Two novel core-shell fibers which could self-assemble liposome were fabricated based on bioadhesive polymer carboxymethyl chitosan (CMCS) and Sodium carboxymethyl cellulose (CMC-Na), separately. The shell layers were CMCS/PVA and CMC-Na/PVA, respectively, and the core layer was mixture of PVP, Phospholipids (PC) and Carvedilol (Car). The diameter distribution and core/shell structure were examined by SEM and CLSM. FTIR and XRD were also used to characterize the fiber. Self-assembled liposome was observed by TEM, and other parameters like drug encapsulation efficiency was also determined. In vitro adhesive force was conducted to evaluate bioadhesive property of fibers. Dissolution test demonstrated Car was almost completely released within 2 h and presented linear release. The permeation studies across porcine TR146 cell culture and buccal mucosa were carried out, indicating self-assembled liposome and bioadhesive polymer both promoted drug penetration. MTT test showed TR146 cells were safe after incubation with fibers' extraction medium under the concentration of 10 mg/mL. In summary, this design based on self-assembled liposome and core/shell fiber using water-soluble bioadhesive polymer was desirable for Car buccal absorption.

分别基于生物粘附性聚合物羧甲基壳聚糖（CMCS）和羧甲基纤维素钠（CMC-Na）制备了两种可以自组装脂质体的新型核壳纤维。壳层分别是CMCS / PVA和CMC-Na / PVA，核心层是PVP，磷脂（PC）和卡维地洛（Car）的混合物。通过SEM和CLSM检查直径分布和核/壳结构。FTIR和XRD也用于表征光纤。通过TEM观察自组装脂质体，并且还确定了诸如药物包封效率的其他参数。进行体外粘合力以评估纤维的生物粘合性能。溶出度测试表明Car在2小时内几乎完全释放，并呈线性释放。进行了跨猪TR146细胞培养和颊粘膜的渗透研究，表明自组装脂质体和生物粘附性聚合物均促进了药物渗透。MTT测试表明，在浓度为10 mg / mL的纤维提取液中孵育后，TR146细胞是安全的。总而言之，这种基于使用水溶性生物粘附性聚合物的自组装脂质体和核/壳纤维的设计对于汽车颊部吸收是合乎需要的。