Enantioselective Radical Hydroacylation of Enals with α-Ketoacids Enabled by Photoredox/Amine Cocatalysis,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Enantioselective Radical Hydroacylation of Enals with α-Ketoacids Enabled by Photoredox/Amine Cocatalysis
Organic Letters ( IF 4.9 ) Pub Date : 2019-01-29 00:00:00 , DOI: 10.1021/acs.orglett.8b03840
Jia-Jia Zhao ₁ , Hong-Hao Zhang ₁ , Xu Shen ₁ , Shouyun Yu ₁

Affiliation

A photoredox/amine-cocatalyzed enantioselective radical hydroacylation of enals with α-ketoacids is described. Acyl radicals generated from α-ketoacids act as the acylation reagent with the iminium ions. This strategy provides an efficient way to access synthetically challenging 1,4-dicarbonyl compounds in an enantioselective manner. The reactions of various enals with α-ketoacids show the generality and limitations of this method.

中文翻译：

光氧化还原/胺共催化实现的α-酮酸对映体对映体的选择性自由基加氢酰化

描述了用α-酮酸对烯进行光氧化还原/胺催化的对映选择性自由基加氢酰化。由α-酮酸产生的酰基自由基与亚胺离子一起作为酰化剂。该策略提供了一种以对映选择性的方式访问合成中具有挑战性的1,4-二羰基化合物的有效方法。各种烯类与α-酮酸的反应表明了该方法的普遍性和局限性。

更新日期：2019-01-29

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南