个人简介
北京大学化学系学士(1990-1995),美国爱荷华大学分析化学博士(1995-2001),美国艾姆斯国家实验室博士后(2002-2005),2005年6月回国,现任湖南大学化学化工学院教授、博士生导师。长期从事光谱学、显微镜学、纳米技术、单细胞和单分子检测技术研究。近年来的工作主要集中在非荧光单分子成像:通过优化传统暗场显微成像技术的光源、光路和检测器,发展高灵敏度、高时间和空间分辨的新型暗场成像方法,建立一系列以金纳米颗粒为探针的非荧光标记单分子光谱技术,在单分子水平上实时原位考察功能化纳米金与生物大分子及活体细胞的作用过程与机制。以通讯作者发表论文30余篇,其中包括Nat Commun (1 篇 )、J Am Chem Soc (2 篇)、Angew Chem (1 篇)、Anal Chem (10 篇)。曾主持国家自然科学基金青年基金、面上项目、重大研究计划培育项目、科学仪器基础研究专项各一项,并作为骨干参与国家自然科学基金委创新研究群体项目。2007年入选国家“新世纪优秀人才支持计划”,2012年获湖南省自然科学杰出青年基金资助,2014年获国家杰出青年科学基金资助。
近期论文
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Peng, Y.; Xiong, B.; Peng L.; Li, H.; He, Y.*; Yeung, E. S., Recent Advances in Optical Imaging with Anisotropic Plasmonic Nanoparticles. Anal. Chem. 2014, Article ASAP, DOI: 10.1021/ac504061p.
Xu, D.; He, Y.*; Yeung, E. S., Direct Observation of the Orientation Dynamics of Single Protein-Coated Nanoparticles at Liquid/Solid Interfaces. Angew. Chem. Int. Ed. 2014, 53 (27), 6951-6955.
Hao, J.; Xiong, B.; Cheng, X.; He, Y.*; Yeung, E. S., High-Throughput Sulfide Sensing with Colorimetric Analysis of Single Au–Ag Core–Shell Nanoparticles. Anal. Chem. 2014, 86 (10), 4663-4667.
Xu, D.; He, Y.*; Yeung, E. S., Direct Imaging of Transmembrane Dynamics of Single Nanoparticles with Darkfield Microscopy: Improved Orientation Tracking at Cell Sidewall. Anal. Chem. 2014, 86 (7), 3397-3404.
Cheng, X.; Dai, D.; Xu, D.; He, Y.*; Yeung, E. S., Subdiffraction-Limited Plasmonic Imaging with Anisotropic Metal Nanoparticles. Anal. Chem. 2014, 86 (5), 2303-2307.
Xiong, B.; Zhou, R.; Hao, J.; Jia, Y.; He, Y.*; Yeung, E. S., Highly sensitive sulphide mapping in live cells by kinetic spectral analysis of single Au-Ag core-shell nanoparticles. Nat. Commun. 2013, 4:1708.
Zhou, R.; Zhou, H.; Xiong, B.; He, Y.*; Yeung, E. S., Pericellular Matrix Enhances Retention and Cellular Uptake of Nanoparticles. J. Am. Chem. Soc. 2012, 134 (32), 13404-13409.
Xiao, L.; Wei, L.; Cheng, X.; He, Y.*; Yeung, E. S., Noise-Free Dual-Wavelength Difference Imaging of Plasmonic Resonant Nanoparticles in Living Cells. Anal. Chem. 2011, 83 (19), 7340-7347.
Xiao, L.; Qiao, Y.; He, Y.*; Yeung, E. S., Imaging Translational and Rotational Diffusion of Single Anisotropic Nanoparticles with Planar Illumination Microscopy. J. Am. Chem. Soc. 2011, 133 (27), 10638-10645.
Cheng, J.; Liu, Y.; Cheng, X.; He, Y.*; Yeung, E. S., Real Time Observation of Chemical Reactions of Individual Metal Nanoparticles with High-Throughput Single Molecule Spectral Microscopy. Anal. Chem. 2010, 82 (20), 8744-8749.