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表面增强拉曼光谱定量分析技术,多相体系原位光谱分析技术, 化学计量学 研究内容主要包括:表面增强拉曼光谱定量分析基础理论与应用、复杂多相化学与生物体系的原位实时光谱定量分析技术,化学计量学等。

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Chen, Y.; Chen, Z.P.*; Yang J.; Jin, J.W.; Zhang, J.; Yu, R.Q. Quantitative fluorescence spectroscopy in turbid media: a practical solution to the problem of scattering and absorption, Anal. Chem., 85 (2013), 2015–2020 Chen, Z.P*; Li, L.M.; Jin, J.W.; Nordon, A.; Littlejohn, D.; Yang, J.; Zhang, J.; Yu, R.Q. Quantitative analysis of powder mixtures by Raman spectrometry: the influence of particle size and its correction, Anal. Chem., 84 (2012), 4088–4094 Jin, J.W.; Chen, Z.P.*; Li, L.M.; Steponavicius, R.; Thennadil, S.N.; Yang, J.; Yu, R.Q. Quantitative Spectroscopic Analysis of Heterogeneous Mixtures: The correction of multiplicative effects caused by variations in physical properties of samples, Anal. Chem., 84 (2012), 320–326 Chen Z.P.*; Zhong L.J.; Nordon A.; Littlejohn D.; Holden M.; Fazenda M.; Harvey L.; McNeil B.; O’Kennedy R.; Calibration of multiplexing fibre-optic spectroscopy, Anal. Chem. 83 (2011) 2655-2659 Chen Z.P.*; Li L.M.; Yu R.Q.; Littlejohn D.; Nordon A.; Morris J.; Dann A.S.; Jeffkins P.A.; Richardson M.D.; Stimpson S.L.; Systematic prediction error correction: a novel strategy for maintaining the predictive abilities of multivariate calibration models, The Analyst, 136 (2011) 98-106 Chen Z.P.; Lovett D.; Morris J.; Process analytical technologies and real time process control a review of some spectroscopic issues and challenges, Journal of Process Control, 21(2011), 1467– 1482 Du W.; Chen Z.P.*; Zhong L.J.; Wang S.X.; Yu R.Q.; Nordon A.; Littlejohn D.; Holden M.; Maintaining the predictive abilities of multivariate calibration models by spectral space transformation, Anal. Chim. Acta. 690 (2011) 64-70 Chen, Z.P.*; Morris, J. et al., On-line monitoring of batch cooling crystallisation of organic compounds using ATR-FTIR spectroscopy coupled with an advanced chemometric calibration method, Chemometrics and Intelligent Laboratory Systems, 96 (2009) 49-58. Chen, Z.P.; Morris, J. Process analytical technology and compensating for nonlinear effects in process spectroscopic data for improved process monitoring and control, Biotechnology Journal, 4 (2009) 610-619. Borissova, A., Khan, S., Mahmud, T., Roberts, K.J., Andrews, J., Dallin, P., Chen, Z.P., Morris, J. In situ measurement of solution concentration during the batch cooling crystallization of L-glutamic acid using ATR-FTIR spectroscopy coupled with chemometrics, Crystal Growth and Design, 9 (2009) 692-706. Chen, Z.P.*; Morris, J.; Fevotte, G. et al., Advanced calibration strategy for in-situ quantitative monitoring of phase transition processes in suspensions using FT-Raman spectroscopy, Anal. Chem. 80 (2008) 6658-6665. Chen, Z.P.; Morris, J., Improving the linearity of spectroscopic data subjected to fluctuations in external variables by the extended loading space standardization, The Analyst, 133 (2008) 914-922. Chen, Z.P.; Lovett, D.; Morris, J. Process analytical technologies (PAT)-the impact for process systems engineering, Computer Aided Chemical Engineering, 25 (2008) 967-972. Dharmayat, S.; Hammond, R.B.; Lai, X.; Ma C.; Purba, E.; Roberts, K.J.; Chen, Z.P.; Martin, E.; Morris, J.; Bytheway, R. An examination of the kinetics of the solution-mediated polymorphic phase transformation between α- and β-forms of L-glutamic acid as determined using online powder X-ray Diffraction, Crystal Growth and Design, 8 (2008) 2205-2216. Morris, J.; Chen, Z.P. From data to knowledge through smart process analytical technologies (PAT) and process systems engineering, European pharmaceutical review, 6 (2008) 14. Chen, Z.P.; Morris, J.; Martin, E., Extracting chemical information from spectral data with multiplicative light scattering effects by optical path-length estimation and correction, Anal. Chem., 78 (2006) 7674-7681. 梁逸曾,吴海龙,沈国励,蒋健晖,陈增萍,梁晟,俞汝勤, 分析化学计量学的若干新进展,中国科学B辑:化学, 36 (2006) 93-100. Chen, Z.P.; Morris, J.; Martin, E., Correction of temperature-induced spectral variations by loading space standardization, Anal. Chem. 77 (2005) 1376-1384. Chen, Z.P.; Morris, J.; Martin, E.; Hammond, R.B.; Lai, X.J.; Ma, C.Y.; Purba, E.; Roberts, K.J.; Bytheway, R., Enhancing the signal-to-noise ratio of X-ray diffraction profiles by smoothed principal component analysis, Anal. Chem. 77 (2005) 6563-6570. Chen, Z.P.; Morris, J.; Martin, E.; Yu, R.Q.; Liang, Y.Z.; Gong, F., Recursive evolving spectral projection for revealing the concentration windows of overlapping peaks in two-way chromatographic experiments, Chemometrics and Intelligent Laboratory Systems, 72 (2004) 9-19.

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