个人简介
一、教育背景
2001.9-2005.6福州大学,国家理科化学基地班,理学学士
2007.9-2010.6福州大学,药学,医学硕士
2010.9-2013.9南京大学,化学,理学博士
二、工作经历
2014.1-2014.12南京财经大学管理科学与工程学院,讲师
2015.1-2017.8中国科学院福建物质结构研究所,博士后
2017.9-2018.11福建师范大学生命科学学院,讲师
2018.12-至今福建师范大学生命科学学院,副研究员五、专利
1.龚睿,张怀东,一种靶向埃博拉病毒囊膜蛋白的高亲和力单域抗体及其制备方法与应用,CN108191973A(公开)
2.龚睿,张怀东,一种中和新疆出血热病毒的单域抗体,CN106188285A(公开)
研究领域
(1)金属药物研究
金属拥有众多外层电子,与有机基团结合形成多样的拓扑结构,拥有丰富的生物活性。研究金属离子作为活性中心或者激活中心,与生物大分子的结合及其结合位点、作用方式等问题,并以此为基础设计活性金属分子,合成纳米载药系统,开发重大疾病相关的药物。
(2)多模(FL/MRI/CT)成像研究
生物分子间通过空间结构的变化发生相互作用,是发挥生理功能的基础,动态观察这些变化过程是揭示生理机制的重要手段。研究设计合成多模纳米平台,结合不同成像技术的优势,实现实时无损成像,提高医药诊断精准度。
近期论文
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1.F.N.Xiao#,Y.Xiao#,F.M.Chen,X.L.Liu,C.T.Lin,J.X.Chen,Y.K.Wu*,FacilesynthesisofSiliconquantumdot-Gadolinium:Apotentialfluorescent/T1-T2multimodalimagingagent,Talanta,2019.02.04,199(1):336-346.
2.F.M.Chen#,F.N.Xiao#,W.B.Zhang,C.T.Lin,Y.K.Wu*,HighlyStableandNIRLuminescentRu-LPMSNHybridMaterialsforSensitiveDetectionofCu2+inVivo,ACSApplMaterInterfaces,2018.8.15,10(32):26964-26971.
3.F.N.Xiao#,X.L.Liu#,Y.Xiao,F.M.Chen,Y.K.Wu*,AluminescentlayeredhybridAg-Ru/LDHasaphotocatalyticantibacterialagent,NewJournalofChemistry,2017.8.7,41(15):7260-7266.
4.Y.D.Liu,X.L.Liu,Y.Xiao,F.M.Chen,F.N.Xiao*,Amultifunctionalnanoplatformbasedonmesoporoussilicananoparticlesforimaging-guidedchemo/photodynamicsynergetictherapy,RSCAdvances,2017,7(49):31133-31141.
5.F.N.Xiao,K.Wang,F.B.Wang,X.H.Xia*,HighlyStableandLuminescentLayeredHybridMaterialsforSensitiveDetectionofTNTExplosives,AnalyticalChemistry,2015.4.21,87(8):4530-4537.
6.F.N.Xiao,M.Wang,F.B.Wang,X.H.Xia*,Graphene-Ruthenium(II)ComplexCompositesforSensitiveECLImmunosensors,Small,2014,10,706-716.(Frontispiecepaper)
7.H.S.Wang,F.N.Xiao,Z.Q.Li,J.Ouyang,Z.Q.Wu,X.H.Xia*,G.J.Zhou*,SensitiveDeterminationofReactiveOxygenSpeciesinCigaretteSmokeUsingMicrochipElectrophoresis-LocalizedSurfacePlasmonResonanceEnhancedFluorescenceDetection,LabonChip,2014,14,1123-1128.
8.H.S.Wang,C.Wang,Y.K.He,F.N.Xiao,W.J.Bao,X.H.Xia*,G.J.Zhou*,Core-ShellAg@SiO2NanoparticlesConcentratedonaMicro/NanofluidicDeviceforSurfacePlasmonResonance-EnhancedFluorescentDetectionofHighlyReactiveOxygenSpecies,Anal.Chem.,2014,86,3013-3019.
9.M.Wang,F.N.Xiao,K.Wang,F.B.Wang,X.H.Xia*,ElectricFieldDrivenProtonation/Deprotonationof3,4,9,10-PeryleneTetracarboxylicAcidimmobilizedonGraphenesheetsviaπ-πStacking,J.Electroanal.Chem.,2013,688,304-307.
10.B.Zheng,T.W.Chen,F.N.Xiao,W.J.Bao,X.H.Xia*,KOH-activatednitrogen-dopedgraphenebymeansofthermalannealingforsupercapacitor,J.SolidStateElectrochem.,2013,17,1809-1814.
11.M.Wang,G.X.Wang,F.N.Xiao,Y.Zhao,K.Wang,X.H.Xia*,SensitiveLabel-FreeMonitoringofProteinKinaseActivityandInhibitionUsingFerricIonsCoordinatingtoPhosphorylatedSitesAsElectrocatalysts,Chem.Commun.2013,49,8788-8790.
12.J.Li,F.N.Xiao,X.H.Xia*,One-stepimmobilizationofRu(bpy)32+inasilicamatrixfortheconstructionofasolid-stateelectrochemiluminescentsensorwithhighperformance,Analyst,2012,137,5245-5250.
13.Q.H.Wei*,F.N.Xiao,L.J.Han,S.L.Zeng,Y.N.Duan,G.N.Chen*,Synthesis,structure,photophysicalandelectrochemiluminescencepropertiesofRe(I)tricarbonylcomplexesincorporatingpyrazolyl–pyridyl-basedligands,DaltonTrans.,2011,40,5078-5085.
14.Q.H.Wei*,Y.F.Lei,Y.N.Duan,F.N.Xiao,M.J.Li,G.N.Chen*,Mono-anddinuclearRu(II)complexesof1,4-bis(3-(2-pyridyl)pyrazol-1-ylmethyl)benzene):Synthesis,structure,photophysicalpropertiesandelectrochemiluminescentdeterminationofdiureticfurosemide,DaltonTrans.,2011,40,11636-11642.