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Itaconate: the poster child of metabolic reprogramming in macrophage function.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-05-01 , DOI: 10.1038/s41577-019-0128-5 Luke A J O'Neill 1 , Maxim N Artyomov 2
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-05-01 , DOI: 10.1038/s41577-019-0128-5 Luke A J O'Neill 1 , Maxim N Artyomov 2
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Itaconate is one of the best examples of the consequences of metabolic reprogramming during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle during inflammatory macrophage activation. The main reason macrophages exhibit this response currently appears to be for an anti-inflammatory effect, with itaconate connecting cell metabolism, oxidative and electrophilic stress responses and immune responses. A role for itaconate in the regulation of type I interferons during viral infection has also been described, as well as in M2 macrophage function under defined circumstances. Finally, macrophage-specific itaconate production has also been shown to have a pro-tumour effect. All of these studies point towards itaconate being a critical immunometabolite that could have far-reaching consequences for immunity, host defence and tumorigenesis.
中文翻译：
衣康酸酯：巨噬细胞功能中代谢重编程的后代。
衣康酸酯是免疫过程中代谢重编程后果的最好例证之一。它是通过在炎性巨噬细胞活化过程中将乌头酸从三羧酸循环中转移出来而制成的。巨噬细胞目前表现出这种反应的主要原因似乎是抗炎作用，其衣康酸连接细胞的新陈代谢，氧化和亲电应激反应以及免疫反应。还描述了衣康酸酯在病毒感染期间在I型干扰素调节中的作用，以及在特定情况下在M2巨噬细胞功能中的作用。最后，巨噬细胞特异性衣康酸酯的产生也已被证明具有促肿瘤作用。所有这些研究都指出衣康酸酯是一种重要的免疫代谢物，可能会对免疫产生深远的影响，
更新日期：2019-05-16
中文翻译：
衣康酸酯：巨噬细胞功能中代谢重编程的后代。
衣康酸酯是免疫过程中代谢重编程后果的最好例证之一。它是通过在炎性巨噬细胞活化过程中将乌头酸从三羧酸循环中转移出来而制成的。巨噬细胞目前表现出这种反应的主要原因似乎是抗炎作用，其衣康酸连接细胞的新陈代谢，氧化和亲电应激反应以及免疫反应。还描述了衣康酸酯在病毒感染期间在I型干扰素调节中的作用，以及在特定情况下在M2巨噬细胞功能中的作用。最后，巨噬细胞特异性衣康酸酯的产生也已被证明具有促肿瘤作用。所有这些研究都指出衣康酸酯是一种重要的免疫代谢物，可能会对免疫产生深远的影响，
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