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The dynamic nature of senescence in cancer.
Nature Cell Biology ( IF 17.3 ) Pub Date : 2019-01-02 , DOI: 10.1038/s41556-018-0249-2 Soyoung Lee 1, 2, 3 , Clemens A Schmitt 1, 2, 3
Nature Cell Biology ( IF 17.3 ) Pub Date : 2019-01-02 , DOI: 10.1038/s41556-018-0249-2 Soyoung Lee 1, 2, 3 , Clemens A Schmitt 1, 2, 3
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Cellular senescence is implicated in physiological and pathological processes spanning development, wound healing, age-related decline in organ functions and cancer. Here, we discuss cell-autonomous and non-cell-autonomous properties of senescence in the context of tumour formation and anticancer therapy, and characterize these properties, such as reprogramming into stemness, tissue remodelling and immune crosstalk, as far more dynamic than suggested by the common view of senescence as an irreversible, static condition.
中文翻译：
癌症衰老的动态性质。
细胞衰老与生理和病理过程有关，包括发育、伤口愈合、与年龄相关的器官功能衰退和癌症。在这里，我们讨论了在肿瘤形成和抗癌治疗的背景下衰老的细胞自主和非细胞自主特性，并描述了这些特性，例如重编程为干性、组织重塑和免疫串扰，比所建议的更具动态性。人们普遍认为衰老是一种不可逆转的静态状态。
更新日期：2019-01-25
中文翻译：
癌症衰老的动态性质。
细胞衰老与生理和病理过程有关，包括发育、伤口愈合、与年龄相关的器官功能衰退和癌症。在这里，我们讨论了在肿瘤形成和抗癌治疗的背景下衰老的细胞自主和非细胞自主特性，并描述了这些特性，例如重编程为干性、组织重塑和免疫串扰，比所建议的更具动态性。人们普遍认为衰老是一种不可逆转的静态状态。
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