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Ingestible hydrogel device.
Nature Communications ( IF 14.7 ) Pub Date : 2019-01-30 , DOI: 10.1038/s41467-019-08355-2 Xinyue Liu 1 , Christoph Steiger 2, 3 , Shaoting Lin 1 , German Alberto Parada 1, 4 , Ji Liu 1 , Hon Fai Chan 1, 5, 6 , Hyunwoo Yuk 1 , Nhi V Phan 2 , Joy Collins 2 , Siddartha Tamang 2 , Giovanni Traverso 1, 2, 3, 4 , Xuanhe Zhao 1, 7
Nature Communications ( IF 14.7 ) Pub Date : 2019-01-30 , DOI: 10.1038/s41467-019-08355-2 Xinyue Liu 1 , Christoph Steiger 2, 3 , Shaoting Lin 1 , German Alberto Parada 1, 4 , Ji Liu 1 , Hon Fai Chan 1, 5, 6 , Hyunwoo Yuk 1 , Nhi V Phan 2 , Joy Collins 2 , Siddartha Tamang 2 , Giovanni Traverso 1, 2, 3, 4 , Xuanhe Zhao 1, 7
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Devices that interact with living organisms are typically made of metals, silicon, ceramics, and plastics. Implantation of such devices for long-term monitoring or treatment generally requires invasive procedures. Hydrogels offer new opportunities for human-machine interactions due to their superior mechanical compliance and biocompatibility. Additionally, oral administration, coupled with gastric residency, serves as a non-invasive alternative to implantation. Achieving gastric residency with hydrogels requires the hydrogels to swell very rapidly and to withstand gastric mechanical forces over time. However, high swelling ratio, high swelling speed, and long-term robustness do not coexist in existing hydrogels. Here, we introduce a hydrogel device that can be ingested as a standard-sized pill, swell rapidly into a large soft sphere, and maintain robustness under repeated mechanical loads in the stomach for up to one month. Large animal tests support the exceptional performance of the ingestible hydrogel device for long-term gastric retention and physiological monitoring.
中文翻译：
可摄入的水凝胶装置。
与生物体相互作用的设备通常由金属、硅、陶瓷和塑料制成。植入此类装置进行长期监测或治疗通常需要侵入性操作。水凝胶由于其卓越的机械顺应性和生物相容性，为人机交互提供了新的机会。此外，口服给药与胃驻留相结合，可以作为植入的非侵入性替代方案。使用水凝胶实现胃驻留需要水凝胶非常快速地膨胀并随着时间的推移承受胃机械力。然而，现有水凝胶并不同时存在高溶胀比、高溶胀速度和长期稳定性。在这里，我们介绍了一种水凝胶装置，它可以作为标准尺寸的药丸摄入，迅速膨胀成一个大的软球体，并在胃内重复机械负荷下保持长达一个月的坚固性。大型动物测试支持可摄入水凝胶装置在长期胃滞留和生理监测方面的卓越性能。
更新日期：2019-01-30
中文翻译：
可摄入的水凝胶装置。
与生物体相互作用的设备通常由金属、硅、陶瓷和塑料制成。植入此类装置进行长期监测或治疗通常需要侵入性操作。水凝胶由于其卓越的机械顺应性和生物相容性，为人机交互提供了新的机会。此外，口服给药与胃驻留相结合，可以作为植入的非侵入性替代方案。使用水凝胶实现胃驻留需要水凝胶非常快速地膨胀并随着时间的推移承受胃机械力。然而，现有水凝胶并不同时存在高溶胀比、高溶胀速度和长期稳定性。在这里，我们介绍了一种水凝胶装置，它可以作为标准尺寸的药丸摄入，迅速膨胀成一个大的软球体，并在胃内重复机械负荷下保持长达一个月的坚固性。大型动物测试支持可摄入水凝胶装置在长期胃滞留和生理监测方面的卓越性能。
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