Isaacs, Lyle - University of Maryland - Department of Chemistry & Biochemistry

个人简介

1987 – 1991 B.S. Chemistry, University of Chicago. 1991 – 1992 M.S. Chemistry, University of California, Los Angeles (UCLA). 1992 – 1995 Ph.D. Organic Chemistry, Swiss Federal Institute of Technology (ETH Zurich) Research with Prof. François Diederich. 1995 – 1998 Postdoc Supramolecular Chemistry, Harvard University, NIH postdoctoral fellow with Prof. George M. Whitesides.

研究领域

The Isaacs group is interested in supramolecular and synthetic chemistry with an emphasis on molecular container molecules known as cucurbit[n]urils (CB[n]). Molecular containers – most commonly cyclodextrins – have enormous everyday applications including scent release and odor control (e.g. Febreeze) in consumer products and foodstuffs. We believe that CB[n] containers will supplant the cyclodextrins in a variety of practical and academic applications with all the attendant societal impact.

近期论文

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Zhang, M.; Cao, L.; Isaacs, L. Cucurbit[6]uril-cucurbit[7]uril heterodimer promotes controlled self-assembly of supramolecular networks and supramolecular micelles by self-sorting of amphiphilic guests. Chem. Comm. 2014, 50, 14756-14759. Siltz, L. A. F.; Viktorova, E. G.; Zhang, B.; Kouiavskaia, D.; Dragunsky, E.; Chumakov, K.; Isaacs, L.; Belov, G. A. New small-molecule inhibitors effectively blocking picornavirus replication. J. Virol. 2014, 88, 11091-11107. Oun, R.; Floriano, R. S.; Isaacs, L.; Rowan, E. G.; Wheate, N. J. The ex vivo neurotoxic, myotoxic and cardiotoxic activity of cucurbituril-based macrocyclic drug delivery vehicles. Toxicol. Res. 2014, 3, 447-455. Robinson, E. L.; Zavalij, P. Y.; Isaacs, L. Synthesis of a disulfonated derivative of cucurbit[7]uril and investigations of its ability to solubilise insoluble drugs. Supramol. Chem. Ahead of print. Huang, F.; Isaacs, L. Guest Editorial: Responsive Host-Guest Systems. Acc. Chem. Res. 2014, 47, 1923-1924. Isaacs, L. Stimuli Responsive Systems Constructed Using Cucurbit[n]uril-Type Molecular Containers. Acc. Chem. Res. 2014, 47, 2052-2062. Pearson, W. H.; Lin, S.; Isaacs, L. D. 2,5-Dioxopyrrolidin-1-yl 2-methylprop-2-enoate. Acta Crystallogr., Sect. E. 2014, E70, O446. Zhang, B.; Zavalij, P.; Isaacs, L. Acyclic CB[n]-type molecular containers: effect of solubilizing group on their function as solubilizing excipients. Org. Biomol. Chem., 2014, 12, 2413-2422. Sekutor, M.; Molcanov, K.; Cao, L.; Isaacs, L.; Glaser, R.; Mlinaric-Majerski, K. Design, Synthesis, and X-ray Structural Analyses of Diamantane Diammonium Salts: Guests for Cucurbit[n]uril (CB[n]) Hosts. Eur. J. Org. Chem., 2014, 2014, 2533–2542. Cao, L.; Sekutor, M.; Zavalij, P.; Mlinaric-Majerski, K.; Glaser, R.; Isaacs, L. Cucurbit[7]uril.Guest Pair with an Attomolar Dissociation Constant. Angew. Chem. Int. Ed., 2014, 53, 988-993. Minami, T.; Esipenko, N.; Zhang, B.; Isaacs, L.; Anzenbacher, P. "Turn-on" fluorescent sensor array for basic amino acids in water. Chem. Commun., 2014, 50, 61-63. Cao, L.; Isaacs, L. Absolute and relative binding affinity of cucurbit[7]uril towards a series of cationic guests. Supramol. Chem., 2014, 26, 251-258. Wittenberg, J.; Isaacs, L. Cucurbit[6]uril dimer induces supramolecular polymerization of a cationic polyethylene glycol derivative. Supramol. Chem., 2014, 26, 157-167. Cao, L.; Hettiarachchi, G.; Briken, V.; Isaacs, L. Cucurbit[7]uril Containers for Targeted Delivery of Oxaliplatin to Cancer Cells. Angew. Chem. Int. Ed., 2013, 52, 12033–12037.