrobiology,2013,79,5424-5436.
19.KunHu，Yan-JieQi，JuanZhao，He-FeiJiang，XinChen*，JieRen*.Synthesisandbiologicalevaluationofnovelsulforaphanederivativesaspotentialantitumoragents.Eur.J.Med.Chem.2013,64,529-539
20.JieRen,JuanZhao,Yong-ShengZhou,Xian-HuaLiu,XinChen*,KunHu*.Synthesisandantitumoractivityofnovel4-aminoquinolinederivatives.MedicinalChemistryResearch,2013,22,2855-2861.
21.XinChen,XinyanZhang,YeLu,Joong-YounShim,ShengminSang,ZhengSun*,XiaoxinChen*.Chemopreventionof7,12-dimethylbenz[a]anthracene(DMBA)-inducedHamsterCheekPouchCarcinogenesisbya5-LipoxygenaseInhibitor,Garcinol.Nutrition&Cancer2012,64,1211-1218.
22.JieRen,HongCheng,WenQunXin,XinChen*,KunHu*.Inductionofapoptosisby7-piperazinethylchrysininHCT-116humancoloncancercells.OncologyReports,2012,28,1719-1726.
23.JieRen,Hua-JinXu,HongCheng,Wen-QunXin，XinChen*,KunHu*.SynthesisandantitumoractivityofFormononetinnitrogenmustardderivatives.Eur.J.Med.Chem.2012,54,175-187.
24.KunHu,LinWu,Wen-QunXin,XinChen*,JieRen*.Synthesisandbiologicalevaluationofanticanceractivityfornovel4β-aminooxadiazolederivativesofpodophyllotoxin.Bioorg.Med.Chem.Lett.2012,22,4778-4782.
25.AkihiroYamazaki,JinLi,QuanZeng,DevanshiKhokhani,WilliamC.Hutchins,AngelaC.Yost,EulandriaBiddle,EricJ.Toone,XinChen*,Ching-HongYang*.DerivativesofplantphenoliccompoundaffectthetypeIIIsecretionsystemofPseudomonasaeruginosaviaaGacS/GacAtwocomponentsignaltransductionsystem.Antimicrob.AgentsChemother.2012,56,36-43.
26.XinChen*,ZhengyiLi,XiaoqiangSun,HongzhaoMa,XiaoxinChen,JieRen,KunHu.Newmethodforsynthesisofsulforaphaneandtherelatedisothiocyanates.Synthesis,2011,3991-3996.
27.BidongD.Nguyen,DoreenF.Cunningham,XiaofeiLiang,XinChen,EricJ.Toone,ChristianR.H.Raetz,PeiZhou,RaphaelH.Valdivia*.LipooligosaccharideisrequiredforthedevelopmentaltransitionofreplicativeReticulateBodiestoinfectiousElementaryBodiesinChlamydiatrachomatis.Proc.Natl.Acad.Sci.USA,2011,108,10284-10289.
28.ChuljinLee,XiaofeiLiang,XinChen,DainaZeng,SangHoonJoo,HakSukChung,AdamW.Barb,ShaunaM.Swanson,RobertA.Nicholas,YaoxianLi,EricJ.Toone*,ChrisRaetz*,PeiZhou*.Species-specificandInhibitor-dependentConformationsofLpxC--ImplicationforAntibioticDesign.Chemistry&Biology,2011,18,38-47.
29.XiaofeiLiang,Chul-JinLee,XinChen,HakSukChung,DainaZeng,ChristianR.H.Raetz,YaoxianLi,PeiZhou*,EricJ.Toone*.Syntheses,StructuresandAntibioticActivitiesofLpxCInhibitorsBasedontheDiacetyleneScaffold.Bioorg.Med.Chem.2011,19,852-860.
30.WarrenS.Warren*,ElizabethJenista,RosaTamaraBranca,XinChen.Increasinghyperpolarizedspinlifetimesthroughtruesingleteigenstates.Science,2009,323,1711-1714.
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