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Modular Metal-Organic Polyhedra Superassembly: From Molecular-Level Design to Targeted Drug Delivery.
Advanced Materials ( IF 27.4 ) Pub Date : 2019-01-31 , DOI: 10.1002/adma.201806774 Wei Zhu 1 , Jimin Guo 1 , Yi Ju 2 , Rita E Serda 3 , Jonas G Croissant 1 , Jin Shang 4 , Eric Coker 5 , Jacob Ongudi Agola 1 , Qi-Zhi Zhong 2 , Yuan Ping 6 , Frank Caruso 2 , C Jeffrey Brinker 1
Advanced Materials ( IF 27.4 ) Pub Date : 2019-01-31 , DOI: 10.1002/adma.201806774 Wei Zhu 1 , Jimin Guo 1 , Yi Ju 2 , Rita E Serda 3 , Jonas G Croissant 1 , Jin Shang 4 , Eric Coker 5 , Jacob Ongudi Agola 1 , Qi-Zhi Zhong 2 , Yuan Ping 6 , Frank Caruso 2 , C Jeffrey Brinker 1
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Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superassembly of nanosized metal–organic polyhedra (MOP) and their biomimetic coatings of lipid bilayers are described to synergistically combine the advantages of micelles and supramolecular coordination cages for targeted drug delivery. The superassembly technique affords unique hydrophobic features that endow individual MOP to act as nanobuilding blocks and enable their superassembly into larger and well‐defined nanocarriers with homogeneous sizes over a broad range of diameters. Various cargos are controllably loaded into the MOP with high payloads, and the nanocages are then superassembled to form multidrug delivery systems. Additionally, functional nanoparticles are introduced into the superassemblies via a one‐pot process for versatile bioapplications. The MOP superassemblies are surface‐engineered with epidermal growth factor receptors and can be targeted to cancer cells. In vivo studies indicated the assemblies to have a substantial circulation half‐life of 5.6 h and to undergo renal clearance—characteristics needed for nanomedicines.
中文翻译：
模块化的金属有机多面体超级组装：从分子水平设计到靶向药物递送。
靶向药物的交付仍然处于生物医学研究的前沿，但迄今为止仍然是一个挑战。本文中，描述了纳米级金属-有机多面体（MOP）的首次超级组装及其脂质双层的仿生涂层，将胶束和超分子配位笼的优势协同地用于靶向药物递送。超级组装技术具有独特的疏水特性，使单个的MOP可以充当纳米构建基块，并使其能够超级组装成较大且定义明确的纳米载体，并且在较大的直径范围内具有均一的大小。将各种货物以高有效载荷可控地装载到MOP中，然后将纳米笼子进行超级组装以形成多药递送系统。此外，通过一锅法将功能性纳米颗粒引入超级组件，以实现多种生物应用。MOP超级组件采用表皮生长因子受体进行表面工程处理，可以靶向癌细胞。体内研究表明，该组件具有5.6 h的显着循环半衰期，并需要进行肾脏清除-这是纳米药物所需的特征。
更新日期：2019-01-31
中文翻译：
模块化的金属有机多面体超级组装：从分子水平设计到靶向药物递送。
靶向药物的交付仍然处于生物医学研究的前沿，但迄今为止仍然是一个挑战。本文中，描述了纳米级金属-有机多面体（MOP）的首次超级组装及其脂质双层的仿生涂层，将胶束和超分子配位笼的优势协同地用于靶向药物递送。超级组装技术具有独特的疏水特性，使单个的MOP可以充当纳米构建基块，并使其能够超级组装成较大且定义明确的纳米载体，并且在较大的直径范围内具有均一的大小。将各种货物以高有效载荷可控地装载到MOP中，然后将纳米笼子进行超级组装以形成多药递送系统。此外，通过一锅法将功能性纳米颗粒引入超级组件，以实现多种生物应用。MOP超级组件采用表皮生长因子受体进行表面工程处理，可以靶向癌细胞。体内研究表明，该组件具有5.6 h的显着循环半衰期，并需要进行肾脏清除-这是纳米药物所需的特征。
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