王德民 - 福建师范大学 - 生命科学学院

个人简介

个人简介：教授，博士生导师。美国JohnB&JudithAGardetto癌症研究终身讲席教授。教育经历： 1988年南京大学学士、1995年美国田纳西大学博士。工作经历： 1995-2000美国StJude儿童研究医院生化部博士后。 2000-2004美国威斯康星血液研究所副研究员(助理教授)。 2004-2009美国威斯康星血液研究所研究员(副教授)。 2009-2016美国威斯康星血液研究所高级研究员(教授) 2003-2016南京大学生命科学学院兼职教授 2013-现在美国JohnBandJudithAGardetto癌症研究终身讲席教授。 2016-现在福建师范大学生命科学学院教授国际学术会议： 2005美国芝加哥第三十四届年度秋季免疫学会议，B细胞激活和通路讨论会主席 2007组织中国南京分子免疫学国际研讨会 2008组织中国南京分子免疫学国际研讨会 2009组织中国丽江第三届国际传染病和免疫研讨会 2012美国芝加哥B第41届年度秋季免疫学会议细胞发育研讨会主席 2013美国威斯康星州第7届年度人类免疫学研讨会中心委员会共同主席 2013美国血液学会美国血液学会，淋巴细胞,淋巴细胞活化和免疫缺陷,包括艾滋病毒和其他感染:B细胞和先天免疫细胞研讨会共同主席。 2014美国威斯康星州第8届年度人类免疫学研讨会委员会主席。获奖： 2003-2007美国癌症学会研究奖 2007-2012美国白血病和淋巴瘤学会学者奖审稿专家： NatureReviewsImmunology,ProceedingsoftheNationalAcademyofSciences,Blood,MolecularandCellularBiology,JournalofBiologicalChemistry,JournalofImmunology,Oncogene,etal。基金评审专家： 2004Adhocreviewer,theNationalScienceFoundation（美国国家科学基金会） 2006Member,ZAI1PA-IS2,SpecialEmphasisPanel,NIAID,NIH(美国国家卫生部) 2007Adhocreviewer,Allergy,Immunology,andTransplantationResearchCommittee(AITRC),NIAID,NIH(美国国家卫生部) 2007Member,ZAI1-SV-I-S1,SpecialEmphasisPanel,NIAID,NIH(美国国家卫生部) 2009Adhocreviewer,HematopoiesisStudySection,NHLBI,NIH(美国国家卫生部) 2010Member,ZRG1-VH-F02M,HematopoieticCellularMechanismsSpecialEmphasisPanel,NHLBI,NIH(美国国家卫生部) 2010Adhocreviewer,MolecularandCellularHematologyStudySection,NIH(美国国家卫生部) 2011Member,AmericanCancerSociety,Leukemia,ImmunologyandBloodCelldevelopmentStudySection(美国肿瘤协会) 2011Member,ZRG1VH-C,SpecialEmphasisPanel,NHLBI,NIH(美国国家卫生部) 2011Adhocreviewer,theLeukemiaResearchFoundation（美国国家科学基金会） 2006-2015Member,MedicalCollegeofWisconsinCancerCenterGrant（美国威斯康星医学院） 2012Member,theNewYorkStateDepartmentofHealth’sStemCellScienceProgram（纽约州卫生部干细胞科学计划） 2012Adhocreviewer,AmericanSocietyofHematology(ASH),Atlanta,GA,2012 2011-2015Regularmember,Molecular&CellularHematologyStudySection,NIH(美国国家卫生部)

研究领域

研究免疫系统中淋巴细胞发育和功能的生物学及信号传导的分子调控机理，以及研究造血干细胞的功能和分子调控机理。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

(Publicationsselectedfrom78publications) QuelleFW,WangD,NosakaT,ThierfelderWE,StravopodisD,WeinsteinYandIhleJN.Erythropoietininducesactivationofstat5throughassociationwithspecifictyrosinesonthereceptorthatarenotrequiredforamitogenicresponse.Mol.Cell.Biol.16:1622-1631,1996. WangD,StravopodisD,TeglundS,KitazawaJ,andIhleJN.Naturallyoccurringdominantnegativevariantsofstat5.Mol.Cell.Biol.1996;16:6141-6148. QuelleFW,WangJ,FengJ,WangD,ClevelandJM,IhleJN,andZembettiGP.Cytokinerescueofp53-dependentapoptosisandcellcyclearrestismediatedbydistinctJAKkinasesignalingpathways.GenesDev.1998;12:1099-1107. TeglundS,McKayC,SchuetzE,vanDeursenJM,StravopodisD,WangD,BrownM,BodnerS,GrosveldG,andIhleJN.Stat5AandBproteinshaveessentialandnon-essential,orredundant,rolesincytokineresponse.Cell1998;93:841-850. ParganasE,WangD,StravopodisD,TophamDJ,MarineJC,TeglundS,VaninEF,BodnerS,ColarnoniciOR,vanDeursenJM,GrosveldG,andIhleJN.Jak2isessentialforsignalingthroughavarietyofcytokinereceptors.Cell1998;93:385-395. MorigglR,TophamDJ,TeglundS,SexlV,McKayC,WangD,HoffmeyerA,vanDeursenJ,SangsterMY,BuntingKD,GrosveldGC,andIhleJN.Stat5isrequiredforIL-2-inducedcellcycleprogressionofperipheralTcells.Immunity1999;10:249-259. ChengM,WangD,andRousselMF.Expressionofc-Mycinresponsetocolony-stimulatingfactor-1requiresmitogen-activatedproteinkinasekinase-1.J.Biol.Chem.1999;274:6553-6558. MarineJC,McKayC,WangD,TophamDJ,ParganasE,NakajimaA,PendevilleH,YasukawaH,SasakiA,YoshimuraA,andIhleJN.SOCS-IIIisessentialintheregulationoffetallivererythropoiesis.Cell1999;98:617-627. MarineJC,TophamDJ,McKayC,WangD,ParganasE,StravopodisD,YoshimuraA,andIhleJN.SOCS-1deficiencycausesalymphocytedependentperinatallethality.Cell1999;98:609-616. WangD,MorigglR,StravopodisD,CarpinoN,MarineJC,TeglundS,FengJ,andIhleJN.Asmallamphipathicα-helicalregionisrequiredfortranscriptionalactivitiesandproteosome-dependentturnoverofthetyrosinephosphorylatedStat5.EMBOJ.2000;19:392-399. SchwallerJ,ParganasE,WangD,CainD,AsterJC,WilliamsIR,LeeCK,GerthnerR,KitamuraT,FrantsveJ,AnastasiadouE,ML,LevyDE,IhleJN,GillilandGD.Stat5isessentialforthemyelo-andlympho-proliferativediseaseInducedbyTEL/JAK2throughregulationofOncostatinM.MolecularCell2000;6:693-704. WangD,FengJ,WenR,MarineJC,SangsterMS,ParganasE,HoffmeyerA,JacksonCW,ClevelandJM,MurrayPJ,andIhleJN.PhospholipaseC2isessentialinthefunctionsofBcellandseveralFcReceptors.Immunity,2000;13:25-35. WenR,WangD,McKayC,BuntingKD,MarineJC,ZembettiGP,IhleJN,andClevelandJM.Jak-3providesasurvivalsignaldownstreamofIL-7signalingpathway.Mol.Cell.Biol.2001;21:678-689. WenR,JouS,ChenY,HoffmeyerAandWangD.PhospholipaseC2isessentialforspecificfunctionsofFcRandFcR.J.Immunol.2002;169:6743-6752. JouS,CarpinoN,TakahashiY,PiekorzR,ChaoJ,CarpinoN,WangDandIhleJN.Anessential,non-redundantroleforthephosphoinositide3-kinasep110dinsignalingbytheBCellreceptorcomplex.Mol.Cell.Biol.2002;22:8580-8591. ChoMJ,LiuJ,PestinaTI,StewardSA,ThomasDW,CoffmanTM,WangD,JacksonCW,andGartnerTK.TherolesofIIb3-mediatedoutside-insignaltransduction,thromboxaneA2,andadenosinediphosphateincollagen-inducedplateletaggregation.Blood2003;101:2646-2651. ChenY,WenR,YangS,SchumanJ,ZhangEE,YiT,FengGSandWangD.IdentificationofShp-2asaStat5Aphosphatase.J.Biol.Chem.2003;278:16520-16527. XueL,MorrisSW,OrihuelaC,TuomanenE,CuiX,WenRandWangD.DefectivedevelopmentandfunctionofBcl10-deficientfollicular,marginalzoneandB1Bcells.NatureImmunology2003;4:857-865. WenR,ChenY.,XueL,SchumanJ,YangS,MorrisSWandWangD.PhospholipaseC2providessurvivalsignalsviaBcl-2andA1indifferentsubpopulationsofBcells.J.Biol.Chem.2003;278:43654-43662. ZhuY,ChenL,HuangZ,AlkanS,BuntingKD,WenR,WangD,andHuaHuang.IL-5primesTh2cytokine-producingcapacityineosinophilsthroughaSTAT5-dependentmechanism.J.Immunol.2004;173:2918-2922. WenR,ChenY,SchumanJ,YangS,NewmanDandWangD.AnimportantroleofphospholipaseCg1inpre-B-celldevelopmentandallelicexclusion.EMBOJ.2004;23:4007-4017. MorigglR,SexlV,KennerL,DuntschC,StanglK,GingrasS,HoffmeyerA,BauerA,PiekorzR,WangD,etal.Stat5tetramerformationisassociatedwithleukemogenesis.CancerCell2005;7:87-99. RegunathanJ,ChenY,WangDandMalarkannanS.NKG2D-mediatedNKcellcytotoxicityisregulatedbyInhibitoryLy49Receptors.Blood2005;105:233-240. ZhuM,GranilloO,WenR,YangK,DaiX,WangD,andZhangW.NegativeregulationoflymphocyteactivationbytheadaptorproteinLAX.J.Immunol.2005;174:5612–5619. MutsumotoR,WangD,BlonskaM,LiH,KobayashiM,PappuB,ChenY,WangD,LinX.PhosphorylationofCARMA1playsacriticalroleinTcellreceptor-mediatedNF-Bactivation.Immunity2005;23:575-585. DaiX,ChenY,SchumanJ,HuaZ,AdamsonJW,WenR,WangD.DistinctrolesofPI3KandPLC2inBcellreceptor-mediatedsignaltransduction.Mol.Cell.Biol.2006;26:88-99. CheesemanKL,KashiwagiK,MichaudT,UeyamaT,WangD,FlaxLA,ShiraiY,LoegeringDJ,SaitoN,andLennartzMR.TargetingofPKC-εduringFcγR-dependentphagocytosisrequirestheεC1BdomainandphospholipaseC-γ1.Mol.Biol.Cell.2006;17:799-813. XuW,FukuyamaT,NeyPA,WangD,RehgJ,BoydK,vanDeursenJM,andBrindlePK.GlobaltranscriptionalcoactivatorsCREB-bindingproteinandp300arehighlyessentialcollectivelybutnotindividuallyinperipheralB-cells.Blood2006;107:4407-4416. ChenY,DaiX,HaasAL,WenR,WangD.Proteasome-dependentdown-regulationofactivatedStat5Ainthenucleus.Blood108:566-574,2006. RegunathanJ,ChenY,KutlesaS,DaiX,BaiL,WenR,WangD*,andMalarkannanS*.Differentialandnon-redundantrolesofPLCγ2andPLCγ1intheterminalmaturationofNKcells1.J.Immunol.2006;177:5365-5376.(*equalseniorauthorship). HoekKL,AntonyP,LoweJ,ShinnersN,SarmahB,WenteSR,WangD,GersteinRMandKhanWN.TransitionalBcellfateisassociatedwithdevelopmentalstage-specificregulationofdiacylglycerolandcalciumsignalinguponBcellreceptorengagement.J.Immunol.2006;177:5405-5413. WenR,ChenY,FuG,SchumanJ,YangC,StephanRP,ClevelandJLandWangD.AnessentialroleofphospholipaseCg2inearlyBcelldevelopmentandMyc-mediatedlymphomagenesis.Mol.Cell.Biol.2006;26:9364–9376. ChenY,PappuB,ZengH,XueL,MorrisSW,LinX,WenRandWangD.Bcl10isessentialforFcR-mediateddegranulationandIL-6productioninmastcells.J.Immunol.2007;178:49-57. BlonskaM,PappuBP,MatsumotoR,LiH,SuB,WangD,andLinX.TheCARMA1-Bcl10SignalingComplexSelectivelyRegulatesJNK2KinaseintheTCellReceptor-SignalingPathway.Immunity2007;26:55-66. YangXO,PanopoulosAD,NurievaR,ChangSH,WangD,WatowichSS,andDongC.STAT3regulatescytokine-mediatedgenerationofinflammatoryhelperTcells.J.Biol.Chem.2007;282:9358-9363. ZhouM,McPhersonL,FengD,SongA,DongC,LyuSC,ZhouL,ShiX,AhnYT,WangD,ClaybergerCandKrenskyAM.KLF13regulatesTlymphocytesurvivalinvivo.J.Immunol.2007;178:5496-5504. MisraRS,RussellJQ,KoenigA,Hinshaw-MakepeaceJA,WenR,WangD,HuoH,LittmanDR,FerchU,RulandJ,ThomeMandBuddRC.Caspase-8andc-FLIPLassociateinlipidraftswithNF-kBadaptorsduringTcellactivation.J.Biol.Chem.2007;282:19365-19374. DaiX,ChenY,DiL,PoddA,LiG,BuntingKD,HennighausenL,WenRandWangD.Stat5isessentialforearlyBcelldevelopmentbutnotforBcellmaturationandfunction.J.Immunol.2007;179:1068-1079. BaiL,ChenY,HeY,DaiX,LinX,WenRandWangD.PhospholipaseC2contributestolightchaingeneactivationandreceptorediting.Mol.Cell.Biol.2007;27:5957-5967. MalarkannanS,RegunathanJ,ChuH,ChenY,ZengH,KutlesaS,WenRandWangD.ActivationofBcl10isessentialforthesignalingdivergenceofNKG2D-mediatedcytotoxicityandcytokinegenerationinNKcells.J.Immunol.2007;179:3752-3762. ShinnersNP,CarlessoG,CastroI,HoekK,CornR,WoodlandR,ScottML,WangDandKhanWN.Bruton’styrosinekinasemediatesNF-BactivationandBcellsurvivalbyBcellactivatingfactoroftheTNFfamily.J.Immunol.2007;179:3872-3880. ChenY,YuM,PoddA,WenR,Chrzanowska-WodnickaM,WhiteGC,andWangD.AcriticalroleofRap1binBcelltraffickingandmarginalzoneBcelldevelopment.Blood2008;111:4627-4636. ZengH,ChenY,YuM,XueL,GaoX,MorrisSW,WangD,andWenR.TCR-mediatedactivationofCD4+CD44hiTcellsbypassesBcl10.J.Biol.Chem.2008;283:24392-24399. ChenY,WangX,DiL,FuG,ChenY,BaiL,LiuJ,FengX,McDonaldJM,MichalekS,HeY,YuM,FuYX,WenR,WuHandWangD.PhospholipaseC2mediatesRANKL-stimulatedlymph-nodeorganogenesisandosteoclastogenesis.J.Biol.Chem.2008;283:29593-29601. SchulteisRD,ChuH,DaiX,ChenY,EdwardsB,HaribhaiD,WilliamsCB,MalarkannanS,HessnerMJ,Glisic-MilosavljevicS,JanaS,KerschenEJ,GhoshS,WangD,etal.ImpairedsurvivalofperipheralTcells,disruptedNK/NKTcelldevelopment,andliverfailureinmicelackinggimap5.Blood2008;112:4905-4914. OhmoriK,LuoY,JiaY,NishidaJ,WangZ,BuntingKD,WangD,andHuangH.IL-3inducesbasophilexpansioninvivobydirectinggranulocyte-monocyteprogenitorstodifferentiateintobasophillineage-restrictedprogenitorsinthebonemarrowandbypromotingbasophil/mastcellcommonprogenitorstodifferentiateintobasophilsinthespleen.J.Immunol.2009;182:2835-2841. SchumanJ,ChenY,PoddA,YuM,LiuH,WenR,ChenZJ,andWangD.AcriticalroleofTAK1inBcelldevelopmentandactivation.Blood2009;113:4566-4574. FuG,ChenY,YuM,PoddA,SchumanJ,HeY,DiL,YassaiM,HaribhaiD,NorthPE,GorskiJ,WilliamsCB,WangD,andWenR.PhospholipaseCg1isessentialforT-celldevelopment,activationandtolerance.J.Exp.Med.2010;207:309-318. MuellerH,StadtmannA,VanAkenH,WangD,LeyK,andZarbockA.TyrosinekinaseBtkregulatesE-selectin-mediatedintegrinactivation&neutrophilrecruitmentbycontrollingphospholipaseC(PLC)g2andPI3Kgpathways.Blood2010;115:3118-3127. Wuerzberger-DavisS,ChenY,YangDT,BatesP,LadellNC,YuM,PoddA,ZengH,WenR,WangD*andMiyamotoS*.NuclearexportoftheNF-BinhibitorIkBisrequiredforproperBcellandsecondarylymphoidtissueformation.Immunity34:188-200,2011.