Weinreb Amide as Secondary Station for the Dibenzo‐24‐crown‐8 in a Molecular Shuttle,European Journal of Organic Chemistry

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Weinreb Amide as Secondary Station for the Dibenzo‐24‐crown‐8 in a Molecular Shuttle
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2019-02-11 , DOI: 10.1002/ejoc.201900046
Maxime Gauthier ₁ , Frédéric Coutrot ₁

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A [2]rotaxane molecular shuttle containing an ammonium and a Weinreb amide molecular station for dibenzo‐24‐crown‐8 is reported. The Weinreb amide proved to be an efficient secondary molecular station upon carbamoylation of the ammonium. Although the amide was easily cleaved by a Grignard reagent in the non‐interlocked analogue, no cleavage was possible in the rotaxane species, due to the protective shield of the surrounding crown ether.

中文翻译：

Weinreb酰胺作为分子穿梭中Dibenzo-24-crown-8的二级工作站

据报道有一个[2]轮烷分子穿梭分子，其中含有一个铵和一个Weinreb酰胺分子站，用于二苯并24-冠-8。经证明，将氨甲酰化后，Weinreb酰胺是有效的二级分子站。尽管在非互锁类似物中酰胺很容易被格氏试剂裂解，但由于周围冠醚的保护性屏蔽，轮状烷物种无法裂解。

更新日期：2019-02-11

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