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Phyllanthoside-Phyllanthostatin synthetic studies. 6. An augmented spiroketalization tactic for the total synthesis of phyllanthocin
Tetrahedron Letters ( IF 1.5 ) Pub Date : 1989 , DOI: 10.1016/s0040-4039(00)70688-5 Amos B. Smith , James R. Empfield , Henry A. Vaccaro
Tetrahedron Letters ( IF 1.5 ) Pub Date : 1989 , DOI: 10.1016/s0040-4039(00)70688-5 Amos B. Smith , James R. Empfield , Henry A. Vaccaro
An enhanced spiroketalization maneuver permitting equilibration at both the C(8) and C(11) centers of spiroketals 17a,b leads to a more concise and efficient synthesis of phyllanthocin (i.e., 21 steps, 5.6% overall yield).
中文翻译:
菊蓝苷-Phyllanthostatin合成研究。6.全合成phyllanthocin的增强spiroketalization策略
增强的螺环缩合策略允许在螺环素17a,b的C(8)和C(11)中心均达到平衡,从而导致精索霉素的合成更加简洁有效(即21步,总收率5.6%)。
更新日期:2017-01-31
中文翻译:
菊蓝苷-Phyllanthostatin合成研究。6.全合成phyllanthocin的增强spiroketalization策略
增强的螺环缩合策略允许在螺环素17a,b的C(8)和C(11)中心均达到平衡,从而导致精索霉素的合成更加简洁有效(即21步,总收率5.6%)。