*equalseniorauthorship ChenY,YuM,DaiX,ZoggM,WenR,WeilerH,andWangD.CriticalroleofGimap5inthesurvivalofmousehematopoieticstemandprogenitorcells.J.Exp.Med.208:923-935,2011. GorjestaniS,YuM,TangB,ZhangD,WangD,andLinX.PhospholipaseCγ2(PLCγ2)IsKeyComponentinDectin-2SignalingPathway,MediatingAnti-fungalInnateImmuneResponsesJ.Biol.Chem.286:43651-43659,2011. NurievaRI,PoddA,ChenY,AlekseevAM,YuM,QiX,HuangH,WenR,WangJ,LiHS,WatowichSS,QiH,DongC,andWangD.STAT5proteinnegativelyregulatesTfollicularhelpercellgenerationandfunction.J.Biol.Chem.287:11234-11239,2012. MalherbeLPandWangD.TyrosinekinasesenAblingadaptormoleculesforchemokine-inducedRap1activationinTcells.ScienceSignal5:pe33,2012. FuG,ChenY,WangD,andWenR.ImportantroleofphospholipaseC2inT-cellreceptorsignaltransductionandT-cellpositiveselection.J.Immunol.189:2326-2332,2012. YuM,ChenY,HeY,PoddA,FuG,WrightJA,KleimanE,KhanWN,WenR,andWangD.CriticalroleofBcelllymphoma10inBAFF-regulatedNF-BactivationandsurvivalofanergicBcells.J.Immunol.189:5185-5193,2012. ZhengY,YuM,PoddA,YuanL,NewmanDK,WenR,ArepallyG,andWangD.CriticalroleformousemarginalzoneBcellsinPF4/heparinantibodyproduction.Blood121:3484-3492,2013. YangXO,ZhangH,KimBS,NiuX,PengJ,ChenY,KerkettaR,LeeYH,ChangSH,CorryDB,WangD,etal.ThesignalingsuppressorCIScontrolsproallergicTcelldevelopmentandallergicairwayinflammation.NatureImmunology14:732-740,2013. QiX,HongJ,ChavesL,ZhuangY,ChenY,WangD,ChabonJ,GrahamB,OhmoriK,LiY,andHuangH.AntagonisticregulationbyC/EBPandMITFspecifiesbasophilandmastcellfates.Immunity39:97-110;2013. ZhengY,WangAW,YuM,PadmanabhanA,TourdotBE,NewmanDK,WhiteGC,AsterAH,WenR,andWangD.Bcelltoleranceregulatesproductionofantibodiescausingheparin-inducedthrombocytopenia.Blood123:931-934;2014. PadmanabhanA,JonesCG,DanielW.BougieDW,CurtisBR,McFarlandJG,WangDandAsterRH.Heparin-independentbindingofHITantibodiestoplatelets:ImplicationsforHITpathogenesis.Blood125:155-161;2015. YongweiZheng,YuM,PadmanabhanA,AsterRH,YuanL,WenR,andWangD.CriticalroleofTcellsinPF4/heparinantibodyproduction.Blood125:1826-1829;2015. YanX.,YanMF,GuoYH,SinghG,ChenY,YuM,WangD,HilleryCAandChanAM.R-RasregulatesmurineTcellmigrationandintercellularadhesionmolecule-1binding.PLoSOne(Inpress). XinG,LainezB,WeinsteinJ,DaiZ,ChenY,EspluguesE,WenR,WangD,CraftJ,andCuiW.AcriticalroleofIL-21inducedBATFinsustainingCD8Tcellmediatedchronicviralcontrol.CellReport(Inpress). ChenY,ZhengY,YouX,YuM,FuG,SuX,ZhouF,ZhuW,WuZ,ZhangJ,WenR,andWangD.KrasiscriticalforBcelllymphopoiesis.J.Immunol.(InPress).

学术兼职

2003-2004美国威斯康星州血液研究所免疫学教职招聘委员会委员 2006-2010美国威斯康星州医学院研究生学习委员会委员 2011-2012美国威斯康星州血液研究所免疫学教职招聘委员会共同主席 2014-现在美国威斯康星州血液研究所干细胞学教职招聘委员会主席 2011-2015基金评审正式委员,分子和细胞血液学研究部,美国国家卫生研究院 2012-现在副主编，JournalofImmunology