Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV⁺) and somatostatin (SST⁺) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST⁺ cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.

中文翻译：

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Mafb和c-Maf在皮质神经元的命运和功能中具有产前补偿和产后拮抗作用。

Mafb和c-Maf转录因子（TF）的表达在内侧神经节隆起（MGE）谱系中丰富，始于次级继发祖细胞，并持续进入成熟的小白蛋白（PV ⁺）和生长抑素（SST ⁺）中间神经元。但是，Maf TF在MGE开发中的功能仍有待阐明。在此，Mafb和c-Maf有条件地在MGE及其谱系中被单独或一起删除。对Maf突变小鼠的分析表明，Mafb和c-Maf在次级MGE祖细胞中具有多余的功能，它们在其中抑制SST ⁺的生成。皮质和海马interneurons。相比之下，Mafb和c-Maf在出生后皮质中间神经元（CIN）形态成熟，突触形成和皮质回路整合中具有独特的作用。因此，Mafb和c-Maf在CIN开发的不同步骤中具有冗余且相对的功能。